Chad M Amosson's research while affiliated with Baylor College of Medicine and other places
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Publications (12)
The purpose of this paper was to assess the effect of setup uncertainty on dosimetry of prostate, seminal vesicles, bladder, rectum, and colon in prostate cancer patients treated with Peacock intensity-modulated radiation therapy (IMRT). Ten patients underwent computed tomography (CT) scans using the "prostate box" for external, and an "endorectal...
This study was undertaken to compare prostate and normal tissue dosimetry in prostate cancer patients treated with intensity-modulated radiation therapy (IMRT) and conventional 3-dimensional conformal radiotherapy (3DCRT) using an endorectal balloon for prostate immobilization. Ten prostate cancer patients were studied using both IMRT and conventio...
Intensity modulated radiation therapy (IMRT) is gaining widespread use in the radiation therapy community. Prostate cancer is the ideal target for IMRT due to the growing body of literature supporting dose escalation and normal tissue limitations. The need for dose escalation and the limits of conventional radiation therapy necessitate precise pati...
To evaluate the predictors of xerostomia in the treatment of head-and-neck cancers treated with intensity-modulated radiation therapy (IMRT), using the simultaneous modulated accelerated radiation therapy (SMART) boost technique. Dosimetric parameters of the parotid glands are correlated to subjective salivary gland function.
Between January 1996 a...
The treatment of head and neck cancer has evolved from conventional fields encompassing large volumes of normal tissue to focused treatment aimed at conforming the dose around the target while avoiding normal tissue. Intensity modulated radiation therapy has changed the way radiation oncologists think about head and neck cancer. Using the concepts...
The presence of nodal metastases is the most important prognostic factor in cervical cancer. To adjust our therapy based on the true extent of the patient's disease, we performed an extraperitoneal lymph node dissection (EPLND) in all patients with cervical cancer prior to radiotherapy (RT) or radical hysterectomy.
Thirty-three patients with carcin...
Citations
... However, clinical studies comparing SIB-IMRT and sequential IMRT are scarce. Most clinical results of NPC treated by IMRT use the SIB technique [6,[11][12][13][14][15][16][17][18] and rarely compare with the sequential one. ...
... The toxicity scores obtained for both the control and study arms were in good agreement with historical data from the literature. In the study arm, 53.3% of patients had Grade 3 mucositis compared to 80% and 47.3% in the Butler et al. [9] and Amosson et al. [16] studies, respectively. The higher grades of hoarseness in SMART arm could also be attributed to higher proportion of hypopharyngeal and laryngeal tumours in which cases the glottis must have had received higher dose, thereby leading to increased toxicity. ...
... nicznych zamiast zwiększenia dawki w obszarze guza nowotworowego wprowadzono świadomie w jego części dawkę mniejszą. Jest to zupełnie nowa możliwość wykorzystania techniki IMRT [4,10,23,28,33]. W trz(3ch przypadkach przystępując do planowania rozkładu dawki znane były obszary, w których należało zwiększyć lub zmniejszyć dawkę promieniowania, natomiast pierwszy i ostatni przypadek wymagały zmiany rozkładu dawki już w czasie trwania radioterapii. ...
... Although lymph node (LN) involvement was not included in the FIGO 2009 staging, it has always been a major factor in treatment planning 14 . Patients found to have positive nodes were not considered suitable for surgery regardless of tumour size and other characteristics and were directly referred to chemoradiation 15,16 . In many parts of the world, surgico-pathological assessment of paraaortic nodes is considered necessary before offering extended field radiation to women with locally advanced disease, recognizing the side-effects of this treatment 15,17 . ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/279319504015367-1443606367643_Q64/Joseph-Salama.jpg)
... The future research direction for earlystage NPC is toward improvement of the quality of life and, for example avoiding radiation-induced xerostomia, trismus, and mandible radionecrosis. The knowledge about dose-response for parotid function is steadily improving (17,18). With intensity-modulated radiotherapy, we can lower the dose to the brainstem, spinal cord, parotid, mandible, and temporomandibular joint, thereby avoiding treatment-related complications (19). ...
... However, despite significant improvements in delivery technologies, numerous patients develop recurrence following treatment with curative intent. As prostate cancer progresses, the current therapeutic options for advanced prostate cancer are limited to androgen deprivation and/or the cytotoxic effects of high-dose radiation on the surrounding tissues with the aim to extend the survival time of the patient while maintaining quality of life (14). Therefore, it may be hypothesized that the combination of radiation with BTV to target prostate cells represents an attractive treatment option. ...
... These techniques generate a steep dose fall-off to nearby uninvolved structures and deliver a highly conformal radiation dose to the tumor, while minimizing the dose to normal, healthy tissues [5,6]. The accuracy and effectiveness of radiotherapy requires accurate tumor localization, considering internal organ motion, and setup error [7][8][9][10]. The present study aimed at comparing monitor unit (MU), treatment time variations, volume coverage dissimilarity, second tumor incidence, etc., among treatment plans of 3D-CRT, IMRT, and VMAT for prostate cancer based on literature review. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272460767559705-1441971117749_Q64/Salahuddin-Ahmad-5.jpg)
... This study investigated 22 prostate cancers cases through the lenses of radiobiological parameters such as EUD, NTCP, and TCP that were well established [6,15] to characterize treatment plans. We reported on NTCP values of the bladder, femoral head, and bowel close to 0.0% like that observed by both Vlachaki et al and Luxton et al. [16,17]. The large standard deviation (±113.44 cc) seen in bladder volume in our study, suggests a higher degree of variability for bladder filling. ...
... Taste dysfunction after cancer therapy is common and reported to affect up to 93% of patients receiving chemotherapy [44,45], rebounding to 47% and 48% at 6 months and 1 year after treatment, respectively [39]. Additionally, 100% of those receiving RT to the head and neck experience taste dysfunction and the degree [46] is proportional to the RT dose delivered [47]. Taste dysfunction with RT also rebounds over time. ...
