Anna Dominik's research while affiliated with Wyższa Szkoła Handlowa we Wrocławiu and other places

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Publications (2)

Figure 4. Macroscopic modeling indicates that β 2 L296V and α 1 G258V...
Figure 5. Macroscopic modeling indicates that the α 1 L300V mutation...
Figure 6. Single-channel activity reveals diversified effects of...
Mean Values of Parameters of Open Time Distribution
Mutations at the M2 and M3 Transmembrane Helices of the GABA A Rs α 1 and β 2 Subunits Affect Primarily Late Gating Transitions Including Opening/Closing and Desensitization
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  • Jun 2021
GABA type A receptors (GABAARs) belong to the pentameric ligand-gated ion channel (pLGIC) family and play a crucial role in mediating inhibition in the adult mammalian brain. Recently, a major progress in determining the static structure of GABAARs was achieved, although precise molecular scenarios underlying conformational transitions remain uncle...
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Interaction between GABAA receptor α1 and β2 subunits at the N-terminal peripheral regions is crucial for receptor binding and gating
Article
  • Nov 2020
Pentameric ligand gated ion channels (pLGICs) are crucial in electrochemical signaling but exact molecular mechanisms of their activation remain elusive. So far, major effort focused on the top-down molecular pathway between the ligand binding site and the channel gate. However, recent studies revealed that pLGIC activation is associated with coord...
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Citations

... 17 However, mutational studies have shown that single amino acid transmembrane domain mutations can either increase or decrease receptor desensitization. [20][21][22][23][24][25] Hence, there is no a priori reason that DEE-associated variants should only affect desensitization in one way. ...
Reference: Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severity
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... Given the rigid body movement of the subunit ECD beta barrels, it is natural to expect much of the dynamics to occur at the interfaces between subunits, which include the GABA and BZD binding sites [106]. Only one of the two GABA sites shares the same α subunit as the BZD site, raising the possibility that BZDs may induce local changes that preferentially modulate activation via a single GABA site. ...
Reference: Benzodiazepine Modulation of GABAA Receptors: A Mechanistic Perspective
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