Berber Kapitein's research while affiliated with University of Amsterdam and other places
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Publications (13)
Background
The incidence of severe asthma exacerbations (SAE) requiring a pediatric intensive care unit (PICU) admission during the coronavirus disease 2019 (COVID‐19) pandemic (and its association with public restrictions) is largely unknown. We examined the trend of SAE requiring PICU admission before, during, and after COVID‐19 restrictions in A...
Context:
The negative effects of socioeconomic, environmental and ethnic inequalities on childhood respiratory diseases are known in the development of persistent asthma and can result in adverse outcomes. However, little is known about the effects of these disparities on pediatric intensive care unit (PICU) outcomes in respiratory diseases.
Obje...
Background – The incidence of pediatric asthma exacerbations during the COVID-19 pandemic has been evaluated; however, the incidence of severe acute asthma (SAA) requiring a Pediatric Intensive Care Unit (PICU) admission is unknown. Furthermore, we examined several factors which might influence this incidence, such as environmental triggers or chan...
Context – The negative effects of socioeconomic, environmental and ethnic inequalities on childhood respiratory diseases are known in the development of persistent asthma and can result in adverse outcomes. However, little is known about the effects of these disparities on pediatric intensive care unit (PICU) outcomes in respiratory diseases. Objec...
Introduction
The clinical phenotype of severe acute asthma at the Paediatric Intensive Care Unit (PICU) is highly heterogeneous. However, current treatment is still based on a ‘one size fits all approach’.
Areas covered
We aim to give a comprehensive description of the clinical characteristics of paediatric patients with severe acute asthma admitt...
Respiratory syncytial virus (RSV) bronchiolitis causes substantial morbidity and mortality in young children, but insight into the burden of RSV bronchiolitis on pediatric intensive care units (PICUs) is limited. We aimed to determine the burden of RSV bronchiolitis on the PICUs in the Netherlands. Therefore, we identified all children ≤ 24 months...
Rationale
Severe acute asthma (SAA) can be fatal, but is often preventable. We previously observed in a retrospective cohort study, a three-fold increase in SAA paediatric intensive care (PICU) admissions between 2003 and 2013 in the Netherlands, with a significant increase during those years of numbers of children without treatment of inhaled cort...
Citations
... Umfragen unter Studierenden auch in Deutschland stützen diese Forderungen [6]. International sind mehrere Rahmenwerke zu PHE entstanden, in mehreren Ländern sind erste Vorhaben zu Lernzielkatalogen und Integration in die Curricula von Gesundheitsberufen zu verzeichnen [7][8][9][10][11]; [URL 2 -3]. ...
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... Although advances have been made in defining clinical "phenotypes" (i.e., groups shared biological inflammatory mechanisms) in pediatric outpatient populations, this work has not extended to children with life threatening asthma who are admitted to the PICU. This is a major shortcoming since children admitted to the PICU for asthma vary in their age, response to treatment, chronic asthma severity classification, sensitivity to triggers, and exacerbation frequency 11,12 . For example, in one study, up to 16% of children who presented to the PICU with life threatening asthma were experiencing their first major asthma exacerbation and would be considered as having "mild" asthma in the outpatient setting 13,14 . ...
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... Kang et al., en un estudio multicéntrico evidenciaron que los niños menores de 2 años representan una proporción significativa de las admisiones en la UCI pediátrica relacionadas con el virus sincitial respiratorio 24 ; asimismo, Linssen et al., concluyeron en su investigación que la carga de bronquiolitis grave por VSR en las UCIP ha aumentado en los países Bajos con requerimiento de soporte respiratorio PCR SARS-CoV-2 n (%) 52 (2,9) Laboratorios clínicos n (%) 373 (20,9) Enfermedad Respiratoria Aguda J. M. Avendaño-Vanegas et al invasivo y no invasivo 25 . En nuestra investigación 13 pacientes requirieron ser ingresados posteriormente a UCIP lo cual corresponde al 1% del total de pacientes atendidos, de los cuales el 42,8% presentaban infección por VRS. ...
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... 10 The increased risk of ICU admission observed in children with asthma in our study was documented by a study conducted in Denmark, where it was found that having asthma symptoms for less than 1 week was a significant factor associated with higher odds of pediatric ICU admission. 11 Regarding the factors associated with increased mortality, lower age that is, less than 1 year was associated with increased odds of death. This is similar to a study where it was found that the mortality of pneumonia was the highest in patients less than 1 year old. ...
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... Dexamethasone has been proposed as an equivalent therapy to prednisolone for acute asthma exacerbations in pediatric patients. [9] Dexamethasone has a longer half-life and has been used safely in other acute pediatric conditions like croup, etc. ...
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... However, respiratory acidosis at admission could be related to treatment of failure. 8 In an another study involving patients who were treated with HFNC due to respiratory distress, it was shown that a baseline respiratory rate (RR) >90th percentile, pCO 2 >50 mmHg, pH<7.3 could predict HFNC failure. 7 Considering the increasingly widespread use of HFNC, it remains important to identify the factors that may predict failure in children. ...
