Ajay Sharma's research while affiliated with Delhi Institute of Pharmaceutical Sciences and Research and other places
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Publications (5)
Rheumatoid arthritis is a hyperactive immune disorder that results in severe inflammation in synovial joints, cartilage, and bone deterioration, resulting in immobilization of joints. Traditional approaches for the treatment of rheumatoid arthritis are associated with some limiting factors such as suboptimal patient compliance, inability to control...
Nanotechnology has revolutionized cancer diagnosis and therapy through targeted drug delivery. Advances in protein engineering and materials science have led to the development of nanocarriers (NCs), which have helped overcome the challenges faced during conventional cancer treatment. These nanocarriers serve as an efficient transport module for dr...
Cancer is one of the deadliest diseases associated with high mortality, and treatment options are limited and conventional drug used in treatment of cancer face various challenges like poor solubility and lower circulation period in plasma and these challenges are addressed by nanocarriers aid in improving the pharmacological action-based efficacy...
Rapid advancements in the field of anticancer vaccination paved the way for recognizing several targets to stimulate an immune response against one or multiple tumor-associated antigens (TAAs). Tumor-specific immune activation is specifically dependent upon a tumor-reactive T-lymphocyte response. Peptide-based vaccines targeting T-cells are one of...
Citations
... In affluent countries, the prevalence of this illness among adults (which affects women more than men) varies between 0.5 and 1% during their working life IL-6, IL-1, MMPs and TNF-α may cause the synovial lining to thicken and fibroblast-like synoviocytes to increase, leading to synovitis. RA therapy options have proven to be effective; however, research now focuses on creating cutting-edge medicines to surpass the adverse effects of dose escalation-induced defunctionalization and therapeutic tolerance [2]. Due to their poorly soluble nature, large dosages, increased toxic nature, shorter halflives and unspecific administration routes, conventional therapeutics have a limited range of applications. ...