Ariane Auquier's research while affiliated with Institut de Cancérologie Gustave Roussy and other places
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Publications (47)
Omitted Confounding Variables Measurement Error The Regression Effect Specifying a Mathematical Model Sampling Error Separation of Groups on a Confounding Factor Summary
Categorical or Numerical Variables Comparison of Matching and Adjustment Procedures Combining Procedures
Definition of Randomization Properties of Randomization Further Points on Randomization Reasons for the Use of Nonrandomized Studies Types of Comparative Studies Our Attitude toward Nonrandomized Studies
Although case-crossover analyses have lately emerged as an alternative to case-control analyses in epidemiological studies, it is not yet known in which situations they give reliable conclusions. In this work, the case-crossover and the case-control designs were first compared on the basis of a dataset from a published study of severe cutaneous adv...
Although case–crossover analyses have lately emerged as an alternative to case–control analyses in epidemiological studies, it is not yet known in which situations they give reliable conclusions. In this work, the case–crossover and the case–control designs were first compared on the basis of a dataset from a published study of severe cutaneous adv...
There is still controversy about whether all antiepileptic drugs are associated with the severe cutaneous reactions Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). We have studied the role of antiepileptic drugs in SJS and TEN, taking into account potential cofactors that might confound or modify the risk.
The case-control stud...
Background
There is still controversy about whether all antiepileptic drugs are associated with the severe cutaneous reactions Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). We have studied the role of antiepileptic drugs in SJS and TEN, taking into account potential cofactors that might confound or modify the risk.
Methods
T...
This paper describes the design of E3N, a prospective cohort study conducted in France on risk factors for female cancers. The cohort comprises 100,000 women, aged 40-65 years at baseline in 1990. Participants were asked to complete questionnaires every 18 months. The main hypotheses studied concern the relationship between diet and cancer and betw...
This paper describes the design of E3N, a prospective cohort study conducted in France on risk factors for female cancers. The cohort comprises 100,000 women, aged 40-65 years at baseline in 1990. Participants were asked to complete questionnaires every 18 months. The main hypotheses studied concern the relationship between diet and cancer and betw...
Toxic epidermal necrolysis and Stevens-Johnson syndrome are rare, life-threatening, drug-induced cutaneous reactions. We conducted a case-control study to quantify the risks associated with the use of specific drugs.
Data were obtained through surveillance networks in France, Germany, Italy, and Portugal. Drug use before the onset of disease was co...
A recent meta-analysis using individual data from 54 trials included more than 9000 NSCLC patients in three adjuvant settings (surgery + chemotherapy (CT), surgery ± radiotherapy (RT) ± CT, radical RT ± CT) and in the supportive care setting. Of the 14 trials analysing the first adjuvant setting, only 7 including 1062 patients, used a cisplatin bas...
A multicenter international case-control study has been designed to elucidate the etiology of Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN). Although these diseases occur rarely, the morbidity is high and the mortality for TEN is of the order of 30%. These serious dermatologic conditions have often been linked to exposure to drugs....
The data from a French case-control study of 495 patients with breast cancer and 542 control subjects interviewed in five French public hospitals, were analyzed to assess the effect of reproductive factors (age at menarche, age at first full-term pregnancy, the time interval between these two ages, and parity) on the risk of breast cancer. Age at m...
One can read that one woman in 11 in France and one in nine in the USA will get breast cancer. This high risk is the result of the irrealistic assumption that all women remain exposed to the risk of breast cancer until age 90, and ignores the risk of death before that age. It is possible to allow for the occurrence of death before age 90. We descri...
The triangular test has been used to monitor survival data from a randomized trial in patients with small cell lung cancer. The results of consecutive interim analyses and the problems met by the data monitoring committee and the co-ordinators are described. The methods as well as the consequences of the early stopping on the analysis and the resul...
To date, the effect of tar exposure, the use of a filter and the type of tobacco (light or dark) on the risk of lung cancer have not been studied together.
Data from a case-control study on lung cancer were used to evaluate the specific effects of these three parameters. Cases of lung cancer and controls were interviewed in hospitals in France from...
