Ana Olsavszky's research while affiliated with Universität Heidelberg and other places
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Publications (3)
Simple Summary
Deficiency and targeting of Stabilin-1, which is expressed by liver sinusoidal endothelial cells and subsets of macrophages, has been shown to improve anti-tumor immune responses in preclinical and early clinical studies. This study investigated whether targeting of Stab1 might also influence melanoma liver colonization, as hepatic m...
Background
Cutaneous melanoma exhibits heterogeneous metastatic patterns and prognosis. In this regard, liver metastasis, which is detected in ~ 10–20% of stage 4 patients, came to the fore of melanoma research, as it recently evolved as decisive indicator of treatment resistance to immune checkpoint inhibition.
Methods
Hepatic metastases were ind...
The Class H scavenger receptors Stabilin-1 (Stab1) and Stabilin-2 (Stab2) are two of the most highly expressed genes in liver sinusoidal endothelial cells (LSECs). While Stab1-deficient (Stab1KO) and Stab2-deficient (Stab2KO) mice are phenotypically unremarkable, Stab1/2-double-deficient (StabDKO) mice exhibit perisinusoidal liver fibrosis, glomeru...
Citations
... 4,5 Liver metastases, occurring in 10%−20% of cutaneous melanoma patients, present unique challenges, emphasizing the urgency for innovative treatment strategies. 6,7 Genetic analyses have identified frequent chromosomal loss at 9p13-p22 in melanoma, implicating Interleukin 11 receptor alpha (IL11RA) as a pivotal player encoded in this region. 8,9 IL11RA, situated in the IL-11/IL11RA signaling pathway, governs various biological processes, making it an attractive therapeutic target. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/805122653315073-1568967607262_Q64/Cyrill-Geraud.jpg)
... Also found in this series were STAB2, CLEC4G, and LYVE1 genes as midlobular zone 2 markers and confirmed as an expressed healthy human liver [6,7]. STAB2 is primarily expressed in LSECs and is clinically relevant [28,29]. Gene AQP1 (Aquaporin-1) promotes angiogenesis, fibrosis, and portal hypertension and is reported as overexpressed in endothelial cells in advanced fibrotic stages such as cirrhosis [30], which exhibits similar trends of overexpression in our dataset, illustrated in Supplementary Figure S1. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272749406978082-1442039934873_Q64/Carsten-Sticht.jpg)
