B Padmasri's research while affiliated with Sri Venkateswara College of Engineering and other places

Objective: To develop in-situ gel formulations of Lornoxicam for sustained release to reduce the dosing frequency in the treatment of rheumatoid arthritis. Methods: The method of ion-sensitive in-situ gel formation was used in this study. Lornoxicam in situ gel formulations were prepared by varying concentrations of sodium alginate as a bio-degradable gel-forming polymer, CaCl2 as a cross-linking agent, and chitosan, HPMCK4, HPMCK15, guar gum, gellan gum, xanthan gum, pectin were used as drug release rate controlling polymers. The formulations F11-F18 were assessed for physical appearance, pH, in vitro drug release, viscosity, in vitro gelling capacity, and drug content. FTIR, DSC, and in vivo drug kinetics studies were conducted for lornoxicam pure drug and optimized formulation. Results: Formulations showed an optimum viscosity that will allow ease of administration and swallowing. All formulations were shown pH between 6.7 to 7.3, floating lag time was 2-3 sec and floated for 12 h. In vitro, drug release studies were reporting that commercial sustained release formulation of lornoxicam released 99.92% drug in 8 h, and optimized formulation F11 released 99.52% of the drug over a 12 h extended period. FTIR studies revealed no interaction between drugs and excipients used. The results of in vivo kinetic studies are approving the better performance of the optimized formulation. The Cmax, Tmax, t1/2, and AUC values are confirming the same thing. Conclusion: Lornoxicam oral in situ gel containing chitosan as a drug release controlling polymer is a promising approach for the treatment of rheumatoid arthritis in a convenient dosage form with better patient compliance and therapeutic response.

In the present work, Almotriptan chewable tablets were prepared. All the tablets were subjected to weight variation, drug content uniformity, lock length, dissolution, drug excipients interaction and short-term stability studies. There was no difference in the position of the absorption bands, hence providing evidence for the absence of any chemical incompatibility between pure drugs with the excipients. The bulk density and tapped density for all formulation (F1-F9) varied from 0.423-0.485 gm/cm 3 and 0.501-0.593 gm/cm 3 respectively. The results of carr's consolidate index or % compressibility index and hausner's ratio for the entire formulation (F1-F9) blend range from 15.5-19.1 and 1.10-1.28 respectively, shows fair flow properties. All the tablets show similar color, odour, taste and physical appearance. There is no impact of different in their organoleptic properties. By using the different excipient, the hardness values ranged from 3.0-3.5 kg/cm 2 for formulations (F1-F9) .The entire tablet passes weight variation test, as the average % weight variation was within the Pharmacopeial limit-7.5%. It was found to be 149mg-152 mg. The weight of all the tablets was found to be uniform with less deviation. The concentration of the drug in all the formulations with different polymers was found to be 97.35-99.58%. It was within the IP limits.

In the present work, chewable release tablets of Darunavir were prepared by the wet granulation method. All the tablets were subjected to weight variation, drug content uniformity, and hardness, and friability, dissolution, drug excipients interaction and short-term stability studies. Tablets prepared by the wet granulation method were found to be good without any chipping, capping and sticking. The hardness of the prepared tablets was found to be in the range of 4.2 to 6.4 kg/ cm2. The friability values were found to be in the range of 0.63 to 0.81%. Disintegration time was found to be in the range of 1-3min.Formulation F7 showed good results than rest of the 9 formulations in pre and post compression studies. The average weight and drug content of the prepared tablets indicate weight and drug content uniformity within the batches prepared. Formulation F7 (99.266) displayed maximum drug release within 1 hour and also showed good hardness and friability results. IR-spectroscopic studies indicated that there are no drug-excipients interactions. The optimized formulation follows first order kinetics.

