Anning Song's research while affiliated with Minzu University of China and other places

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Publications (5)

Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl4-induced liver fibrosis in mice
Article
  • Nov 2023
EGT is a bioactive compound derived from certain edible mushrooms. Here, we showed that EGT inhibits HSC activation and improves CCl 4 -induced mouse liver fibrosis by promoting nuclear translocation of Foxa3 in HSCs to potentiate the Hint1/Smad7 axis.
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Ethanol Extract of Rosa rugosa Ameliorates Acetaminophen-Induced Liver Injury via Upregulating Sirt1 and Subsequent Potentiation of LKB1/AMPK/Nrf2 Cascade in Hepatocytes
Article
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  • Oct 2023
Acetaminophen (APAP)-induced liver injury is a common hepatic disease resulting from drug abuse. Few targeted treatments are available clinically nowadays. The flower bud of Rosa rugosa has a wide range of biological activities. However, it is unclear whether it alleviates liver injury caused by APAP. Here, we prepared an ethanol extract of Rosa ru...
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Theaflavine inhibits hepatic stellate cell activation by modulating the PKA/LKB1/AMPK/GSK3β cascade and subsequently enhancing Nrf2 signaling
Article
  • Aug 2023
Activation of hepatic stellate cells (HSCs) constitutes a crucial etiological factor leading to liver fibrosis. Theaflavine (TF) is a characteristic bioactive compound in fermented tea. Here, we found that TF attenuated the activation of LX-2 HSCs induced by transforming growth factor-β1 (TGF-β1). TF potentiated nuclear factor erythroid 2-related F...
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Citations

... The anti-inflammatory activities of GT, oBT and cBT were estimated by the ability to reduce the production of inducible notric oxide (iNOS) produced and the results are given in Fig. 3C. Theaflavine (TF) is a characteristic bioactive compound in fermented tea which helps in the activation of NRF-2 pathway, thereby reducing the liver inflammation (Shu et al. 2023). Theanine and γ-aminobutyric acid contents in the fermented tea suppressed the expression of inflammatory cytokines, as well as inhibited overexpression of apoptotic signals for the neuroprotective effects thorugh regulation of MAPK signaling . ...
Reference: Comparative studies on the antioxidant, anticancer and anti-inflammatory activities of green tea, orthodox black tea and CTC black tea
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... Five active polyphenols, including gallic acid, Di-O-galloyl-HHDP-glucoside, quercetin-3-O-sophoroside, kaempferol-3-O-sophoroside, and ellagic acid, were identified in ERS and analyzed quantitatively using mixed standards of these compounds as references (Figure 1). Data of our chemical composition exploration are comparable to those of previous reports [40][41][42], indicating the reliability of the process to prepare and analyze ERS. ...
Reference: Ethanol Extract of Rosa rugosa Ameliorates Acetaminophen-Induced Liver Injury via Upregulating Sirt1 and Subsequent Potentiation of LKB1/AMPK/Nrf2 Cascade in Hepatocytes
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