Atsushi Makino's research while affiliated with Aichi Children's Health and Medical Center and other places
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Publications (11)
Some food allergic patients who have undergone oral immunotherapy develop exercise-induced allergic reactions on desensitization (EIARDs). This study investigated basophil activation status during the exercise provocation test (EPT) performed to diagnose EIARD. EPT was performed on 20 participants, and in vivo basophil activation status was analyze...
The detailed mechanism of acetaminophen hypersensitivity remains unclear, but two sets of immunological and pharmacological mechanisms have been assumed. In addition, there are no reports of remission in cases in which an immunological mechanism is assumed without complications of hypersensitivity to other NSAIDs. Herein, we describe two cases of a...
Objective: Digested soy protein, the raw material of soy-based infant formula Bonlact® i, undergoes heat treatment and enzymatic processing, which may make it hypoallergenic. The purpose of this study is to confirm the allergenicity of Bonlact® i.
Methods: We performed SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting of digested...
Background:
There is reportedly a difference in the diameter of the skin reaction induced by different types of skin prick test (SPT) devices. We compared the SPT diagnostic accuracy and wheal size between a Bifurcated Needle® (BN) and SmartPractice® Prick Lancet (PL), which are commercially available in Japan.
Methods:
An SPT was performed on 1...
Background
The interval between antigen ingestion may influence the safety of oral food challenge tests (OFCs), especially in patients with severe food allergies.
Methods
This retrospective chart review of OFCs eliciting objective reactions to wheat, egg, and milk that were performed between April 2012 and January 2021 evaluated an equivalent numb...
Background
We examined the feasibility, efficacy and safety of slow low-dose oral immunotherapy (SLOIT) for egg, milk, wheat allergies, with accepted severity-stratified initial and maintenance doses.
Methods
Children with food allergies defined by low-dose oral food challenges (LD-OFCs) to hen's egg (cumulative protein dose up to 983 mg, n = 133)...
Introduction:
Immune response to cow's milk allergen (CMA) has been analyzed mostly using crude milk antigen or a mixture of various caseins. This study aimed to assess the changes in the immunological response against αS1-casein during oral immunotherapy (OIT) and to investigate the mechanism of tolerance.
Methods:
We have performed rush OIT to...
Citations
... Patients with severe CMA exhibit allergic reactions to CN phosphopeptide-containing products such as oral care products, chewing gums, topical creams, and toothpaste. 118 These findings suggest that partial cross-reactive epitopes, but not the entire sequential homology, play a vital role in the cross-antigenicity between CN fractions. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/982328557989892-1611216787828_Q64/Teruaki-Matsui-2.jpg)
... 4 Kitamura et al. reported that wheat OFCs at 60-min intervals are safer than those at 30-min intervals. 6 Late initial symptoms explain the reduced risk of adverse reactions with intervals longer than 30 min between doses, which may help in avoiding excessive intake. Indeed, in our study, 34% of the patients who underwent the milk OFC and 81% of those who underwent the F I G U R E 2 Minutes to symptom initiation, peak, and disappearance after single-medium-dose oral food challenges (OFCs). ...
... 3 However, a longer period between each dose escalation could reduce the risk for serious side effects. 11 Previously data showed no benefit for a high dose (3,000 mg peanut protein) compared with a low maintenance dose (300 mg peanut protein). 7 To date, there are no randomized controlled trials with peanut OIT for young children (aged 1-3 years) with a low maintenance dose and a slow up-dosing strategy to investigate whether this can lead to tolerance and less adverse events (AEs). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/678371348475911-1538747741529_Q64/Shiro-Sugiura.jpg)
... 44,114 Although amino acid sequence homology between as1-CNs and b-CN is quite low (4%), specific IgE levels between them were strongly correlated, and simultaneously decreased during CM oral immunotherapy. 115,116 Moreover, complete IgE inhibition was observed by b-CN against as1-CN in ELISA. The partial amino acid sequences of as1-CN (E61-E70) and b-CN (I12-E21) showed a low propensity distance value (5.30) under in silico analysis, 117 which suggests high sequential homology. ...
