Anna Carolina Rocha da Silva's research while affiliated with Universidade Estadual de Feira de Santana and other places
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Publication (1)
Sickle cell disease (SCD) is a disease resulting from mutation in the globin portion of hemoglobin caused by the replacement of adenine for thymine in the codon of the β globin gene. In Brazil, SCD affects about 0.3% of the black and Caucasian population. Until now, there is no specific treatment and the available drugs have several serious adverse...
Citations
... The binding mode of hA 2B AR was also analysed with the same docking protocols in Discovery Studio 2017 R2. The homology model of hA 2B AR was developed using a hA 2A AR crystal structure as the template (PDB ID: 6PS7) and has been checked using the Ramachandran plot application within Discovery Studio 40,41 . In the binding mode (Figure 4(b,d); for more details see Supporting information Figure S3), the pyridine scaffold is located at the entrance of the cavity getting close to residue Phe173 in the ECL2 segment, and the methylbenzonitrile moiety is located in the depth of the binding pocket by a p-p interaction with Trp247. ...
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