Brenden Van Wyk's research while affiliated with University of Saskatchewan and other places

... IFNα involves modulation of both adaptive and innate immune response, activating monocytes, antigen presenting cells, macrophages, natural killer cells (NK) cells, T cells and B cells. Within the PBMCs of the bovine viral diarrhea virus (BVDV) infected animals, there are distinct patterns of kinase mediated signal transduction activity with respect to activation of classic IFN-activated signaling pathways like JAK-STAT and induce expression of IFNα and IFNγ (Wyk et al., 2016) [16] . In our study, on day 10, 18, 36 post AI IFNα levels were significantly more (p≤0.05) in comparison to control. ...

... Herein, we compared the effects of feed additives on the immune and metabolic health of birds that have been challenged with IBV and environmental cold stress, using performance metrics, the kinome peptide array technique and gene expression. The kinome peptide array uses species-specific and process-specific kinase target peptides printed on a glass array; these target peptides can be phosphorylated by active kinases in the biological samples (Arsenault et al., 2011;Daigle et al., 2014;Arsenault and Kogut, 2015). The phosphorylation of these peptides can be measured and visualized to determine changes in signaling cascades in a sample which may alter biological functions and activities (Arsenault and Kogut, 2015). ...