Alina C Gonçalves's research while affiliated with Instituto Superior Técnico and other places
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Publications (2)
Accidental spills and misuse of pesticides may lead to current and/or legacy environmental contamination and may pose concerns regarding possible risks towards non-target microbes and higher eukaryotes in ecosystems. The present study was aimed at comparing transcriptomic responses to effects of sub-lethal levels of six environmentally relevant pes...
Alachlor has been a commonly applied herbicide and is a substance of ecotoxicological concern. The present study aims to identify molecular biomarkers in the eukaryotic model Saccharomyces cerevisiae that can be used to predict potential cytotoxic effects of alachlor, while providing new mechanistic clues with possible relevance for experimentally...
Citations
... Seuls quelques autres travaux ont rapporté des études basées sur la protéomique (Seo et al. 2013 ;Tiwari et al. 2018). C'est aussi le cas de certaines études basées sur la transcriptomique, menées pour évaluer l'impact de différents pesticides synthétiques sur diverses espèces et souches microbiennes (Dennis et al. 2003 ;Jang et al. 2008 ;Nde et al. 2008 ;Allen et Griffiths 2012 ;Lu et al. 2013 ;Li et al. 2015 ;Namouchi et al. 2016 ;Gil et al. 2018 ;Meng et al. 2019 ;Mesnage et al. 2020). ...
... In this context, the microbial model S. cerevisiae is a favorable experimental tool whose data can be, under certain circumstances, meaningful for other eukaryotes that may be exposed to environmental pollutants (discussed above). In the field of yeast-based environmental toxicogenomics, relevant data have accumulated enabling the disclosure of toxicity biomarkers, expression signatures and mechanistic pathways underlying the yeast response to the toxicological effects of pesticides Gil, Gonçalves, Becker, & Viegas, 2018;Gil, Gonçalves, Jacinto, Becker, & Viegas, 2011;Teixeira, Fernandes, Mira, Becker, & Sá-Correia, 2006) and other environmental contaminants (Caba, Dickinson, Warnes, & Aubrecht, 2005;Cusik, Boyer, Wilhelm, & Sayler, 2009), just to refer some examples among the large number of studies reported in the last two decades (reviewed in Yasokawa & Iwahashi, 2010;dos Santos et al., 2012;Braconi et al., 2016). ...