Cati Raluca Stolniceanu's research while affiliated with Universitatea de Medicina si Farmacie Grigore T. Popa Iasi and other places
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Publications (29)
The memory-enhancing activity of Matricaria chamomilla hydroalcoholic extract (MCE) is already being investigated by behavioral and biochemical assays in scopolamine-induced amnesia rat models, while the effects of scopolamine (Sco) on cerebral glucose metabolism are examined as well. Nevertheless, the study of the metabolic profile determined by a...
Oncolytic viruses (OVs) are emerging as potential treatment options for cancer. Natural and genetically engineered viruses exhibit various antitumor mechanisms. OVs act by direct cytolysis, the potentiation of the immune system through antigen release, and the activation of inflammatory responses or indirectly by interference with different types o...
The high energy of α emitters, and the strong linear energy transfer that goes along with it, lead to very efficient cell killing through DNA damage. Moreover, the degree of oxygenation and the cell cycle state have no impact on these effects. Therefore, α radioisotopes can offer a treatment choice to individuals who are not responding to β− or gam...
Brown Adipose Tissue (BAT) is considered beneficial in diabetes and obesity, but it can also have negative effects such as its implication in tumours’ pathogenesis and the development of Cancer-induced Cachexia. Since 18F-FDG PET/CT is a common molecular imaging modality used in cancer assessment, we aim to study the 18F-FDG BAT biodistribution in...
Transthyretin cardiac amyloidosis (ATTR) is a rare cardiac protein deposition disease characterized by progressive thickening of both ventricles, the inter-atrial-ventricular septum and the atrioventricular valves. The gold standard method for diagnosing this rare pathology is endomyocardial biopsy. If this method cannot be used, the alternative is...
Brown adipose tissue (BAT) participates in the regulation of whole-body metabolism by producing a variety of adipokines. This study investigates into the BAT pattern and the clinical aspects of overweight and obese (OOB) vs. non-obese (NO) hyperparathyroidism (HPT) patients with the aim of assessing the impact of BAT and obesity on HPT. Parathyroid...
Colorectal cancer is a major cause of cancer-related death worldwide and is correlated with genetic and epigenetic alterations in the colonic epithelium. Genetic changes play a major role in the pathophysiology of colorectal cancer through the development of gene mutations, but recent research has shown an important role for epigenetic alterations....
Immunotherapy represents a promising strategy for the treatment of cancer, which functions via the reprogramming and activation of antitumor immunity. However, adverse events resulting from immunotherapy that are related to the low specificity of tumor cell-targeting represent a limitation of immunotherapy’s efficacy. The potential of nanotechnolog...
Peptide receptor radionuclide therapy (177Lu‐DOTATATE) causes DNA strand breaks and has been validated for well‐differentiated neuroendocrine tumors treatment. Poly‐(ADP‐ribose)‐polymerase inhibitors have also been used for malignant tumors with deficient DNA repair. We aimed to determine if the poly‐(ADP‐ribose)‐polymerase inhibitor fluzoparib cou...
A Visua l Functi ona l Gra ding Sca le for SRS Images as Noninvasive Indirect
Marker of Net Histopath ology (Abstract): Introduction: In the neuroendocrine
tumors management, the accurate monitoring of the radiotracer biodistribution and tumors dimensions are vital. We have created a visual functional grading scale, which could better classify the...
Although neuroendocrine tumours (NETs) are intensively studied, their diagnosis and consequently personalised therapy management is still puzzling due to their tumoral heterogeneity. In their theragnosis algorithm, receptor somatostatin scintigraphy takes the central place, the diagnosis receptor somatostatin analogue (RSA) choice depending on labo...
SOMATOSTATIN RECEPTORS SCINTIGRAPHY PRIORITIZATION CRITERIA BASED ON NET PATIENT EPIDEMIOLOGICAL PROFILE: A BI-CENTRIC STUDY (Abstract): This study aimed to create a generic profile of patients with NETs and to establish the priori-tization criteria for somatostatin receptors scintigraphy (SRS), within the NETs diagnostic algorithm, being the first...
This study aimed to create a generic profile of patients with NETs and to establish the prior i-tization criteria for somatostatin receptors scintigraphy (SRS), within the NETs diagnostic algorithm, being the first study of this kind conducted in Romania. Material and methods: A bi-centric, retro-prospective study comprising 103 patients with NETs,...
Cardiac amyloidosis is a protein deposition disease characterized by the infiltration of the myocardium and coronary arteries resulting in a progressive thickening of both ventricles, interatrial septum and atrioventricular valves, eventually leading to organ failure. It is a disease hard to diagnose, due to the lack of diagnostic investigations. H...
