Carl-Johan Treutiger's research while affiliated with Karolinska Institutet and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (8)
Extracellular High Mobility Group Box 1 (HMGB1) has been associated with acute and chronic inflammatory conditions. However, little is known about HMGB1 in necrotizing bacterial infections. We hypothesized that the local HMGB1 response is excessive in severe soft tissue infections (STIs), which are characterized by necrosis and hyperinflammation. T...
Introduction:
Early risk assessment is the mainstay of management of patients with sepsis. APACHE II is the gold standard prognostic stratification system. A prediction rule that aimed to improve prognostication by APACHE II with the application of serum suPAR (soluble urokinase plasminogen activator receptor) is developed.
Methods:
A prospectiv...
Introduction
Rapid detection of, and optimized treatment for, severe sepsis and septic shock is crucial for successful outcome. Heparin-binding protein (HBP), a potent inducer of increased vascular permeability, is a potentially useful biomarker for predicting outcome in patients with severe infections. Our aim was to study the systemic release and...
The concept of neutrophil activation and degranulation as important contributors to disease pathology in invasive group A streptococcal infections has recently been emphasized. This study focuses on two of the most severe streptococcal manifestations, toxic shock syndrome and necrotizing fasciitis, and the newly described proinflammatory molecule r...
Citations
... Several studies have shown that GAS NSTIs are characterized by high bacterial load and a hyper-inflammatory response characterized by a massive infiltration of immune cells, including neutrophils and macrophages, and elevated levels of pro-inflammatory molecules [14,15,26,27,33,42]. The ability of GAS to cause hyperinflammation and tissue damage can be attributed to an arsenal of virulence factors. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/273511889502235-1442221724786_Q64/Linda-Johansson-7.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272743455260691-1442038515627_Q64/Anna-Norrby-Teglund.jpg)
... The placebo group receiving saline was devoid of beneficial effect of early initiation of antibiotic as all the patients recruited were treated as per sepsis protocol. This hold more significance especially when earlier studies have shown suPAR > 12 ng/mL independent predictor of unfavorable outcome or death in the first 28 days for patients with infection [2]. Is it ethical to deprive 1st dose in view of available literature? ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/273539371671573-1442228276726_Q64/George-Dimopoulos-2.jpg)
... During E. coli pneumonia, E. coliderived LPS may reach the liver from the lung by circulation and induce the production of inflammatory cytokines. Moreover, certain adipocytokines, including leptin and resistin, have been reported to act as proinflammatory cytokines [31,32] and be potential to regulate the process of apoptosis. The leptin exerted anti-apoptotic effect on hepatocytes during acute liver injury in rats [33], as well as resistin [34]. ...
... Several guidelines have elucidated the role of HBP in the early diagnosis and prognosis of sepsis [38]. Therefore, HBP is primarily utilized as a potential biomarker for sepsis [39,40]. Compared to PCT and CRP, HBP exhibits earlier and more sensitive elevation, making it imperative to develop faster and more portable detection methods for this marker [41]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/475727201083396-1490433611641_Q64/Adam-Linder.jpg)
... Several studies have shown that GAS NSTIs are characterized by high bacterial load and a hyper-inflammatory response characterized by a massive infiltration of immune cells, including neutrophils and macrophages, and elevated levels of pro-inflammatory molecules [14,15,26,27,33,42]. The ability of GAS to cause hyperinflammation and tissue damage can be attributed to an arsenal of virulence factors. ...
