Bernd Grohe's research while affiliated with Lawson Health Research Institute and other places

... The formation of renal calculi is not completely understood, but is predicted to proceed along the path of crystal nucleation, growth, aggregation and fixation within the kidney, where the crystal can further grow into a macroscopic stone 16 . The presence of stone-forming substrates or inhibitors at any point in this process can promote or hamper crystal formation 17 . Randall's plaques or plugs -which are calcium phosphate deposits found in the papillary interstitium or collecting ducts, respectively -are hypothesized to serve as a nidus for crystal attachment and subsequent stone development 18 . ...

... 41 Studies [38][39][40] show that there is a point beyond which the buffering capacity of saliva becomes less effective in the dental remineralization process, thus requiring external assistance to restore oral conditions and DE/RE process balance. [42][43][44] The mechanism of action of Biosilicate occurs through the formation of silica gel, which occurs precisely in the presence of saliva. Thus, Biosilicate acts by amplifying, to some extent, the role of saliva, which is more clearly evident in the DE/RE process, while reducing the mineral recovery time after contact with demineralizing substances, without disrupting this system at the expense of dental structure. ...

... Some of the most common methods currently employed include extrusion, electrospinning, isoelectric focusing, flow-based methods, and magnetic approaches. [12][13][14][15][16][17] The magnetic alignment approach was first reported in 1983 but the field has evolved slowly due to challenges with collagen alignment mainly because of the low diamagnetic properties of collagen. 18 Recently, with the advent of magnetic particle-based approaches, there is renewed interest among researchers to develop magnetically aligned collagen scaffolds with lowlevel magnetic fields for tissue regeneration applications. ...

... Indeed, diets high in oxalate appear to be better avoided, particularly in individuals with calcium and magnesium deficiency such as osteoporosis, vitamin D deficiency and in people who tend to develop CaOx kidney stones or gall stones (Amalraj & Pius, 2017;Kikunaga, Ishit, Imada, & Takahashi, 1995;Williams, 1978;Wolf, Mannino, Hofmann, Nickoloff, & Edwards, 1982). It should be noted that due to the long reaction times in the oral cavity, some evidence suggests that calcium oxalate monohydrate (COM) is more likely to form on oral surfaces than the di-or trihydrate phase (Aggarwal, Tessadri, & Grohe, 2015;Gleberzon, Liao, Mittler, Goldberg, & Grohe, 2018). ...

... Also, we can see vibrations between 1013 and 1040 cm -1 in the spectrum and they correspond to characteristic V=O vibrations of amorphous VO2. And these have shifted with heat treatment in accordance with the literature (Ji et al., 2017;Zomaya et al., 2020;Li et al., 2022). We can clearly see from FTIR spectra that thermal treatment can change the bond structure of the thin films. ...

... VO 2 'nin sıcaklık değişimiyle birlikte büyük optik özellik değişikliklerini kullanan akıllı cam kaplamalar yazın yüksek sıcaklıklarda güneş ısısı ışınımlarını yansıtırken soğuk kış mevsiminde yakın kızılötesi ışığı geçirerek enerji tasarrufuna katkı sağlar (B. Li vd., 2020;Salamati, Kamyabjou, Mohamadi, Taghizade, & Kowsari, 2019;Zomaya, Xu, Grohe, Mittler, & Charpentier, 2019). Ancak VO 2 içerikli cam kaplamaların pratik uygulamalarında çok sayıda sorunla karşılaşmak mümkündür (Shen vd., 2021). ...

... All three polypeptide chains contain a large number of repeating sequence of (Gly-X-Y) n with n ranging from 337 to 343 where X and Y typically represent Proline (Pro) and Hydroxyproline (Hyp), respectively (Suurs et al. 2020). The three chains of type I collagen possess the left-handed helical configuration and the molecules form a right-handed triple-helical structure (Ambrock, Grohe, and Mittler 2019) in which glycine residues are buried in the protein's core, and residues X and Y exposes on surface of protein (Bhuimbar, Bhagwat, and Dandge 2019). Accordingly, Gly makes up almost one third of the total amino acids, about 12% for Pro, and about 10% for Hyp. ...

... Because of these residues, OPN can form crystal-polyelectrolyte interactions with positively charged crystal faces and directly influence stone size and morphology [15]. In vitro studies have confirmed that human and other mammalian OPN isoforms are potent inhibitors of COM crystallization [11,[16][17][18][19][20][21][22][23][24]. To further characterize the OPN-COM interaction, Grohe et al. [19] developed a 16-residue synthetic peptide of OPN denoted as P3, corresponding to amino acids 220-235 of rat bone OPN (pSHEp-STEQSDAIDpSAEK). ...

... Nanomaterials have shown immense potential as potent antimicrobials, exhibiting a reduced tendency for microbial resistance. Silver-based materials are commonly employed in this context due to their high antibacterial properties resulting from the presence of ionic silver [16][17][18][19]. Additionally, other materials such as antimicrobial peptide polymers [20][21][22][23][24], quaternary ammonium-functionalized nanomaterials, carbon dots, gold nanoparticle-based nanomaterials, and semiconducting nanomaterials have been actively explored to mitigate AMR [24][25][26]. ...

... Clinical reports have shown that depositions of type I and III collagen are important markers for the evaluation of myocardial fibrosis. When the expression levels of the two proteins are increased without coordination of their elevated ratio, left cardiac insufficiency may result [14]. Type I and III collagens are important components of the extracellular matrix of cardiomyocytes. ...