In a case-control study of 495 breast cancer patients and 785 controls between 20 and 56 years of age, the risk of breast cancer associated with a family history of breast cancer was studied according to age and reproductive factors. The familial risk of breast cancer was not significantly modified by age at onset, age at menarche, number of childr...
The ability of adjuvant radiotherapy to prevent distant metastasis and to prolong survival in patients with early breast cancer is much debated. The paper presents a joint analysis of long-term results (13-16 years' follow-up) from the Oslo and Stockholm randomised trials of post-operative megavoltage radiotherapy versus surgery alone. Among node-p...
Between 1954 and 1983, 7620 patients were treated for breast carcinoma at Institut Gustave Roussy (France). Of these patients, 6919 were followed for at least 1 year. Out of these, 11 presented with sarcomas thought to be induced by irradiation, 2 of which were Steward-Treves Syndrome, and 9 of which were sarcomas within the irradiated fields. All...
In a case-control study, the relationship between a family history of cancer of the breast, ovary, colon, uterus or prostate and the risk of breast cancer was investigated. The data consisted of family histories from 495 breast cancer cases and 785 controls aged 20-56 years. A positive association was found between the occurrence of breast cancer a...
A total of 951 newly diagnosed patients with nonmetastatic rhabdomyosarcoma (RMS) under 21 years of age from four different cooperative study groups were analyzed to identify the most important pretreatment tumor characteristics in predicting survival. The patient characteristics considered were tumor invasiveness (T), tumor size, status of locoreg...
The role of the occupational environment in the occurrence of cancer of the pancreas was analysed in a case-control study of 171 cases of pancreatic cancer and 317 controls matched for age at interview, sex, hospital, and interviewer. The study was conducted in France between 1982 and 1985 and covered 15 important industries and various other occup...
In order to evaluate risk factors in male breast cancer, a case-control study of 91 histologically diagnosed cases and 255 cancer controls, matched for age and year of diagnosis, was conducted in Villejuif (France) and Geneva (Switzerland). Factors studied included marital history, occupational exposure, associated diseases, family history of breas...
Data from a case-control study on lung cancer were used to evaluate how changes in cigarette habits, mainly smoking cessation, switch from non-filter to filter brands, from dark to light tobacco, or from handrolled to manufactured cigarettes, and reduction in daily consumption influence lung cancer risk. The results presented concern all males, exc...
A hospital case control study on smoking, alcohol and coffee consumption as risk factors for pancreatic cancer, in which 161 cases were matched to 268 control patients, was conducted in France between 1982 and 1985. The results showed no association between tobacco or alcohol consumption and cancer of the pancreas, whereas coffee consumption was as...
A study of the prognosis of two series of chronic lymphocytic leukemia (CLL) patients (99 from a retrospective series and 196 from a prospective series) has led us to propose a three-stage classification (A, B, C), requiring only a clinical examination and a haemogram.
For stage A patients (comprising 50% of the CLL patients), survival rates are si...
Adjustment for a Confounding Factor Bias, Precision, and Statistical Significance Some Qualitative Considerations
When searching for histological prognostic factors-in Chronic Lymphocytic Leukemia (CLL) we focused on one aspect of the quality of the data, the agreement of slide readings between pathologists. A preliminary study allowed us to define a set of 10 useful items in the histology of CLL. The results of the main study which concerned 228 slides read b...
Survivals of two series of CLL patients (99 from a retrospective series and 196 from a prospective series) were studied separately. The three main staging systems (Rai, Binet, Rundles) agreed well, but as far as survival is concerned, too many stages are defined. The authors performed a Cox multivariate analysis of survival in order to isolate impo...
The physician has always had a great interest in prognostic knowledge: enability to predict the evolution, to better know the physiopathogical mechanism and to adapt treatment according to the prognostic status. This important medical need leads to perform numerous prognostic studies, sometimes coupled with clinical trials. Our experience in this f...
