Caley A Hogan's research while affiliated with University of Wisconsin–Madison and other places
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Publications (3)
Post-transcriptional modification of RNA regulates gene expression at multiple levels. ALKBH8 is a tRNA modifying enzyme that methylates wobble uridines in specific tRNAs to modulate translation. Through methylation of tRNA-selenocysteine, ALKBH8 promotes selenoprotein synthesis and regulates redox homeostasis. Pathogenic variants in ALKBH8 have be...
Nervous system function rests on the formation of functional synapses between neurons. We have identified TRMT9B as a new regulator of synapse formation and function in Drosophila. TRMT9B has been studied for its role as a tumor suppressor and is one of two metazoan homologs of yeast tRNA methyltransferase 9 (Trm9), which methylates tRNA wobble uri...
Nervous system function relies on the formation and function of synaptic connections between neurons. Through a genetic screen in fDrosophila for new conserved synaptic genes, we identified CG42261/Fid/ TRMT9B as a negative regulator of synaptogenesis. TRMT9B has been studied for its role as a tumor suppressor in multiple carcinomas and is one of t...
Citations
... From these analyses, we identified the tRNA-methyltransferase AlkBH8 as a potential novel therapeutic target in CRC, as high AlkBH8 expression correlates with decreased overall survival in CRC patients ( Figure 5A-B). AlkBH8 has been extensively reported to regulate the selenoproteome via methylation of tRNA-selenocysteine, with AlkBH8 knockdown and knockout models demonstrating a decreased ability to translate selenoproteins [54][55][56][57][58][59][60][61] . We observed that AlkBH8 expression is significantly increased in tumor tissue as compared to normal controls ( Figure 5C), and that patients with early-onset CRC have increased expression of AlkBH8 as compared to all other age groups ( Figure 5D). ...
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... Animals and plants express orthologs of yeast Trm9 that are encoded by the AlkB homolog 8 (ALKBH8) and tRNA methyltransferase 9B (TRMT9B) genes (39)(40)(41)(42)(43)(44)(45). ALKBH8 and TRMT9B contain a Class I S-adenosyl-L-methionine (SAM)-dependent methyltransferase domain, similar to yeast Trm9. ...
