Cathy Anne Pinto's research while affiliated with Merck & Co. and other places

... Moreover, the patient-centric approach is being advocated in the context of BR assessment through the meticulous collection of patient preferences (Smith et al., 2016;Janssens et al., 2023). PV physicians are encouraged to actively collaborate with healthcare professionals, patients, and advocacy groups to ensure patientcentric approaches to drug safety. ...

... It offers an efficient and costeffective sample if this is an important criterion. 43 However, a general population might not be appropriate where weights may be required (e.g., MARs or market share) among potential patients. It might be plausible to assume than the general population sample provides lower MARs that a patient population does. ...

... Immune cells respond to this oxygen deficiency by activating a series of hypoxia-inducible factors (HIFs) (113). Both HIF-1a and HIF-2a have been shown to physically interact with the hypoxia response element (HRE) in the promoter region of PD-L1 (83,114). ...

... In a study of patients receiving palliative chemotherapy for advanced bile duct cancer, poor ECOG PS was associated with shorter OS [37]. Similar results were obtained in patients with advanced melanoma [38]. ...

... [1,2] Stroke is the leading cause of chronic disability, with an increasing burden on patients and society. [1,3] Management of stroke leads to an improved prognosis due to recanalization and restoration. [4][5][6] Nevertheless, primary prevention remains the most effective means of reducing the stroke burden. ...

... The most important research priorities identified were related to four high-level concepts: evidentiary standards, assessment of preference heterogeneity, means to minimize patient burden, and means to maximize patient understanding of concepts presented in preference studies. These were used to guide the research questions addressed in ten PREFER case studies that provided evidence to support recommendations on when and how to execute health preference studies [12][13][14][15][16][17][18][19][20][21][22]. ...

... There are few data on the impact of factors such as support from family or friends on preference for treatment. In a consensus study that drew on systematic reviews and input from experts, social support was relegated to the category of "inconclusive" with no data available [6]. ...

... There are small numbers of patients, and they can present with considerable phenotypic and genotypic heterogeneity, so finding a significant number of individuals that would fit within inclusion criteria of a clinical trial can be challenging. Stakeholders such as industry and regulators are therefore increasingly seeking input from patients in order to advance understanding the disease and the patient community's needs [15]. ...

... When designing the survey instruments, additional evidence such as a literature review and experience-based opinions from the key members of the team (patients, clinical experts, and methodological experts) were also considered. More details regarding these qualitative findings were reported elsewhere [26,27]. These findings showed that 11 attributes were eventually narrowed down to six final attributes that were included in the DCE and BWS-2 as minimizing the cognitive burden was key: muscle strength, energy endurance, balance, cognition, chance of (temporary) blurry vision, and chance of (permanent) liver damage. ...

... Additionally, the comparison of different methods for preference elicitation, study of nondiscrete choice experiment methods, and the consistency of preference outcomes from different methods were highly prioritized topics in the previous exercise. In the current study, this topic remained an important topic with indications that while additional research has been done in these areas since the first prioritization exercise [23,[50][51][52][53], more research would help to understand which method to choose when conducting a preference study. Interestingly, the topic of stability of preferences over time was previously ranked as least important, but in this updated exercise it was considered the second most important research topic. ...