B Phillips-Bute's research while affiliated with Duke University Medical Center and other places

... Postoperative brain injury after CPB is strongly associated with short-and long-term outcomes [7], such as prolonged ICU and hospital stays, morbidity and mortality [2,29]. It had been indicated that 30-80% of discharge patients were diagnosed POCD, even 20-40% of patients experienced cognitive impairment for postoperative 6 months [30]. Therefore, effective treatment for brain injury is important for patients underwent CPB. ...

... One was excluded for reporting of intraoperative outcomes only with no postoperative analgesia outcomes reported [13]. Two were excluded due to retrospective or audit methodologies [14,15]. Screening of references yielded one extra study which was subsequently excluded due to lack of placebo control in an observational study [16]. ...

... Tissue adhesives have been used in the past for a wide range of applications, including wound and laceration closure [1], repair of gastric varices [2], incisional hernias [3], retinal detachment [4], and for securing epidural catheters [5]. They have numerous advantages over traditional sutures [6], with the potential to reduce complications associated with traditional methods for both the patient and doctor. ...

... Our present study has failed to confirm a neuroprotective benefit from perioperative lidocaine administration in cardiac surgery. In addition, another negative trial of lidocaine in brain protection during cardiac surgery was reported in abstract form by the Duke group [22], but in the absence of a full description, it is difficult to further interpret this result. Despite these results, caution should be exercised before completely discounting clinical neuroprotection by lidocaine because our study has several limitations. ...

... [70] Mathew et al., in a prospective study, found that profound haemodilution (haematocrit of 15-17%) was associated with greater cognitive decline 6 weeks after CABG surgery, especially in the elderly. [71] In infants, too, low haematocrits (21% or 28%) were associated with lower psychometric development one year after surgery. [72] The optimal haemoglobin during cardiac surgery is not known and varies depending on the temperature, age of the patient and other risk factors for ischaemic brain injury. ...

... 2 POCD can be related to reduced quality of life, 3 increased economic costs, 4 and long-term cognitive decline. 5 Several risk factors have been identified in the development of POCD, including preoperative factors (eg, age, depression, cognitive impairment), intraoperative factors (eg, duration of surgery), and postoperative factors (eg, delirium). 6,7 POCD often appears at a subclinical level and thus remains unrecognized by physicians and family members. ...

... The remaining six publications of five trials used colloid solutions in their experimental and control arms, comparing a buffered hydroxyethyl starch (HES) solution versus a non-buffered HES solution. High molecular weight (MW) HES was used in four RCTs (Martin et al. 2002;Moretti et al. 2003;Gan et al. 1999;Wilkes et al. 2001), and two used low MW HES (Kulla et al. 2008;Base et al. 2011). ...

... While it was observed that individuals who were positively affected psychologically were mostly in the drug group, all variables were more positively affected in the group in which both apps were loaded. It was stated in a study that the problems experienced cannot be associated with psychological problems, and that patients who have had heart surgery may experience anxiety, depression and stress a year later [22,23]. In a study conducted using a similar measurement tool with patients with myocardial infarction, it was noted that the high normalizing evaluations of somatic evaluation were low [24]. ...

... In addition to the identified clinical risk factors for postoperative morbidity, genome variants were considered to be useful in the prediction of specific postoperative complications after cardiac surgery [14][15][16]. Genetic association studies in cardiac surgical cohorts reported that single-nucleotide variants (SNVs) of the interleukin 6 (IL6), intercellular adhesion molecule 1 (ICAM1), E-selectin (SELE), C-reactive protein (CRP), and lipopolysaccharide binding protein (LBP) genes were associated with perioperative myocardial infarction (MI), AKI, bleeding, or cognitive impairment after coronary artery bypass graft surgery [17][18][19][20][21]. Other complications, such as bacteremia, AKI, and ARDS, were reported to be associated with SNVs of nucleotide-binding oligomerization domain-containing protein 2 (NOD2), toll-like receptor 4 (TLR4), mannose-binding protein-associated serine protease 2 (MASP2), nitric oxide synthase 3 (NOS3), and tumor necrosis factor (TNF) genes in non-cardiac surgical intensive care unit (ICU) patients [22][23][24]. ...

... As Hextend has been shown to produce less coagulopathy compared to other similar non-blood colloids, the U.S. military Tactical Combat Casualty Care guidelines now recommend the use of Hextend when blood products are unavailable. 23,24 In our investigation of Hextend as a resuscitative fluid, we found no significant differences in mortality nor any differences in the subsequent physiologic and inflammatory responses. Our group has previously demonstrated similar findings in a porcine model of hemorrhage and laparotomy. ...