Cancer immunotherapy has shifted the paradigm in cancer treatment in recent years. Immune checkpoint blockage (ICB), the active cancer vaccination and chimeric antigen receptor (CAR) for T-cell-based adoptive cell transfer represent the main developments, achieving a surprising increased survival in patients included in clinical trials. In spite of...
New Quantitative Nuclear Functional Imaging Data In Nets Theragnostic Approach
BACKGROUND In neuroendocrine tumors (NETs) theragnostic, somatostatin receptor imaging represents gold standard in NETs management algorithm. Our study aims to establish new quantitative functional parameters, within the theragnostic approach of NETs patients. METHOD We...
Noncoding RNAs (ncRNAs) include a diverse range of RNA species, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). MiRNAs, ncRNAs of approximately 19–25 nucleotides in length, are involved in gene expression regulation either via degradation or silencing of the messenger RNAs (mRNAs) and have roles in multiple biological processes, inc...
Gastrin-secreting tumors, hypergastrinemia and severe ulcer disease form the trademarks of Zollinger-Ellison syndrome (ZES). We report a case of gastrinoma, in a patient who was misdiagnosed for almost five years. The case emphsizes the the special role of functional imaging in the personalized approach to the patient with suggestive symptomatology...
Background/objective:
Data regarding the nephrotoxicity of the peptide receptor radionuclide therapy (PRRT) with Yttrium- and Lutetium-radiolabeled somatostatin analogs (RSA) are inconclusive. We aimed to evaluate the short- and long-term nephrotoxicity following PRRT usage in patients with all types of neuroendocrine tumors (NETs).
Methods:
A s...
Citations
... Although OVs have exhibited encouraging outcomes in clinical trials across different cancer types, overcoming resistance to their therapeutic effects remains a challenge. Integrating OVs with conventional treatments like chemotherapy, immunotherapy, targeted therapies, and cellular therapies is crucial for augmenting response rates [505]. Cellular vaccines, including DC therapy and CAR-T therapy, play a crucial role in enhancing anti-tumor immunity by harnessing remarkable abilities for antigen recognition, processing, presentation, and T-cell sensitization [506]. ...
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... Along with this, one major quality control concern related to accelerator produced 225 Ac via spallation of 232 Th is an impurity of long lived 227 Ac. Various purification methods are being tested to separate the 227 Ac from 225 Ac [18,85,94]. ...
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... In adult humans, the existence of functional BAT was primarily recognised through the application of 18 FDG PET/CT [9,42]. When it comes to glucose metabolism, it appears that the very high metabolic activity of normally metabolically inactive fat tissue is what finally convinced the scientific community to recognise BAT as an organ of interest for energy balance, along with its possible therapeutic effects on obesity and type 2 diabetes [9,14,43]. ...
... In adult humans, the existence of functional BAT was primarily recognised through the application of 18 FDG PET/CT [9,42]. When it comes to glucose metabolism, it appears that the very high metabolic activity of normally metabolically inactive fat tissue is what finally convinced the scientific community to recognise BAT as an organ of interest for energy balance, along with its possible therapeutic effects on obesity and type 2 diabetes [9,14,43]. ...
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... Mutations in specific genes can significantly impact gene expression patterns and contribute to the development of diseases. In the context of colon cancer, localization of mutations in specific genes can disrupt normal gene expression patterns and contribute to tumor development [20]. ...
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... В клинической практике ПЭТ с 68 Ga-DOTATATE применяется для диагностики нейроэндокринных опухолей [7]. В отличие от него, 177 Lu-DOTATATE -это терапевтический препарат [8][9][10]. Его распределение в организме мыши с модельной опухолью B16F10 было изучено методом ОФЭКТ/КТ. ...
... An antibody-dye conjugate is injected, which is subsequently activated using a certain wavelength of light. RM-1995 is an antibody that specifically targets CD25, a receptor more often expressed by regulatory T cells than other cell types (95). This treatment method targets regulatory T cells within tumors (96) and becomes activated when exposed to red light, resulting in increased anticancer immune response. ...
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... Even the uptake of the 99m Tc tracer is lower in some lesions compared to the liver uptake, our opinion is that these lesions should be considered in the complete imaging analysis for a future treatment with radiolabeled somatostatin analogs -peptide receptor radionuclide therapy (Stolniceanu et al., 2021). our analysis showed that the semiquantitative analysis of SRS uptake can contribute to increasing the accuracy of the diagnosis of visual evaluation of SRS lesions. ...
... which stops and destroys cancer cells [105][106][107]. The favorable attributes of self-assembled peptide structures, including their bioavailability and biodegradability, coupled with their ability to release drugs in a controlled manner, position these structures as promising candidates for application in this field of research. ...
... Emerging biomarkers are also being investigated to inform personalized treatment approaches. 76 ...
