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January 2008
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461 Reads
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8,449 Citations
Nature
We have mapped and quantified mouse transcriptomes by deeply sequencing them and recording how frequently each gene is represented in the sequence sample ( RNA - Seq ). This provides a digital measure of the presence and prevalence of transcripts from known ...
... The complex mechanism of aging encompasses genomic instability, telomere attrition, epigenetic alterations, proteostasis loss, disabled macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis [12]. Major advances in high-throughput sequencing technology [13,14] and mass spectrometry (MS)-based proteomics [15,16] have enabled the identification of products at various expression levels with increased accuracy and reproducibility. Thus, numerous studies have applied genomic, transcriptomic (including mRNA, miRNA, circRNA, and lncRNA), and proteomic assays (collectively termed "multiomics") in aging research [17,18]. ...
January 2008
Nature
