Cecilio Santander's research while affiliated with Instituto de Investigación Sanitaria La Fe and other places

... Anyway, no guidelines recommend such practice, and this is reflected in the expertise of recruiting sites in EoE CONNECT. The DSS score is not validated for measuring symptoms of EoE in children and adolescents, despite its demonstrated ability to capture changes induced by therapy [19,37,40,41], even in randomized placebo-controlled trials [42]. Adherence to EoE treatment was not systematically assessed, and no efforts were made to determine medication compliance beyond the usual advice in each physician's practice [27]; Therefore, the expected effectiveness of each intervention in a conventional clinical use setting is provided. ...

... These data confirm that PPIs also constitute an effective treatment for reversing the fibrosis associated with EoE, in the short term, in children. This had previously been demonstrated in a large series of adults [38], in whom endoscopic reversal of fibrosis was associated with an increase in esophageal caliber, measured by planimetry with endoFLIP [39] in a subgroup of cases. ...

... The wide access to omics technologies has favored the application of these methodologies in studies trying to determine which patients will respond to PPIs at the point of EoE diagnosis. The first studies evaluated the transcriptome profile, but no differences were found [40,69]; a result that was later confirmed [70,71]. ...

... Palabras clave: malabsorción/intolerancia a fructosa; malabsorción/intolerancia a lactosa; sobrecrecimiento bacteriano intestinal; sobrecrecimiento metanogénico intestinal; test de aliento espirado Introducción El sobrecrecimiento bacteriano intestinal (SCBI) es un problema digestivo funcional producido por un crecimiento excesivo de la microbiota bacteriana en el intestino delgado y se acompaña de síntomas como hinchazón, flatulencia, dolor abdominal y diarrea o estreñimiento [1,2]. Estos síntomas pueden ser debidos a una alteración en la permeabilidad y motilidad intestinal, un mayor grado de inflamación o de activación inmune, una malabsorción de nutrientes o la fermentación de sustratos en el intestino delgado [3]. ...

... Studies have shown that DI improves after treatment with topical steroids, suggesting that EndoFLIP can be used to assess the efficacy of therapy. [76] Histopathology Histopathological evaluation is the gold standard of EoE diagnosis, providing definitive evidence of eosinophilic inflammation within the esophageal mucosa. The presence of eosinophils in the esophageal mucosa is a hallmark feature of EoE, and a comprehensive understanding of the histological changes aids accurate diagnosis and differentiation from other esophageal disorders. ...

... Those patients that achieved histological response (i.e., less than 15 eosinophils per hpf in the biopsy) after PPI treatment were classified as responders, and those who did not (i.e., 15 or more eosinophils per hpf) were considered non-responders. Additionally, clinical data including demographics, symptoms, disease duration (defined from symptoms onset to baseline endoscopy), and atopic background were collected from all patients' clinical records [36]. ...

... The aqueous extract of A. aspera probably effects modulation of multiple molecular signaling networks as shown in a recent study, where it was also found to offer protection against cisplatin-induced nephrotoxicity in a murine model by alleviating oxidative stress, inflammation, and PANoptosis [44]. Since asthma exacerbations are a major cause for asthma morbidity and inhibition of Th2 cytokines (IL-4, IL-5, and IL-13) offers significant protection against them [45], safe therapeutics like AaAq that target eosinophils and their mediators could also be effective against multimorbidities associated with type 2 inflammation [46]. ...