Carlos Canelo-Aybar's research while affiliated with IR-Sant Pau - Sant Pau Institute of Biomedical Research and other places
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Publications (67)
Introduction
Patients’ decisions on prostate cancer (PCa) opportunistic screening may vary. This study aimed to assess how demographic and health-related characteristics may influence knowledge and decisions regarding PCa screening.
Methods
A cross-sectional survey was conducted among men aged over 40, randomly sampled from the Spanish population,...
To inform the clinical practice guidelines' recommendations developed by the European Academy of Allergy and Clinical Immunology systematic reviews (SR) assessed using GRADE on the impact of environmental tobacco smoke (ETS) and active smoking on the risk of new‐onset asthma/recurrent wheezing (RW)/low lung function (LF), and on asthma‐related outc...
Self‐management interventions (SMIs) may improve disease management in adults living with obesity. We formulated evidence‐based recommendations for SMIs within the context of the COMPAR‐EU project. The multidisciplinary panel selected critical outcomes based on the COMPAR‐EU core outcome set and established decision thresholds for each outcome. Rec...
Systematic review using GRADE of the impact of exposure to volatile organic compounds (VOCs), cleaning agents, mould/damp, pesticides on the risk of (i) new‐onset asthma (incidence) and (ii) adverse asthma‐related outcomes (impact). MEDLINE, EMBASE and Web of Science were searched for indoor pollutant exposure studies reporting on new‐onset asthma...
Self-management interventions (SMIs) offer a promising approach to actively engage patients in the management of their chronic diseases. Within the scope of the COMPAR-EU project, our goal is to provide evidence-based recommendations for the utilisation and implementation of SMIs in the care of adult individuals with type 2 diabetes mellitus (T2DM)...
Air pollution is one of the biggest environmental threats for asthma. Its impact is augmented by climate change. To inform the recommendations of the EAACI Guidelines on the environmental science for allergic diseases and asthma, a systematic review (SR) evaluated the impact on asthma‐related outcomes of short‐term exposure to outdoor air pollutant...
Self-management interventions (SMIs) may enhance heart failure (HF) outcomes and address challenges associated with disease management. This study aims to review randomized evidence and identify knowledge gaps in SMIs for adult HF patients. Within the COMPAR-EU project, from 2010 to 2018, we conducted searches in the databases MEDLINE, CINAHL, Emba...
Background:
Chronic diseases are a leading cause of global morbidity and mortality. In response to this challenge, self-management interventions (SMIs) have emerged as an essential tool in improving patient outcomes. However, the diverse and complex nature of SMIs pose significant challenges in measuring their effectiveness. This work aims to inve...
Self-management interventions (SMIs) may be promising in the treatment of Diabetes Mellitus Type 2 (T2DM). However, accurate comparisons of their relative effectiveness are challenging, partly due to a lack of clarity and detail regarding the intervention content being evaluated. This study summarizes intervention components and characteristics in...
Background:
This is the 23rd in a series of articles describing the GRADE approach to grading the certainty of evidence and strength of recommendations for systematic reviews, health technology assessments, and clinical guideline development.
Objectives:
We outline how resource utilization and cost-effectiveness analyses (CEAs) are integrated in...
Objectives:
To conduct an evidence map on self-management interventions and patient-relevant outcomes for adults living with overweight/obesity.
Methods:
Following Arksey and O'Malley methodology, we searched in five electronical databases including randomized controlled trials (RCTs) on SMIs for overweight/obesity. We used the terms "self-manag...
Limited number of studies have focused on the impact of pollen exposure on asthma. As a part of the EAACI Guidelines on Environment Science, this first systematic review on the relationship of pollen exposure to asthma exacerbations aimed to bridge this knowledge gap in view of implementing recommendations of prevention. We searched electronic iPub...
Aims:
Nurse-led case management (CM) may improve quality of life (QoL) for advanced heart failure (HF) patients. No systematic review (SR), however, has summarized its effectiveness/cost-effectiveness. We aimed to evaluate the effect of such programs in primary care settings in advanced HF patients. We examined and summarized evidence on QoL, mort...
Background: Opportunistic prostate-specific antigen (PSA) screening may reduce prostate cancer mortality risk but is associated with false positive results, biopsy complications and overdiagnosis. Although different organisations have emphasised the importance of shared decision making (SDM) to assist men in deciding whether to undergo prostate can...
An evidence-based approach is considered the gold standard for health decision-making. Sometimes, a guideline panel might judge the certainty that the desirable effects of an intervention clearly outweigh its undesirable effects as high, but the body of supportive evidence is indirect. In such cases, the application of the Grading of Recommendation...
Objectives
To evaluate the development and quality of actionable statements that qualify as good practice statements (GPS) reported in COVID-19 guidelines.
