Changchun Xie's research while affiliated with University of Cincinnati and other places

Admixed populations result from recent admixture of two or more ancestral populations with divergent allele frequencies. The genome of each admixed individual is a mosaic of haplotypes inherited from the ancestral populations. Despite the substantial work to assess power and sample size requirements for association mapping in genetically homogeneous populations of European ancestry, power and sample size estimation methods for mapping genes in genetically heterogeneous admixed populations such as African Americans are lacking. Admixture mapping is a method that traces the ancestral origin of disease susceptibility genetic loci in the admixed population. We developed AdmixPower, a freely available tool-set based on the open-source R software to perform power and sample size analysis for genetically heterogeneous admixed populations considering continuous or dichotomous outcome with case-only or case-control study design. AdmixPower can be used to compute the sample size required to achieve investigator-specified statistical power under several key parameters including ancestry odds-ratio, genotype risk ratio, parental risk ratio, an underlying genetic risk model, trait type, and admixture model (hybrid-isolation or continuous gene flow model). We demonstrate that differences in the key parameters in the admixed population results in substantial difference in sample size requirement to achieve adequate power in admixture mapping studies. Our tool provides a resource for researchers to develop a strategy to minimize cost and maximize the success of identifying disease-susceptibility loci in an admixed population. R code used in the sample size and power analysis is freely available from https://research.cchmc.org/mershalab/Tools.html.