Beibei Zhou's research while affiliated with First Affiliated Hospital of China Medical University and other places

... Bacteria frequently alter or hide phage receptors on the cell surface to evade detection by phages; these are often lipopolysaccharides (LPS) (for gram-negative bacteria), capsule, or various surfacelocalized proteins. In response, selection for mutations in receptor-binding proteins (RBP) enables phages to use modified or alternative receptors [2][3][4]. But this is not the full picture. ...

... Many studies suggest the use of phages as an adjuvant with the antibiotic as an effective therapeutic strategy for treating infectious diseases caused by multidrug-resistant bacteria 33,34 . ...

... The optical density at 600 nm (OD 600 ) of culture supernatants was measured following low-speed centrifuga tion (1,000 × g for 5 min) to assess the mucoviscosity. Acidic polysaccharides were extracted and measured to quantify CPS as described previously (29). Briefly, 500 µL of the bacterial culture of log-phase was mixed with 100 µL of 1% ZWITTERGENT 3-14 detergent in 100 mM citric acid, followed by incubation at 50°C for 20 min. ...

... [4][5][6][7][8] In addition, many cases of hypervirulent CRBs have been reported worldwide, making CRBs a real threat to public health. [9][10][11] Furthermore, the World Health Organization (WHO) classified carbapenem-resistant Enterobacteriaceae, Pseudomonas aeruginosa (P. ...

... Due to the gradual increase in the tolerance of clinically isolated P. aeruginosa to CHG [21], new methods are needed to restore bacterial susceptibility to CHG. Numerous studies have reported the use of bacteriophage for controlling the growth of pathogenic bacteria in the environment [22,23]. ...

... Enterobacter cancerogenus is a Gram-negative anaerobe bacillus [1,2]. It is widely distributed in nature [3], and has been successfully isolated from insect Diprion pini (Hymenoptera, Diprionidae) [4] and Lutzomyia evansi (Diptera, Psychodidae) [5] and plant tomato (Solanum lycopersicum) [6] and rice (Oryza sativa) [7]. A few reports suggest that E. cancerogenus may be a potential pathogen infecting patient skin and soft tissues when a wound exists and cause human diseases such as sepsis [8,9]. ...

... The antimicrobial susceptibility was assessed to determine MICs of antibiotics and glabridin using the broth microdilution method. 7,9 The MICs were interpreted using CLSI 2023 guidelines. 10 ...

... Likewise, rifampicin (RMP) is another transcription inhibitor antibiotic used to treat various bacterial infections and is often used in combination with other antimicrobials for severe S. aureus infections. It inhibits bacterial transcription by binding to the β-subunit of the bacterial DNA-dependent RNA polymerase (RNAP), which is encoded by the rpoB gene and rifampicin resistance in S. aureus are closely related to mutations occurring in the rpoB gene [16,17]. Therefore, with the widespread drug resistance and treatment failures of commonly used antibiotics reported daily around the world, it is more necessary than ever to explore the need to find an alternative way to maximize the effectiveness of antibiotics (https:// www. ...