Design and setting
Systematic review . We searched MEDLINE, MedSci, China National Knowledge Infrastructure (CNKI), databases of Grading of Recommendations Assessment, Development and Evaluatio...
Rationale, aims and objectives:
In the context of a pandemic, the rapid development of clinical practice guidelines (CPGs) is critical. The guideline development process includes prioritization of the guideline topic, questions and health outcomes. This case study describes the application of a new methodology to prioritize questions and rate the...
Background
Although mammography screening is recommended in most European countries, the balance between the benefits and harms of different screening intervals is still a matter of debate. This review informed the European Commission Initiative on Breast Cancer (BC) recommendations.
Methods
We searched PubMed, EMBASE, and the Cochrane Library to...
Objective:
To explore and characterize published evidence on the ways decision analysis has been used to inform shared decision-making.
Study design and setting:
For this scoping review, we searched five bibliographic databases (from inception until February 2021), reference lists of included studies, trial registries, a thesis database and webs...
Background
Vitamin D has been widely promoted for bone health through supplementation and fortification of the general adult population. However, there is growing evidence that does not support these strategies. Our aim is to review the quality and recommendations on vitamin D nutritional and clinical practice guidelines and explore predictive fact...
Introduction
The Informed Health Choices (IHC) project developed learning resources to teach primary school children (10 to 12-year-olds) to assess treatment claims and make informed health choices. The aim of our study is to explore the educational context for teaching and learning critical thinking about health in Spanish primary schools.
Method...
Objective:
To evaluate the impact of preoperative MRI in the management of Ductal carcinoma in situ (DCIS).
Methods:
We searched the PubMed, EMBASE and Cochrane Library databases to identify randomised clinical trials (RCTs) or cohort studies assessing the impact of preoperative breast MRI in surgical outcomes, treatment change or loco-regional...
Introduction
The Informed Health Choices (IHC) project developed learning resources to teach primary school children (10 to 12-year-olds) to assess treatment claims and make informed health choices. The aim of our study is to explore the educational context for teaching and learning critical thinking about health in Spanish primary schools.
Method...
This systematic review evaluates the efficacy and safety of biologicals for chronic rhinosinusitis with nasal polyps (CRSwNP) compared with the standard of care. PubMed, Embase, and Cochrane Library were searched for RCTs. Critical and important CRSwNP‐related outcomes were considered. The risk of bias and the certainty of the evidence were assesse...
Background:
Diagnostic mammography projections (DxMM) have been traditionally used in the assessment of women recalled after a suspicious screening mammogram. Digital breast tomosynthesis (DBT) reduces the tissue overlap effect, thus improving image assessment. Some studies have suggested DBT might replace DxMM with at least equivalent performance...
Objectives
Mammography screening is generally accepted in women aged 50–69, but the balance between benefits and harms remains controversial in other age groups. This study systematically reviews these effects to inform the European Breast Cancer Guidelines.
Methods
We searched PubMed, EMBASE and Cochrane Library for randomised clinical trials (RC...
Background
Predicting the risk of recurrence and response to chemotherapy in women with early breast cancer is crucial to optimise adjuvant treatment. Despite the common practice of using multigene tests to predict recurrence, existing recommendations are inconsistent. Our aim was to formulate healthcare recommendations for the question “Should mul...
This systematic review evaluates the efficacy and safety of biologicals for chronic rhinosinusitis with nasal polyps (CRSwNP) compared to the standard of care. Pubmed, EMBASE and Cochrane Library were searched for RCTs. Critical and important CRSwNP-related outcomes were considered. The risk of bias and the certainty of the evidence were assessed u...
Background:
Breast cancer (BC) clinical guidelines offer evidence-based recommendations to improve quality of healthcare for patients with or at risk of BC. Suboptimal adherence to recommendations has the potential to negatively affect population health. However, no study has systematically reviewed the impact of BC guideline adherence -as prognos...
This systematic review evaluates the efficacy, safety and economic impact of dupilumab compared to standard of care for uncontrolled moderate‐to‐severe atopic dermatitis (AD). Pubmed, EMBASE and Cochrane Library were searched for RCTs and health economic evaluations. Critical and important AD‐related outcomes were considered. The risk of bias and t...
Objectives: The objective of the study is to present the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) conceptual approach to the assessment of certainty of evidence from modeling studies (i.e., certainty associated with model outputs). Study Design and Setting: Expert consultations and an international multidisciplinar...
This systematic review evaluates the efficacy and safety of omalizumab for chronic spontaneous urticaria (CSU). PubMed, Embase, and Cochrane Library were searched for RCTs. Critical and important CSU‐related outcomes were considered. The risk of bias and the certainty of the evidence were assessed using GRADE. Ten RCTs including 1620 subjects aged...
