Alisha Geldert's research while affiliated with National University of Singapore and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (6)
There has been growing interest in the development of paper-based biosensors because their simplicity and low cost are attractive for point-of-care diagnosis, especially in low-resource areas. However, only a limited range of paper materials - primarily chromatography papers - have been incorporated into diagnostics thus far. Here, we investigate t...
Carbon nanomaterials are some of the most versatile nanomaterials. Along with increasing explorations into their utilization in a plethora of biological and biomedical applications, there have been emerging interests and needs in understanding the molecular hemocompatibility of these engineered nanomaterials when coming into contact with blood. Her...
Aptamer-based biosensing, which uses short, single-stranded nucleic acid segments to bind to a target, can be advantageous over antibody-based diagnostics due to the ease of synthesis and high stability of aptamers. However, the development of most aptamer-based sensors (aptasensors) is still in its initial stages and many factors affecting their p...
The novel application of two-dimensional (2D) single-layer ternary chalcogenide nanosheets as "capture-release" fluorescence-based biomolecular nanosensors is demonstrated. Fluorescently labeled biomolecular probe is first captured by the ultrathin Ta2 NiS5 nanosheets and then released upon adding analyte containing a target biomolecule due to the...
We demonstrate a highly selective and sensitive aptamer-based “capture-release” fluorescence detection of a malarial biomarker, i.e., Plasmodium lactose dehydrogenase (pLDH) protein, using single-layer two-dimensional MoS2 nanosheets. The detection of the target pLDH protein utilizing the aptamer-nanosheet sensing platform is rapid and can be easil...
Citations
... Organic molecules have been shown to modify the photoluminescence (PL) spectrum of a TMD 28,32 . An exciting proposal is to use a layer of molecular aptasensors on the TMD as a selective probe of biological and infectious compounds 33,34 , such as those involved in malaria 35 , cancer 36 and liver function 37 . In the absence of these compounds, energy transfer between the molecular layer and the neighbouring TMD quenches the signal of the aptasensor. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281127065303-1678915610300_Q64/Ct-Lim.jpg)
... Nanoparticles with a diameter of > 40 nm are comparable in size to large proteins and can form various complexes with them depending on the properties of the surface. Complexes may have different biokinetics, activity, and even functions [15,16]. If the particle does not disintegrate and its size exceeds 5 nm, the nanoparticle cannot be excreted through the kidneys and, thus, can cause more pronounced damaging effects in the body [17]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/304577377701888-1449628313094_Q64/Kian-Loh.jpg)
... 189 This makes FRET an extremely useful technique to study molecular interactions. 190 Li et al. 154 analyzed the interaction of GO with amino acids, peptides and proteins. A strong decrement in the fluorescence intensity of tryptophan on interaction with GO (after eliminating the inner filter effect) indicated adsorption of Trp or Tyr via π−π interaction or hydrophobic interaction on GO. ...
... This shows undeniable coupling among the 1-D chain structure via the angle-resolved high-resolution photoemission spectroscopy [24]. There are three sets of chain structures in Ta2NiS5, allowing considerable in-plane anisotropy of electrical and optical properties [25][26][27]. Moreover, the monolayer Ta2NiS5 has a 0.36 eV direct bandgap, and the bulk Ta2NiS5 exhibits a 0.39 eV direct bandgap [28], which shows that it has great potential in broadband applications. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/446637588914177-1483498107039_Q64/Zhuangchai-Lai.jpg)
... By using single-layer MoS2 nanosheets and a single-stranded aptamer probe labelled with the fluorescent dye, fluorescein, Kenry's group studied the fluorescence detection of Plasmodium lactose dehydrogenase protein, a highly expressed malarial biomarker. A heterogeneous mixture of proteins was used to test this sensing platform which was able to distinguish the target Plasmodium lactose dehydrogenase protein[403]. An aptamer-based sensor was also presented by Lv and co-workers for the detection of microcystin-LR, a representative toxin released by Cyanobacteria in water, using MoS2 and DNA coated UCNPs. ...
