B Ann Hedley's research while affiliated with The University of Edinburgh and other places
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Publications (11)
Least squares discriminant analysis at reproduction EC50. Scores plot for PC1 and PC2 from PLS-DA of normalised whole genome microarray data for adult C. elegans raised on control NGM media or exposed to (a) Cd, (b) FA, and (c) AZ concentrations approximating to the reproduction EC50 for brood size.
Assessment of micro-array sensitivity and signal linearity. Representative analysis of the fluorescent signal generated by 10 RNAs introduced at known concentrations prior to labelling and detected by complementary reporter (10 replicates of each reporter spotted on the array). Data were generated from representative arrays selected from transcript...
Assessment of micro-array sensitivity and signal linearity. Representative analysis of the fluorescent signal generated by 10 RNAs introduced at known concentrations prior to labelling and detected by complementary reporter (8 replicates of each reporter spotted on the array). Panel A are data generated from Cadmium exposure of 40 mg/L array replic...
Assessment of micro-array sensitivity and signal linearity. Representative analysis of the fluorescent signal generated by 10 RNAs introduced at known concentrations prior to labelling and detected by complementary reporter (10 replicates of each reporter spotted on the array). Panel A are data generated from Cadmium control array replicate 4, pane...
Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene expression following exposure to three toxic chemicals: c...
Natural contamination and anthropogenic pollution of soils are likely to be major determinants of functioning and survival of keystone invertebrate taxa. Soil animals will have both evolutionary adaptation and genetically programmed responses to these toxic chemicals, but mechanistic understanding of such is sparse. The clitellate annelid Lumbricus...
Graphical representations of relative gene expression against fluorescence intensity from control and xenobiotic-exposed samples. Array data were normalised and filtered (as described in Materials and Methods) and the log2 of the average fold change (M) plotted against the log2 of the average mean signal intensity (A). Panel A shows a MA plot for c...
Transcripts significantly changed in adult earthworms exposed to cadmium. A table showing all transcripts identified as changing significantly in adult earthworms exposed to cadmium (ANOVA, p < 0.05, Benjamini and Hochberg False Discovery Rate)
Transcripts significantly changed in adult earthworms exposed to atrazine. A table showing all transcripts identified as changing significantly in adult earthworms exposed to atrazine (ANOVA, p < 0.05, Benjamini and Hochberg False Discovery Rate)
Transcripts significantly changed between adult and juvenile earthworms. A table showing all transcripts identified as changing significantly between adult and juvenile earthworms (T-test, p < 0.01, Bonferroni False Discovery Rate)
Citations
... The TD component of dynamic energy budget based models link internal exposure to effects on vital rates through five putative energetic or damage associated mechanisms, termed "physiological modes of action" (Kooijman and Bedaux, 1996;Alda Alvarez et al., 2006;Billoir et al., 2008;Swain et al., 2010;Ashauer and Jager, 2018). These five are: (1) Assimilation from food; (2) somatic and maturity maintenance; ...
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... During the 2000s, L. rubellus became a major research model earthworm in ecotoxicology and molecular biology (Stürzenbaum et al., 1998;Morgan et al., 2004;Owen et al., 2008;Guo et al., 2009). ...
... It has been reported that nanoplastics (Schultz et al., 2021) and fluoranthene (Swain et al., 2010) increased energy costs in C. elegans, resulting in impaired growth and reproduction. These results indicate that exposure to toxicants can lead to slow growth, which in turn can impair reproduction due to the smaller size of C. elegans. ...
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