Alfonso Cardozo's research while affiliated with Central University of Venezuela and other places
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Publications (13)
![Fig. 5 Norpurpureine inhibits agonist-induced elevation of [Ca 2+ ] i...](profile/Claudia-Alvarado-Castillo/publication/324596452/figure/fig2/AS:616963147571200@1524106885684/Norpurpureine-inhibits-agonist-induced-elevation-of-Ca-2-i-in-human-platelets-a_Q320.jpg)
Background: The leaves of Annona purpurea have yielded several alkaloids with anti-aggregation activities against rabbit platelets. This is promising in the search for agents that might act against platelets and reduce the incidence of cardiovascular diseases. Since significant differences in platelet function have been reported between human and a...
The Aspidosperma genus (Apocynaceae) represents one of the largest sources of indole alkaloids widely associated with cardiovascular effects. Aspidosperma fendleri, a plant found mainly in Venezuela, has a single phytochemical report in which is revealed the presence of alkaloids in its seeds. This study explored the cardiovascular effects of an et...
Three new lupane-type triterpenoids: 6β,30-dihydroxybetulinic acid glucopyranosyl ester (4), 6β,30-dihydroxybetulinic acid (5) and 6β-hydroxybetulinic acid (6), were isolated from Licania cruegeriana Urb. along with six known compounds. Their structures were elucidated on the basis of spectroscopic methods, including IR, ESIMS, 1D- and 2D-NMR exper...
Highlights
► Twelve compounds were isolated from C. venezuelanus. ► This work constitute the first phytochemical report for C. venezuelanus. ► Chemical profile identified in this specie was similar to that of C. icaco. ► This work suggests a chemosystematic relationship between Licania and Chrysobalanus.
Pomolic acid has recently shown hypotensive effect in rats. The purpose of this investigation was to determine the vascular effects of this triterpenoid and to examine its mode of action. Functional experiments in rat aortic rings precontracted with norepinephrine were performed to evaluate the vasorelaxant effect of pomolic acid. This triterpenoid...
Most of the arborescent Croton species in the New World were treated by Webster as belonging either to C. sect. Cyclostigma Griseb. or C. sect. Luntia (Neck. ex Raf.) G.L. Webster. The circumscription of C. sect. Cyclostigma has been treated recently. In this paper we focus on C. sect. Luntia, which was subdivided by Webster into two subsections, C...
Most of the arborescent Croton species in the New World were treated by Webster as belonging either to C. sect. Cyclostigma Griseb. or C. sect. Luntia (Neck. ex Raf.) G.L. Webster. The circumscription of C. sect. Cyclostigma has been treated recently. In this paper we focus on C. sect. Luntia, which was subdivided by Webster into two subsections, C...
Several Chrysobalanaceae family members are considered medicinal plants in South America and their infusions have been widely used to treat several diseases, such as diabetes and hypertension. Methanolic extract from the leaves of Licania pittieri (Chrysobalanaceae), has previously shown hypotensive effect in anaesthetized normotensive rats. The ai...
Citations
... The genus Croton (Euphorbiaceae family), with approximately 1300 species of herbs, shrubs, and trees, is one of the largest genera of flowering plants and is mainly distributed in both tropical and subtropical regions of Africa, America, and Asia (Berry et al., 2005;Riina et al., 2010). Croton sylvaticus Hochst. ...
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... Dentro del grupo de sustancias bioactivas extraídas de esta especie se encuentran los alcaloides. Uno de ellos, la norpurpureina mostró un perfil farmacológico in vitro prometedor como inhibidor de la activación plaquetaria humana, lo que resulta importante ya que los agentes que actúan contra la agregación plaquetaria pueden reducir la incidencia de enfermedades cardiovasculares (Sánchez et al., 2018). Otros alcaloides de anonna chincuya han mostrado también efectos positivos sobre enfermedades inflamatorias (Chávez y Mata, 1998) y efectos ansiolíticos (Rejón-Orantes et al., 2011). ...
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... Many of this species are used in folk medicine for the treatment of malaria [8], fever [9], inflammation, diabetes, high blood pressure [10], and cardiovascular diseases [11]. In addition, studies carried out with extracts from several species of Aspidosperma showed important antihypertensive effects [12][13][14][15]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272192726368261-1441907211746_Q64/Margarita-Salazar.jpg)
... Reserpine, an antihypertensive agent that is no longer used, is extracted from the roots of Rauwol a serpentine; and verapamil, a papaverine derivative (Zhao et al. 2020) with antiarrhythmic and antihypertensive properties, is now available for commercial use. 6β-Hydroxybetulinic acid (6HB), see Fig. 1, is a triterpenoid isolated from the Licania cruegeriana, which demonstrated a hypotensive effect in hypertensive rats and also an antiaggregant effect in human platelets (Estrada et al. 2014). In order to demonstrate that 6HB has a direct effect on smooth muscle contraction that could explain its effect on blood pressure, we decided to evaluate its vasorelaxing effect on isolated rat aortic rings. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/746845567451136-1555073267167_Q64/Whendy-Contreras-2.jpg)
... According to the literature, it appears that sumaresinolic and siaresinolic acids are not restricted to the Styrax genus but also occur in the aerial parts of plant species from other genera (e.g., [61][62][63][64][65][66]). Nonetheless, none of these plants produce resinous exudates containing ester derivatives of cinnamic and benzoic acids. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/797358342299648-1567116451027_Q64/Dumas-Conde.jpg)
... Leucosidea sericea Rosaceae Aerial part (Estrada et al., 2009(Estrada et al., , 2011 19 ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/278851331608580-1443494746217_Q64/Mercedes-Lopez-3.jpg)
... The species in the Riau pocket group (group I 4 in Fig. 1) comprise rheophytic species. Riina et al. (2010) mentioned that rheophytic species in the neotropics have seeds with arils and are likely dispersed by fish eating the arils. However, the Sumatran species lack arils and the seeds have very small caruncles and are likely not dispersed by fish. ...
... Leucosidea sericea Rosaceae Aerial part (Estrada et al., 2009(Estrada et al., , 2011 19 ...
