C. Schardt's scientific contributions

... Compared with the negative control group, Sheibani et al. [25] found that G-CSF used twice per day for 7 days in a TBI mouse model produced minimal benefits on cognitive performance with similar motor impairment. Another study also found that acute use of G-CSF did not ameliorate the size of contusion, brain edema, and glutamate concentrations in cerebrospinal fluid in a rat model of TBI [26]. In contrast, a recent study showed that 3 days use of G-CSF in post-TBI mice significantly improved both motor and cognitive disability at the 2-week follow-up; this behavioral improvement was attributed to increased neurogenesis in the hippocampus, increased recruitment of microglia and astrocytes, and upregulation of the neurotrophic factor BDNF [21]. ...