Andrew Padalhin's research while affiliated with Dankook University and other places
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Publications (20)
This study investigates the efficacy of a thermo-responsive N-acetylcysteine (NAC) hydrogel on wound healing and oral ulcer recovery. Formulated by combining NAC with methylcellulose, the hydrogel’s properties were assessed for temperature-induced gelation and cell viability using human fibroblast cells. In vivo experiments on Sprague Dawley rats c...
Background
Oral ulcers are a common side effect of chemotherapy and affect patients’ quality of life. While stem cell transplantation is a potential treatment for oral ulcers, its efficacy is limited as the stem cells tend to remain in the affected area for a short time. This study aims to develop a treatment for oral ulcers by using trimethyl chit...
Wound management practices have made significant advancements, yet the search for improved antiseptics persists. In our pursuit of solutions that not only prevent infections but also address broader aspects of wound care, we investigated the impact of integrating trimethyl chitosan (TMC) into a widely used poly(vinylpyrrolidone)-iodine gel (PVP-I g...
Objective: The submandibular gland (SMG) produces the most saliva, and factors such as aging and chemotherapy can affect its structure and function. However, there are only temporary treatments available for salivary hypofunction. This study aimed to evaluate the effects of photobiomodulation (PBM) on the function of SMG by using a rat animal model...
In this study, the effect of photobiomodulation (PBM) treatment using 630 nm light emitting diode (LED) array (continuous wave type, 10 mW power) on tonsil-derived mesenchymal stem cells (TMSCs) and its interaction with RAW 264.7 macrophage cells via co-culture in vitro were investigated. PBM treatment was used as a priming method for TMSCs to impr...
This study investigated photobiomodulation (PBM) effects in Sonic hedgehog (Shh) signaling as a potential approach to taste preservation and regeneration. Primary taste cell (TC) cultures were treated with Shh antagonist Vismodegib and irradiated using a continuous wave type 630 nm light-emitting diode (10 mW/cm2 ) array, with single or multiple do...
Background
Numerous studies have noted the effect of chorda tympani (CT) nerve transection on taste sensitivity yet very few have directly observed its effects on taste receptor and taste signaling protein expressions in the tongue tissue.
Methods
In this study, bilateral CT nerve transection was performed in adult Sprague Dawley rats after establ...
At a time of unpredictable challenges for health, one trend is certain: there is an exceedingly high demand for functional implants, particularly bone grafts. This has encouraged the emergence of bone tissue engineering substitutes as an alternative method to conventional bone grafts. However, the current approaches in the field face several limita...
Lavage or irrigation has been instilled in surgical practice for wound clearance and surgical site infection prevention during and after surgery. Herein, we developed a new irrigation solution using trimethyl chitosan (TMC), a quaternized chitosan derivative. The TMC-saline irrigation solution developed in the study possesses highly effective bacte...
Objectives
The effect of photobiomodulation (PBM) treatment on wound healing and macrophage polarization was investigated in vivo. Animal models of oral ulcers were simulated through chemically induced oral ulcers in rats.
Materials and Methods
PBM treatment using an infrared pulsed laser was used to treat oral ulcers in the animal models. Twelve...
Electrospinning is a well-known technique for the production of fibers from a range of hundreds of micrometers to a 10th of nanometers. This technique is simple, versatile, cost-effective, high production rate, and very relevant in industry and biomedical research. In this chapter, we have highlighted the basics of electrospinning with apparatus se...
Citations
... Owji et al. conducted in vivo studies to examine neo-bone formation at 4-and 8-week post-implantation, as shown in Fig. 8. The quantitative micro-CT and histological examination results showed that bone formation was not faster in CaP-filled CSMA composites compared to CSMA alone [123]. ...
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... A potentially effective approach is to target and rectify the underlying cellular and molecular factors that are responsible for this persistent inflammation, with the aim of restoring the wound to a healing state [3]. To gain insights into the healing state of the wound, it becomes imperative to quantify various pro-inflammatory (TNF-α, IL-1β, IL-6, etc.) and anti-inflammatory (TGF-β, IL-10, IL-13, etc.) cytokines [4][5][6][7]. ...
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... This demonstrates a remarkable capacity for rapid wound healing following traumatic injury. Moreover, saliva in the oral cavity contains elevated levels of lysozyme and hyaluronic acid, contributing to the establishment of a humid microenvironment that is characterized by potent antibacterial properties, thereby facilitating the process of wound healing [18,19]. Our hypothesis posited that wound healing would exhibit variations not only in response to PBM treatment but also in relation to the wound's location (oral vs. skin). ...
... A significant influence on the fiber orientation, fiber diameters, texture, morphology and surface geometry is exerted by many operating parameters, such as the surface tension, viscosity, and crystallinity of the electrospinning solution; the solvents used; the electrical conductivity and voltage; the temperature and humidity in the chamber; the distance between spinneret and collector; and the molecular weight of the polymer [22,23]. ...
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... Another study found that administering Nob intraperitoneal to OVX mice might restore their lost femurs, but oral PMF is sufficient to restore bone mass. [132] PMF inhibited the production of LPSinduced chemicals that cause inflammation, such as IL6, TNF, and PGE2. PMF does not affect the uterine weight of OVX mice, and oral PMF can help treat postmenopausal osteoporosis. ...
... The best advantage of the hairline approach is that the cosmetic outcomes are excellent, resulting in patients' emotional satisfaction. [44] Minimally invasive surgical techniques in the head and neck region have advanced steadily. ...