Hyaluronic acid also called as Hyaluronan, Sodium Hyaluronate (SA), sodium salt form of Hyaluronic acid is a biodegradable, biocompatible, and viscoelastic linear polysaccharide of a wide molecular weight range (1000 to 10,000,000 Da). In this project, described a method for preparing HA microspheres at different pH conditions by adapting a non-toxic and aqueous based crosslinking chemistry for sustained drug delivery of drugs. The derivatization chemistry of HA utilizing adipic dihydrazide has been used to construct hydrogels, applied for microsphere preparation. ADH was coupled efficiently to carbodimide-activated glucoronic acid residues of hyluronans. These ADH modified hyaluronan can be loaded with drug molecules and then cross linked into hydrogel. The drug was present in the bulk of hydrogel droplets which are present in liquid paraffin are precipitated by IPA. Formulating HA microspheres with this method have several advantages. Preliminary studies were conducted to confirm the better ratio of HA and ADH to show maximum entrapment efficiency and drug release. Then microspheres were prepared at different pH conditions and formulations were subjected to evaluation of various parameters like percentage yield, particle size, drug entrapment efficiency, porosity and bulk density, surface morphology, in vitro drug release among which F2B was optimized as best formulation which showed 74.6% entrapment efficiency and above 90% of drug release in 12 hours indicating Hyaluronic acid microspheres can be used as good carriers for sustained drug delivery of drugs.

An eco- friendly product has been the primary agenda of 21st century of the global scientists. Herbal cosmetics have growing demand in the global market. The aim of present work is to In-house preparation, development and evaluation of herbal cosmetics face pack using various natural powders for glowing skin by using natural Ingredients. The natural powders used are shade dried commercial turmeric, rice flour, gram flour, rose powder, tomato powder, orange peel powder. Sandalwood powder, milk powder, camphor powder were purchased form local market in the form of dried powder, all powdered natural ingredients were sieved using #120 mesh, weighed accurately and mixed geometrically for uniform preparation and evaluated for parameters including macroscopical, Physiochemical, irritancy, antimicrobial tests along with stability studies. Thus, in this work we formulate herbal face pack by using easily available ingredients. After evaluation, we found good flow properties, free from skin irritation and maintained proper stability storage conditions. Results of this study scientifically verified that herbal face pack having enough potential to give efficient glowing effect on skin. The overall study is useful to substantiate product claims due to its benefits on the human being. Keywords: herbal cosmetics, turmeric, Sandalwood powder, orange peel powder

Mankind's history is watching a bizarre time battling an imperceptible adversary, the novel COVID-19 Coronavirus. At first seen in the Wuhan province of China, presently limitlessly spreading all over world. How the COVID 19 has been made on the globe become Pandemic needs no depiction. The virus has been accounted for affecting the lungs and related respiratory tracts promoting harm of the alveoli. It has been accounted that the respiratory sickness is the prevailing Clinical symptom of COVID-19. This review article discusses an easily understanding of the causes, different type of Human viruses regarded of Coronavirus, clinical diagnosis of RT-PCR, FET, Primary prevention and control of the virus. Therefore, this review article main theme is to provide more reliable and valid information to control and manage public emergency in both acute and chronic conditions of coronavirus

Over the past three decades, orally disintegrating tablets(ODTs) have considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance. United States Food and Drug administration (FDA) defined ODT as " A Solid dosage form containing medicinal substance or active ingredient which disintegrates rapidly usually with in a matter of seconds when placed upon the tongue". Almotriptan is an extremely potent member of triptan class drugs which is widely used in the treatment of migraine. It shows high bioavailability, rapid action with fewer side effects when compared to other drugs of the same class. The present study is aimed to develop an oral disintegrating solid dosage form of Almotriptan which disintegrates rapidly without the need of water or chewing and release its drug instantaneously showing rapid action for sudden attacks of migraine with good patient compliance for all age groups. Crosspovidone & SSG were selected as super disintegrants. FTIR studies were carried out to confirm the drug excipients compatability. Pre compression evaluation tests and post compression evaluation tests were also carried out as the tablets are ODTs wetting time and water absorption studies were also carried out. The evaluation results confirmed that the crosspovidone is more suitable to SSG and Almotriptan can be best formulated as ODT using crosspovidone.