Background:
In the scope of the European Commission Initiative on Breast Cancer (ECIBC) the Monitoring and Evaluation (M&E) subgroup was tasked to identify breast cancer screening programme (BCSP) performance indicators, including their acceptable and desirable levels, which are associated with breast cancer (BC) mortality. This paper documents th...
Background
In Latin America, the prevalence of end-stage kidney disease (ESKD) has risen tremendously during the last decade. Previous studies have suggested that receiving dialysis at high altitude confers mortality benefits; however, this effect has not been demonstrated at >2000 m above sea level (masl) or in developing countries.
Methods
This...
Objective
To develop a pragmatic tool to prioritize clinical guideline (CG) questions for updating the UpPriority tool.
Study design and Setting
The development of this tool consisted of: 1) establishment of the working group, 2) generation of the initial version, 3) optimization of the tool (including an initial feasibility test, semi-structured...
Purpose:
Clinical guidelines' (CGs) adherence supports high-quality care. However, healthcare providers do not always comply with CGs recommendations. This systematic literature review aims to assess the extent of healthcare providers' adherence to breast cancer CGs in Europe and to identify the factors that impact on healthcare providers' adheren...
Allergic asthma is a frequent asthma phenotype. Both IgE and type 2 cytokines are increased, with some degree of overlap with other phenotypes. Systematic reviews assessed the efficacy and safety of benralizumab, dupilumab and omalizumab (alphabetical order) vs standard of care for patients with uncontrolled severe allergic asthma. PubMed, Embase a...
Background: A key impact measure of COVID-19 pandemic is the case fatality rate (CFR), but estimating it during an epidemic is challenging as the true number of cases may remain elusive.
Objective: To estimate the CFR applying a delay-adjusted method across countries, exploring differences to simple methods and potential correlation to country leve...
Five biologicals have been approved for severe eosinophilic asthma, a well-recognized phenotype. Systematic reviews (SR) evaluated the efficacy and safety of benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab (alphabetical order) compared to standard of care for severe eosinophilic asthma. PubMed, Embase and Cochrane Library were searc...
Background
Vitamin D has been widely promoted for bone health through supplementation and fortification of the general population. However, there is growing evidence that does not support these strategies. Our aim is to review the quality and recommendations on vitamin D nutritional and clinical practice guidelines and explore predictive factors fo...
Dupilumab, a fully human monoclonal antibody against interleukin‐4 receptor α, is approved as add‐on maintenance treatment for inadequately controlled type 2 severe asthma. This systematic review evaluated the efficacy, safety and economic impact of dupilumab compared to standard of care for uncontrolled severe asthma. PubMed, EMBASE and Cochrane L...
Five biologicals have been approved for severe eosinophilic asthma, a well‐recognized phenotype. Systematic reviews (SR) evaluated the efficacy and safety of benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab (alphabetical order) compared to standard of care for severe eosinophilic asthma. PubMed, Embase and Cochrane Library were searc...
Introduction
Population ageing and increasing chronic illness burden have sparked interest in innovative care models. While self-management interventions (SMIs) are drawing increasing attention, evidence of their efficacy is mostly based on pairwise meta-analysis, generally derived from randomised controlled trials comparing interventions versus a...
Description:
The European Commission Initiative for Breast Cancer Screening and Diagnosis guidelines (European Breast Guidelines) are coordinated by the European Commission's Joint Research Centre. The target audience for the guidelines includes women, health professionals, and policymakers.
Methods:
An international guideline panel of 28 multid...
Objectives
To investigate men’s values and preferences regarding prostate-specific antigen (PSA)-based screening for prostate cancer.
Design
Systematic review.
Data sources
We searched MEDLINE, EMBASE, PsycINFO and grey literature up to 2 September 2017.
Eligibility criteria
Primary studies of men’s values and preferences regarding the benefits...
Clinical practice guidelines are one of the main tools used by modern health systems and health professionals who practice evidence-based medicine. They are instruments used to benefit the patient and have a positive impact on health systems. Its development has evolved into reliable and widely used tools, and several concepts have been included in...
Purpose
Double reading is the strategy of choice for mammogram interpretation in screening programmes. It remains, however, unknown whether double reading is still the strategy of choice in the context of digital mammography. Our aim was to determine the effectiveness and cost-effectiveness of double reading versus single reading of digital mammogr...
Plagiarism is a serious, yet widespread type of research misconduct, and is often neglected in developing countries. Despite its far-reaching implications, plagiarism is poorly acknowledged and discussed in the academic setting, and insufficient evidence exists in Latin America and developing countries to inform the development of preventive strate...
There has been a regulation for generating clinical practice guidelines in Peru since 2005 (NT N° 027-MINSA/DGSP-V.01), which was issued by the Ministry of Health. However, its use has had little emphasis in the methodological quality of such guidelines, and a narrative style was preferred. Some isolated efforts aiming to improve the quality of suc...
