Changyong Wu's research while affiliated with Xuzhou Medical College and other places
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Publications (6)
Background
Glioblastoma multiforme (GBM) is a devastating disease that lacks effective drugs for targeted therapy. Previously, we found that the third-generation epidermal growth factor receptor (EGFR) inhibitor AZD-9291 persistently blocked the activation of the ERK pathway but had no inhibitory effect on the phosphoinositide 3-kinase (PI3K)/Akt p...
Background
Glioblastoma (GBM) is a brain tumor with the highest level of malignancy and the worst prognosis in the central nervous system. Mitochondrial metabolism plays a vital role in the occurrence and development of cancer, which provides critical substances to support tumor anabolism. Mito-LND is a novel small-molecule inhibitor that can selec...
Glioblastoma multiforme (GBM) is a brain tumor with high mortality and recurrence rate. Radiotherapy and chemotherapy after surgery are the main treatment options available for GBM. However, patients with glioblastoma have a grave prognosis. The major reason is that most GBM patients are resistant to radiotherapy. UBA1 is considered an attractive p...
Glioblastoma multiforme (GBM) is the most aggressive malignant primary brain tumor of the central nervous system. Despite continuous progression in treatment options for GBM like surgery, radiotherapy, and chemotherapy, this disease still has a high rate of recurrence. The endoplasmic reticulum (ER) stress pathway is associated with chemotherapeuti...
Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor for which new therapeutic approaches are urgently required. Unfolded protein response (UPR) plays an important role in the progression of GBM and is a promising target for developing novel therapeutic interventions. We identified ubiquitin-activating enzyme 1 (UBA1) inhibitor TAK-...
Citations
... RAS inhibitors are therefore promising adjuvant agents in the treatment of different types of cancers. A few preclinical studies have shown favorable results for the RAS inhibitor, telmisartan, using different GBM cell lines [73,74]. In a recent study, telmisartan inhibited cell proliferation, migration, and invasion by initiating G0G1 phase cell cycle arrest and apoptosis [75]. ...
... GRP78 can translocate to the nucleus and regulate transcription of the epidermal growth factor receptor (EGFR) [28]. As would be expected as a regulator of EGFR, RAS, and PI3K signaling, knock down or small molecule inhibition of GRP78 enhances tumor cell chemosensitivity [29][30][31][32]. Equally, over-expression of GRP78 stabilizes protein expression, suppresses ER stress signaling and maintains tumor cell viability. ...
... Although comprehensive treatment regimens including surgery, chemotherapy with temozolomide, and radiation therapy are used in the clinic to treat this condition, patient prognosis remains poor. Patients diagnosed with GBM have a mean overall survival of only 12-15 months, and the five-year survival rate is less than 6% [2][3][4]. ...
