Anna Bazzicalupo's research while affiliated with Royal Botanic Gardens, Kew and other places

... On top of genomic variation, transcriptomic control of tolerance mechanisms such as e ux pumps, chelators, and ROS detoxi cation systems seems to play an important role in S. luteus Zn tolerance. Speci cally, metal tolerant isolates show very different gene expression patterns compared to sensitive isolates and are likely constitutively metal tolerant because of differential gene expression (Smith et al. 2023). It is yet unclear whether the Suillus isolates from Colorado follow a similar pattern of population structure, with one population of S. brevipes and another of S. tomentosus including sensitive and tolerant isolates. ...

... The past decades have seen great achievements in molecular techniques to decipher diversity (e.g. the use of e-DNA [20,21]), and new methodologies to detect, quantify and explore uncharted habitats, especially in the oceans. But despite these advances and improved global diversity compilations [18,22] and statistical techniques to estimate richness [23], we have to humbly recognize we do not know precisely how many and which species co-inhabit in any given ecosystem on Earth. Our most complete databases are taxonomically constrained assemblages (e.g. ...

... It may also indicate that these isolates belong to a population that might has experienced range expansions across the other two regions, which has resulted in admixture complemented by gene flow (Rogers and Rogers, 1999), gradually reducing the isolation by distance (Mills et al., 2007) of Fthiotida isolates. On the other hand, the extensive clustering into geographically-restricted lineages of isolates from Larissa and Pieria regions may indicate that these populations experienced a geographic isolation leading to local adaptation (Bazzicalupo, 2022). Future expansion of pan-genomic resources with a broader sampling to include surrounding regions or a globally-representative set of isolates of S. pistaciarum, might be able to confirm if isolates of the southern Fthiotida region represent a "wilder" population, relative those of the genetically narrower Pieria and Larissa regions. ...

... Le nombre réel pourrait néanmoins être beaucoup plus élevé compte tenu de la difficulté d'accès au territoire et du fait qu'il existe peu de données scientifiques pour plusieurs groupes taxinomiques (p. ex, invertébrés, algues, champignons) (Langor 2019;Bazzicalupo et al. 2022). ...

... 40%) and Basidiomycota (the remaining 60%). This finding aligns with the isolation of these phyla from spring soils reported by Bazzicalupo et al. (2022). Their study, conducted on geothermal soils sampled at Yellowstone National Park (USA), revealed the detection of species from the genus Talaromyces, which includes thermophilic and thermotolerant species (Houbraken et al., 2012). ...

... Within the genus, species grouped in the section Phalloideae are known to produce amatoxins and are the leading cause of fatal intoxication worldwide[28,85,86]. Nonetheless, some species of at least two other genera, Galerina and Lepiota, produce amatoxins and can cause hepatotoxicity comparable to the best-known species of the genus Amanita[87,88]. The toxins produced by these fungi are numerous and peptidic. They are essentially grouped into three chemical families: amatoxins, phallotoxins and virotoxins, all cyclopeptides with a tryptophan sulfur bond and some hydroxylated amino acids. ...

... Despite nearly 50 years of empirical and theoretical work, research has been dominated by regional studies and has been limited to much smaller size ranges than the 23 orders of magnitude originally conjectured [but see (36)]. Empirical size spectra have typically averaged a range in body mass of six orders of magnitude and have not exceeded 16 (5,7,8,10) (table S3). ...

... Physical, chemical, and biotic soil properties impose prominent selective pressures on individuals, populations, and communities. While heavy metal or salt tolerance has been widely studied in relation to plant [67][68][69] and fungi [70,71] adaptation, many other aspects still await consideration. Among these are acidification (which may indirectly affect toxic ion concentrations in soils), soil compaction (change in aeration), soil water content (drought stress related to precipitation, evapo-transpiration, and terrain), and biotic activity (micro-and macro-organisms). ...

... For example, S. bovinus displays Zn tolerance intraspeci c variation ( Previous research in Belgian S. luteus found that isolates from geographically distinct but relatively close sites (~ 20 km apart) display marked differences in their ability to tolerate soil metal contamination, generally correlating with metal contamination at the site of origin (Colpaert et al. 2000). Interestingly, even though these tolerant and sensitive isolates show genetic differentiation at genes involved in metal homeostasis, whole genome analyses indicated that they all belong to the same population, with differences in metal tolerance thought to be a result of standing genetic variation (Bazzicalupo et al. 2020). On top of genomic variation, transcriptomic control of tolerance mechanisms such as e ux pumps, chelators, and ROS detoxi cation systems seems to play an important role in S. luteus Zn tolerance. ...

... Comparative genomic analyses previously suggested that S. lacrymans were preadapted to the indoor conditions (Balasundaram et al., 2018) and it is likely that these adaptations occurred before the split of (Cresnar & Petric, 2011;Ichinose, 2013;Xu et al., 2015). For fungi, cytochrome P450 s were recently suggested to be involved in heavy metal tolerance in Suillus luteus (Bazzicalupo et al., 2019) and during pathogenic interactions between Heterobasidion annum and conifer trees (Karlsson et al., 2008). Wood type dependent difference in gene expression of cytochrome P450 s have previously been found for two wood decay species (Wymelenberg et al., 2011). ...