In order to assess the methodological quality of clinical practice guidelines (CPG) developed by the Ministry of Health (MoH) of Peru, 17 CPGs published between 2009-2014 were evaluated by three methodological experts independently using the AGREE II instrument. The scores on AGREE II domains were low and very low in all GPC: scope and purpose (med...
Citations
... Several systematic reviews (SR) were conducted. [10][11][12] Multiple studies have shown an association between outdoor air There is moderate certainty evidence that exposure to damp/mould increases the risk of new-onset wheeze. 11 Exposure to cleaning agents may be associated with a higher risk of new-onset asthma and with asthma severity, while exposure to pesticides and VOCs may increase the risk of new-onset asthma. ...
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... La evidencia acumulada demuestra que múltiples intervenciones para el cambio de conducta ayudan a cambiar los comportamientos relacionados con la salud y a mantener esos cambios 13 , siendo las intervenciones para el cambio de conducta más intensivas las que se asocian con más beneficios y una mayor duración de ellos en el tiempo. Las intervenciones individuales sobre un solo factor de riesgo tienen escaso impacto en la salud de las personas y sus determinantes, por lo que se aconseja el abordaje integral de las conductas susceptibles de cambio para mejorar el estilo de vida 14 . ...
Reference: Fomento del autocuidado
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... Several systematic reviews (SR) were conducted. [10][11][12] Multiple studies have shown an association between outdoor air There is moderate certainty evidence that exposure to damp/mould increases the risk of new-onset wheeze. 11 Exposure to cleaning agents may be associated with a higher risk of new-onset asthma and with asthma severity, while exposure to pesticides and VOCs may increase the risk of new-onset asthma. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281220793829-1706596440281_Q64/Ioana-Agache.jpg)
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... Several systematic reviews (SR) were conducted. [10][11][12] Multiple studies have shown an association between outdoor air There is moderate certainty evidence that exposure to damp/mould increases the risk of new-onset wheeze. 11 Exposure to cleaning agents may be associated with a higher risk of new-onset asthma and with asthma severity, while exposure to pesticides and VOCs may increase the risk of new-onset asthma. ...
... We conducted three different analyses on the comparative effectiveness and safety of SMIs: standard pairwise MA, NMA, and CNMA, which is an extension of NMA to explore components' effects separately [39][40][41]. In the pairwise MA, we compared all SMI vs. UC for all critical and important outcomes. ...
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... The population was defined as adult patients with T2DM, regardless of the severity of the condition, presence of comorbidities, or any other risk factor for developing complications. The population characteristics, along with other features of studies included in the SR, are detailed in a descriptive analysis published elsewhere [31]. Briefly, across all studies, participants were predominantly female (mean 57%, SD 49-67%), with a mean age of 58 years and an average time since diagnosis of 8.6 years. ...
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... The methods of research for the etiology(s), prevention and treatment strategies of NCDs has been thoroughly developed from various descriptive epidemiological studies to forthcoming cohort studies [14][15][16]. This prospective number of studies include identifying the population sample, clinically assessing the sample and monitoring the sample for several years for any signs of noncommunicable disease [16]. ...
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... As compared to the European Code, and considering that ∼10% of the cancer burden in the LAC region is attributed to infections, new recommendations include discussing with healthcare professionals the benefits of screening and treatment of infections due to Helicobacter pylori, hepatitis B and C viruses, and human immunodeficiency virus, and practicing safe sex. 10 Other new recommendations include limiting drinking very hot beverages, avoiding outdoor air pollution and indoor air pollution when cooking and heating with coal and wood, and alerting on e-cigarettes as a gateway for non-smokers to initiate tobacco use. 7,11 Table 1 summarizes the specific recommendations for LAC with the main reasoning behind them. ...
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... As compared to the European Code, and considering that ∼10% of the cancer burden in the LAC region is attributed to infections, new recommendations include discussing with healthcare professionals the benefits of screening and treatment of infections due to Helicobacter pylori, hepatitis B and C viruses, and human immunodeficiency virus, and practicing safe sex. 10 Other new recommendations include limiting drinking very hot beverages, avoiding outdoor air pollution and indoor air pollution when cooking and heating with coal and wood, and alerting on e-cigarettes as a gateway for non-smokers to initiate tobacco use. 7,11 Table 1 summarizes the specific recommendations for LAC with the main reasoning behind them. Each of the 17 recommendation of the Code is accompanied by actions for policymakers to establish the infrastructure needed to enable the public to adopt them. ...
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... International recommendations are unanimous and concordant in justifying breastfeeding up to the child's second birthday, with exclusive breastfeeding up to 6 months of age. Breastfeeding is the only exclusive food recommended for newborns up to 6 months of age by the WHO and EFSA [59,60]. Moreover, considering the environmental contaminants present in breast milk, it becomes crucial to pursue environmental and dietary strategies to minimize exposure. ...
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