Anil Thomas's research while affiliated with Bharath University and other places
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Publications (8)
Colorectal cancer (CRC) is the third most common cancer; cancer biomarker discovery is important for disease detection and management. It is known that hyaluronic acid and its receptors are ubiquitously expressed in almost all human tissues. Earlier we have shown that a monoclonal antibody H11B2C2, presently known as UNIVmAb, reactive hyaladherin e...
Objective:
Management and diagnosis of multiple human cancers remains a challenge and search for a common biomarker is still debatable. In this manuscript we have evaluated the use of monoclonal antibody UNIVmAb, to detect the protein (H11) as a common biomarker for all cancers irrespective of the grade and origin. We have shown by both ELISA and...
Objective: Management and diagnosis of multiple human cancers remain a challenge and search for a common biomarker are still debatable. We described a method and evaluated the use of monoclonal antibody UNIVMab, to detect the protein (H11) as a common biomarker for all cancer irrespective of grade and origin . H11 protein identified as a unique Hya...
Objective: Management and diagnosis of multiple human cancers remain a challenge and search for a common biomarker are still debatable. We described a method and evaluated the use of monoclonal antibody UNIVMab, to detect the protein (H11) as a common biomarker for all cancer irrespective of grade and origin . H11 protein identified as a unique Hya...
Objective: Management and diagnosis of multiple human cancers remain a challenge and search for a common biomarker are still debatable. We described a method and evaluated the use of monoclonal antibody UNIVMab, to detect the protein (H11) as a common biomarker for all cancer irrespective of grade and origin . H11 protein identified as a unique Hya...
Unlabelled:
Tumour cells generate hyaluronan (HA) oligomers (O-HA) by an autocrine mechanism to regulate their own behaviour through receptor interaction, necessitating analysis of HA sizes and its receptor expression in tumour progression. In this study for the first time, we identified specific size of HA in malignant ovarian tumour compared to...
Hyaluronan (HA) is a component of extracellular matrix that influences cell-proliferation, migration, development, regeneration, normal tissue remodeling, tissues undergoing malignancy and tumor cell interaction. The widespread occurrence of HA binding proteins, their involvement in tissue organization and the control of cellular behavior are well...
Citations
... The images shown in Figure 4A,B correspond to the fluorescence intensity analysis for Hela cells incubated with MIPG_GA or NIPG_GA, respectively, indicating that the MIPG_GA specifically bound towards the epitope of hyaluronic acid on Hela cells. Our fluorescent probe is more convenient for commercializing due to its excellent stability, though less sensitive with respect to the hyaluronic acid-binding protein (HABP, Figure S6) [35][36][37]. Moreover, compared with nano-sized MIP containing quantum dots [28,29], our MIPG_GA is easier to fabricate using a broad-spectrum cross-linker FAM-based monomer for signaling, showing the universal utility of this strategy. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/928450634321920-1598371289301_Q64/Kolapalli-Srinivas.jpg)
... The validation phase also requires a number of patients defined through power analysis, and the number of biomarkers to be tested must also be considered. This can range from tens to thousands of patient samples, which are analyzed by immunological assays such as ELISA, immunohistochemistry, dot blot, Western blot, and others [13,15,66,99,100]. ...
... These experiments suggested that high molecular weight HA produced by ID8 cells promotes membrane cholesterol depletion in macrophages. Given that HA is an important component of ECM in many cancers, including EOC (Kolapalli et al., 2016), this suggests HA could affect the phenotype of TAMs through membrane cholesterol depletion. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272268324503578-1441925235621_Q64/Venkatrao-Nunna.jpg)
... Circulatory serum autoantibodies recognize relevant HABPs in patients with cancer, suggesting that autoantibody-based tests may be used to differentiate patient with cancer from inflammation and HC [19]. Immunoblot analysis identified 120 kD, 80 kD, 57 kD, 47 kD and 37 kD as major HABPs and their relevant autoantibodies in patient with cancer and these proteins are directly associated with bioactive fragments or polymer HA and are involved in cell proliferation, cell-cell adhesion, differentiation and migration during tumorogenesis [20], and also these multiple HABPs (Hyaladherins) are known to be directly associated with metastasis and reported to play a vital role in carcinogenesis [14]. The over expression of HABPs were observed during tumorigesis but, not in HC. ...
... Biotinylated hyaluronic acid was prepared according to Boregowda et al. [13] and Srinivas et al. [24]. In brief, HA dissolved in PBS-A was dialyzed in MES buffer and reacted with biotin_LC-hydrazide and EDC in DMSO. ...
