Brenna S. Hefley's research while affiliated with University of North Texas HSC at Fort Worth and other places
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Publications (4)
This study investigated the interplay between transforming growth factor beta (TGF-β1/T1 and TGF-β3/T3), and sex hormone receptors using our 3D in vitro cornea stroma model. Primary human corneal fibroblasts (HCFs) from healthy donors were plated in transwells at 106 cells/well and cultured for four weeks. HCFs were supplemented with stable vitamin...
Exosomes are a group of vesicles that package and transport DNA, RNA, proteins, and lipids to recipient cells. They can be derived from blood, saliva, urine, and/or other biological tissues. Their impact on several diseases, such as neurodegenerative, autoimmune, and ocular diseases, have been reported, but not fully unraveled. The exosomes that ar...
Extracellular vesicles (EVs) are lipid-bound vesicles that originate from the endosomal system or budded off from the plasma membrane. EVs are involved in cell-cell communication via transporting DNA, RNA, and proteins from one cell to another. Tear EVs (tEVs) have been reported in dry eye, Sjӧgren's Syndrome, and primary open-angle glaucoma. In th...
Citations
... Since exosomes carry mRNA, miRNA, long noncoding RNA, DNA, nucleic acids, and proteins of the hepatitis B virus, they can accurately and specifically reflect the epigenetic status of recipient cells and the liver immune microenvironment [113]. Almost all cells can secrete exosomes, which are present in most body fluids, such as blood, cerebrospinal fluid, urine, ascites, lotions, saliva, and others [114][115][116]. Exosomes' noninvasive, accurate, specific, and widespread nature makes them more clinically feasible as biomarkers for hepatitis B-related liver disease [117]. ...
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... Many studies have employed this technology to investigate the percentage of EV markers including tetraspanins or essential therapeutic receptors/growth factors. These studies have been vital in identifying EV markers for cancer diagnostics, elucidating the function of biomarkers, and revealing key insights into EV biogenesis pathways [66][67][68][69]. However, few studies in the literature have taken advantage of this technology's potential for use in EV surface conjugation analysis. ...
