Ana Canto's research while affiliated with Instituto Nacional de Investigação Agrária e Veterinária (INIAV) and other places
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Publications (8)
Typical CRISPR (clustered, regularly interspaced, short palindromic repeat) regions are constituted by short direct repeats (DRs), interspersed with similarly sized non-repetitive spacers, derived from transmissible genetic elements, acquired when the cell is challenged with foreign DNA. The analysis of the structure, in number and nature, of CRISP...
Resistance to isoniazid, ethambutol, and streptomycin was detected in a Mycobacterium tuberculosis strain, belonging to the Beijing family lineage, isolated from two nodule exudates of a Yorkshire terrier with generalized
tuberculosis. This report alerts medical practitioners to the risk of dissemination of pre-multidrug-resistant tuberculosis
(pre...
Mycobacterium avium subsp. hominissuis (MAH) is an important opportunistic pathogen, infecting humans and animals, notably pigs. Several methods have been used to characterize MAH strains. RFLP and PFGE typing techniques have been used as standard methods but are technically demanding. In contrast, the analysis of VNTR loci is a simpler, affordable...
Bovine tuberculosis (bTB), widely considered a disease of livestock, can also affect large game species despite their poorly
understood role in the epidemiology of the endemic state of the disease. The Idanha-a-Nova County, situated in the eastern
region of central Portugal, is one of the most important regions for large game hunting activity. In o...
Mycobacterium bovis and, more rarely, Mycobacterium caprae, may cause zoonotic bovine tuberculosis (bTB) in an extensive range of animal species. In Portugal, during 2009, a remarkable raise of bTB incidence was registered in cattle along with an increase of new cases in wildlife. In this work, we reassess and update the molecular epidemiology of b...
Zoonotic bovine tuberculosis (bTB), caused by Mycobacterium bovis and, more rarely, by Mycobacterium caprae, is an important disease of livestock and of public health concern (1).
A low incidence of bTB has been observed until now in Portugal, where a comprehensive eradication scheme has been implemented. Epidemiological surveys carried out in seve...
Citations
... Early studies of the system structure and, mostly, the repeats and spacers of CRISPR loci assumed that the elements are suitable for genotyping mycobacterial strains in epidemiological research [83,84]. It was not until recently that the mechanism of function of the CRISPR/Cas system and the expression regulation of its components came to be studied in mycobacteria [85,86]. ...
Reference: Genetic Engineering in Mycobacteria
... A panel of eight MIRU-VNTR markers has been identified as a suitable tool to discriminate isolates and to study the genetic variability of the strains within the MAC. However, 7, 16, and 20 loci genotyping assays are also available Leao et al., 2014). ...
... In conclusion, the prospect of an elephant potentially acting as a carrier/reservoir for the transmission of drug-resistant M. tuberculosis as a result of human-animal interactions is a serious concern that may pose future risks not only to humans but also to TB control in livestock and wildlife (57). A One Health approach is fundamental to understanding the spillover or transmission dynamics of infectious diseases such as TB. ...
... In Portugal, red deer (Cervus elaphus) and wild boar (Sus scrofa) have been recognised as the most TB-relevant wildlife hosts, with reports of environmental contamination of natural substrates (soil and water bodies) in areas where wildlife TB is highly prevalent [46,47,48,49,50]. In this work, we aimed to increase global understanding of spatial-temporal indirect interaction patterns within a multi-host mammal community (cattle and wildlife: red deer, wild boar, red fox (Vulpes vulpes), and badger (Meles meles)), focusing on a high prevalence TB area within a Mediterranean agroforestry system of Southern Portugal. ...
... The main affected livestock species worldwide is Bos taurus (bovine), and in the Iberian Peninsula, the main affected wildlife species are Sus scrofa (wild boar) and Cervus elaphus (red deer) (2)(3)(4). The livestockwildlife interface is considered of key importance in the dissemination of M. bovis by both direct and indirect transmission routes, which are highly dependent on husbandry systems and host activity aggregation points (5)(6)(7)(8)(9)(10). ...
... It is based on three pillars: (i) detection and compulsory slaughter of animal reactors to the single intradermal comparative cervical tuberculin test, (ii) routine surveillance of carcasses at slaughterhouses, and (iii) pre-movement testing (11). The official wildlife surveillance program targets a hotspot risk area related to the synanthropy of big game species due to natural conditions and artificial management, in east-central and eastern-south mainland Portugal (5,6,(12)(13)(14). In this area, TB prevalence in cattle (herd level) was 0.5%-1.24% in the 2007-2017 period (11); in wild boar, it ranged from 15.9% down to 5.6% in the 2008-2016 period; and, in red deer, from 10.3% to 5.0% in the 2008-2016 period (5,15). ...