Staging has achieved wide acceptance in many types of cancer as a basis for therapeutic decisions. The highly variable course of Chronic Lymphocytic Leukemia (CLL) justifies adaptating treatment to the severity of the disease provided the existence of a good prognostic classification. Therapeutic progress is demonstrated by randomized trials planne...
The value of prognostic information and some of the statistical aspects of prognostic studies are discussed. In the first part, seven areas of medical activity where knowledge of prognostic factors is used are identified: prediction of disease evolution, treatment decisions, design and analysis of clinical trials, comparison of non-randomized serie...
Citations
... Each test was repeated (not less than five times) until the values had level of standard deviation not more than 2.5% (twice less that the maximum possible deviation of the equipment) of the average level of the actual test point. The statistical evaluation of results was made to evaluate the reliability of research results by calculating the actual parameters as average, variance, standard deviation and uncertainty of the input data (Anderson et al., 1980). To study the comparative assessment of the correlation of various parameters of gas flow rate at various cases, an analysis was performed using the Pearson index. ...
... SJS is a life-threatening hypersensitivity reaction usually caused by medications, but can occasionally occur due to infectious agents, vaccines, and even certain foods [5][6][7]. A study by Roujeau et al. in 1995 found an association between corticosteroid use and increased risk of SJS, which is counterintuitive given that SJS is likely immune-mediated, and corticosteroids are known to facilitate immunosuppression [7]. ...
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... The life table is a population model covering the simple case of a birth cohort, born at the same time period, closed to migration, and followed through successive ages until they die [9]. The life table assumes the homogeneity of cohorts (i.e., subjects have the same distribution of survival times) [10]. ...
... A confounding variable correlate both the predictor and also the outcome variables (Anderson, 1980;Frank, 2000). Hence, we use this confounding variable to perform the stratification method and, at a second stage, we analyse the outcome groups independently (Austin and Brunner, 2004;Austin, 2011;Ballestar, Grau-Carles and Sainz, 2019). ...
... If variables were not normally distributed we used Kruskal-Wallis-tests and post-hoc Mann-Whitney-U tests in order to compare differences between the groups. Instead of repeated measure ANOVAs, we used change scores as recommended by Fitzmaurice, Laird, and Ware (2004, p. 124) as they are preferable to repeated-measures ANOVAs in designs with two assessments per individual (Anderson, Hauck, Oakes, Vandaele, & Weisberg, 1980). Third, to test the moderation effect of proneness to psychosis on the relation between changes in loneliness and changes in state paranoia (H3), we used the PROCESS-macro by Hayes (2013). ...
... In 1990, participants signed an informed consent form in accordance to the French National Commission for Data Protection and Privacy. Part of this study is the French component of the European Prospective Investigation into Cancer (EPIC) [13]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281157089385-1683705588530_Q64/Marti-Van-Liere-2.jpg)
... Case-crossover was evaluated in the context of SJS/TEN already in an earlier study (Viboud et al., 2001). The authors reported good efficiency of the case-crossover estimates for the risk factors under investigation, but with a few exceptions. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/279105997164546-1443555463129_Q64/Pierre-Yves-Boelle.jpg)
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... The syndrome is characterized by extensive skin rash, eosinophilia, atypical lymphocytosis, and organ involvement [6]. Clinical manifestations are not immediate and typically appear within two to eight weeks after the introduction of the triggering drug [7]. The most common systemic involvement is hepatitis followed by nephritis, pneumonitis, myositis, and gastroenteritis [8]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/477891176734721-1490949544002_Q64/Osvaldo-Correia.jpg)
... For example, several case-control studies showed a DRG between coffee consumption and pancreatic cancer [23,24]. ...
... The debate about IMN radiation dates back 30 years when publications like Auguier et al. (2) analyzed the Oslo II and Stockholm postmastectomy randomized radiation trials conducted in the presystemic therapy era, which identified an interaction between regional nodal irradiation benefit and axillary lymph node status. Specifically, patients with positive axillary nodes who received regional nodal irradiation inclusive of the axillary, supraclavicular, and IMN had improved distant metastases-free survival. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272413095100425-1441959751132_Q64/Lars-Rutqvist.jpg)
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