Charles S. Goldsmith's research works | Texas A&M University, Texas (TAMU) and other places

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Correction to: inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness

Article

Full-text available

Jan 2019

Following publication of the original article [1], we have been notified that the tagging of one of the author names was done incorrectly in the XML version of the paper. The online and pdf versions of this paper are not affected by the change. Original and corrected tagging can be seen below. The original article has been corrected.

Fig. 3 VX-745 inhibits p38 MAPK activity in cultured Per2 Luc SCN cells...

Fig. 4 VX-745 shortens the period of clock gene rhythms in cultured...

Abbreviations bHLH: Basic helix-loop-helix; ERK: Extracellular...

Inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness

Article

Full-text available

Jan 2018

Background: The circadian clock is the basis for biological time keeping in eukaryotic organisms. The clock mechanism relies on biochemical signaling pathways to detect environmental stimuli and to regulate the expression of clock-controlled genes throughout the body. MAPK signaling pathways function in both circadian input and output pathways in...

Supplementary Material 1

Data

Jan 2018

Supplementary Material 2

Data

Jan 2018

Diverse Roles for MAPK Signaling in Circadian Clocks

Article

Nov 2013

The mitogen-activated protein kinase (MAPK) family of genes aids cells in sensing both extracellular and intracellular stimuli, and emerging data indicate that MAPKs have fundamental, yet diverse, roles in the circadian biological clock. In the mammalian suprachiasmatic nucleus (SCN), MAPK pathways can function as inputs allowing the endogenous clo...

Figure S2

Data

Nov 2011

Phospho-OS-2 is induced by salt treatment in the ΔLRE1-3-os4 mutant. Liquid cultures of the indicated strains were grown in 1× Vogels salts, 0.5% arginine, 2% glucose, pH 6.0, in LL for 24 h at 30°C and then transferred to DD at 25°C. After 24 h of growth in DD, the cultures were treated with 4% NaCl for the indicated times and Western blots for ph...

Figure S4

Data

Nov 2011

os-1, os-5, and rrg-1 mRNA do not accumulate with a circadian rhythm. RNA was prepared from tissue grown in the dark (DD) for the indicated times, and transcripts were detected on northern blots using [α-32P]-UTP labeled anti-sense RNA probes for os-1, os-5, and rrg-1. Densitometirc analysis of the northern blots are plotted as the level of mRNA ov...

Figure 1. WC-2 binds to the os-4 promoter and binding is necessary for...

Figure 3. The WCC binds rhythmically to the os-4 promoter. Plot of...

Figure 4. Deletion of the WCC binding site on the os-4 promoter...

Figure 5. The hpt-1 gene is expressed with a circadian rhythm. (A)...

Figure 8. Model of circadian regulation of the OS MAPK pathway. See the...

Direct Transcriptional Control of a p38 MAPK Pathway by the Circadian Clock in Neurospora crassa

Article

Full-text available

Nov 2011

MAPK signal transduction pathways are important regulators of stress responses, cellular growth, and differentiation. In Neurospora, the circadian clock controls rhythms in phosphorylation of the p38-like MAPK (OS-2); however, the mechanism for this regulation is not known. We show that the WCC, a transcription factor and clock component, binds to...

Figure S3

Data

Nov 2011

os-4 mRNA is induced by salt treatment in the ΔLRE1-3-os4 mutant. Cultures were grown as described in Supplemental Figure S2 and os-4 mRNA detected by northern blot. (TIF)

Figure S1

Data

Nov 2011

os-4 mRNA rhythms persist in rrg-1 mutants. Northern blot assay detecting os-4 mRNA. Cells from mutant strains were harvested at the indicated times in the dark (DD). The RRG-1 deletion strain KB1052 [10], obtained from Dr. Katherine Borkovich, and the rrg-1 null mutant strain (rrg-1COP1-4) [2] have been previously described. (TIF)

Defining a mechanism of circadian output in Neurospora crassa : temporal regulation of a MAP kinase pathway

Article

Apr 2011

In the filamentous fungus Neuropora crassa, the Osmotically Sensitive (OS) signal transduction pathway is rhythmically activated and functions as an output pathway from the circadian clock. This conserved fungal pathway is composed of a sensory phosphorelay coupled to a mitogen activated protein kinase (MAPK) cascade. Our goal is to define the mech...

Circadian rhythmicity mediated by temporal regulation of the activity of p38 MAPK

Article

Full-text available

Dec 2007

Circadian clocks are composed of central oscillators, input pathways that transduce external information to the oscillators, and output pathways that allow the oscillators to temporally regulate cellular processes. Little is known about the output pathways. In this study, we show that the Neurospora crassa osmosensing MAPK pathway, essential for os...