Candace A. Frerich's research while affiliated with New Mexico Department of Health and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (6)
Adenoid cystic carcinoma (ACC) is an aggressive salivary gland tumor that frequently displays perineural invasion and is often associated with translocations or overexpression of the MYB oncogene. Detailed analyses of MYB transcripts from ACC patient samples revealed that ACC tumors utilize an alternative MYB promoter, which is rarely used in norma...
Adenoid cystic carcinoma (ACC) of the salivary gland is a rare head and neck malignancy with poor long-term prognosis. Hallmark chromosomal translocations result in MYB to NFIB (t(6;9)) and MYBL1 to NFIB (t(8;9)) gene fusions. Gene rearrangement and aberrant expression of the MYB and MYBL1 genes, along with the encoded transcription factors, are th...
The relative rarity of salivary gland adenoid cystic carcinoma (ACC) and its slow growing yet aggressive nature has complicated the development of molecular markers for patient stratification. To analyze molecular differences linked to the protracted disease course of ACC and metastases that form 5 or more years after diagnosis, detailed RNA-sequen...
Chromosomal translocations involving the MYB and NFIB (t(6;9)) genes are the sole recurrent cytogenetic aberration in Adenoid Cystic Carcinoma (ACC), a rare cancer that frequently manifests as salivary gland tumors. Since ACC has poor prognosis and treatment is accompanied by high morbidity, there is a need for additional investigation of this canc...
Unlabelled:
Adenoid cystic carcinoma (ACC), the second most common malignancy of salivary glands, is a rare tumor with a bleak prognosis for which therapeutic targets are unavailable. We used RNA sequencing (RNA-seq) to analyze low-quality RNA from archival, formaldehyde-fixed, paraffin-embedded samples. In addition to detecting the most common AC...
Citations
... The genes are proto-oncogenes and strong transcriptional activators that play a role in cell survival, proliferation, and differentiation, all events that are key to cancer progression [1]. Data showed that a loss-of-function of the c-MYB gene in adult hematopoietic stem cells led to impaired proliferation and accelerated differentiation [2,3], and truncations in the gene led to oncogenesis [4]. The MYBL2 gene regulates cell cycle progression, cell differentiation and survival [5], as does MYBL1, which is also a master regulator of male meiosis [6]. ...
... Numerous translocations are found within the MYB or MYBL1 genes. These cause shortening and subsequent overexpression of these genes and their product molecules [21]. Therefore, proteins such as MYB or A-MYB, triggered by C-terminal truncations, can cause a unique tumor phenotype of ACC. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272388210294801-1441953818765_Q64/Scott-Ness.jpg)
... Diffuse astrocytoma, MYB-or MYBL1-altered, is a diffusely infiltrative astroglial neoplasm with genetic alterations in MYB or MYBL1 (CNS WHO grade 1) [1]. MYB and MYBL1 are transcription factors encoded by members of the MYB gene family, and are important for cell proliferation [3]. Truncated versions of these proteins result from structural rearrangement of the responsible genes, with subsequent overexpression and tumorigenesis [4]. ...
Reference: Pediatric-type diffuse low-grade gliomas
