Bryon A. Nicholson's research while affiliated with Iowa State University and other places
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Publications (5)
The Clermont scheme has been used for subtyping of Escherichia coli since it was initially described in early 2000. Since then, researchers have used the scheme to type and sub-type commensal E. coli and pathogenic E. coli, such as extraintestinal pathogenic E. coli (ExPEC), and compare their phylogenetic assignment by pathogenicity, serogroup, dis...
Neonatal meningitis Escherichia coli (NMEC) is a common agent of neonatal bacterial meningitis, causing high neonatal mortality and neurologic sequelae in its victims. Here, we present the complete genome sequence of NMEC O18 (also known as NMEC 58), a highly virulent (O18ac:K1, ST416) strain.
Avian-pathogenic Escherichia coli (APEC) is the causative agent of colibacillosis, a disease that affects all facets of poultry production worldwide, resulting in multimillion dollar losses annually. Here, we report the genome sequence of an APEC O18 sequence type 95 (ST95) strain associated with disease in a chicken.
Heat map of the ExPEC-like NMEC accessory genome.
Strains containing listed genes are shown in red, absent genes are shown in black. The plasmid accessory genome contained a large number of hypothetical genes, genes of unknown function, phage genes, and insertion sequences. Other notable genes in the accessory genome included tsh the temperature se...
Citations
... It has been reported that most of virulence genes are often located on large IncF-type plasmids, such as IncFIB/IncFIC 1 (Wyrsch et al., 2022), which are generally named ColV (encoding colicin V) plasmids (Johnson et al., 2006a). According to a previous literature, the ColV plasmid was shown to be strongly associated with extra-intestinal pathogenic E. coli (ExPEC) (Logue et al., 2017). Meanwhile, Kim and his colleagues reported that virulence genes on ColV plasmids, such as hlyF, ompT, iroN, iss, and iutA, are associated with Avian pathogenic E. coli (APEC) (Kim et al., 2020). ...
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... We excluded the sequences UTI-98-1111, UTI-98-1112, UTI-98-1113, UTI-98-1114, UTI-98-1115, and UTI-89-1116 (Supplementary Figure S5, tab UTI89, marked yellow) from potential candidates because they showed homology to the E. coli O18ac:H14 genome. This is probably representative of the NMEC [16] sub-pathotype, but we did not find sufficient confirmation for this particular H serotype. These results are summarized in Table 3 Therefore, these fragments can be used to develop multiplex-PCR kits or dot-blot hybridization systems that distinguish both ExPEC and IPEC and also, to some extent, allow differentiation within the pathotype. ...
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... Strains and plasmids are shown in Table 1. The WT APEC strain was isolated from the pericardium of a chicken with signs of colisepticemia, and the sequenced genome is available at CP006830.1 (Nicholson et al., 2016). The O serogroup was identified at the E. coli reference center at Pennsylvania State University. ...
