Abdulmajeed F. