Asma Alanazi's research while affiliated with King Saud bin Abdulaziz University for Health Sciences and other places
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Publications (9)
To investigate the effect of the therapeutic treatment of the immunopeptide, peptide inhibitor of trans-endothelial migration (PEPITEM) on the severity of disease in a mouse model of experimental autoimmune encephalomyelitis (EAE) as a model for human multiple sclerosis (MS), a series of experiments were conducted. Using C57BL/6 female mice, we dos...
Introduction: Diabetic nephropathy (DN), a chronic kidney disease, is a major cause of end-stage kidney disease worldwide. Mesenchymal stem cells (MSCs) have become a promising option to mitigate several diabetic complications.
Methods: In this study, we evaluated the therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) in...
Antibody phage display is a key tool for the development of monoclonal antibodies against various targets. However, the development of anti-peptide antibodies is a challenging process due to the small size of peptides for binding. This makes anchoring of peptides a preferred approach for panning experiments. A common approach is by using streptavid...
Chronic kidney disease (CKD), a global health concern, is highly prevalent among adults. Presently, there are limited therapeutic options to restore kidney function. This study aimed to investigate the therapeutic potential of breast milk mesenchymal stem cells (Br-MSCs) and their derived exosomes in CKD. Eighty adult male Sprague Dawley rats were...
Background
We investigated and compared the effect of the radiofrequency electromagnetic field (RF-EM) emitted by a cell phone on the electrocardiogram and heart rate variability (HRV) of normotensive normal-weight and obese medical students.
Method
Twenty medical student volunteers, normal weight (age = 23 ± 2, BMI = 23.05 ± 1.72) or obese (age =...
Background:
Mesenchymal stem cells (MSC) are used in therapy, often by injection into the blood.
Objective:
We aimed to compare the adhesive and migratory properties of MSC from umbilical cords (UCMSC), bone marrow (BMMSC) or trabecular bone (TBMSC), which might influence delivery to injured tissue.
Methods:
MSC were perfused through glass cap...
We investigated the adhesive behaviour of mesenchymal stem cells (MSC) in blood, which might influence their fate when infused as therapy. Isolated human bone marrow (BM) or umbilical cord (UC) MSC adhered efficiently from flow to the matrix proteins, collagen or fibronectin, but did not adhere to endothelial selectins. However, when suspended in b...
Citations
... A bioactive endogenous 14.3.3.ζδ-derived-Peptide cleaved from 14-3-3ξ protein has been identified, influencing endothelium dependent monocyte migration during inflammation (Alassiri & Al Sufiani, 2023;Chimen et al., 2015). However, the role of this 14.3.3.ζδ-derived-Peptide ...
... Furthermore, Ferrostatin-1 (a potent inhibitor of ferroptosis) treatment attenuated Ptec death in the adenine-induced cKD model by targeting the aforementioned ferroptosis pathway through the inhibition of lipid peroxidation, which further demonstrated that ferroptosis plays a more important role in the adenine-induced cKD model [143,177]. Notably, other types of programmed cell death, such as cellular apoptosis and autophagy, have also been reported in adenine-induced cKD ( Figure 6) [38,[178][179][180][181][182][183]. ...
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... Several studies have shown a connection between EMFs and HRV values [42,43], while others have observed no relationship [44][45][46]. Thus, studies have produced conflicting results. ...
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... Due to their rapid proliferation, strong adhesion, and migration capabilities, hUC-MSCs often form millimetre-sized aggregates before cell harvesting when microcarriers are poorly suspended. The formation of such aggregates introduces mass transfer limitations that impact cell viability and make cell digestion and isolation challenging (Ferrari et al. 2012;Alanazi et al. 2019;Zeddou et al. 2010; Luo et al. 2014). Increasing the impeller speed of spinner asks can enhance the degree of aggregate suspension and reduce the maximum size of aggregates (Jossen et al. 2016). ...
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... Platelet counts showed a downward trend in the old LC group. Sheriff et al 19 reported that MSCs can carry and activate platelets in the blood, and platelets might target MSCs to damaged tissue; platelet activation by MSCs in the circulating blood could cause thrombus formation and/or a reduction in the platelet count. Thus, platelet activation and platelet-derived mitochondria, which were found in the study of Levoux et al,7 could occur in liver tissue. ...
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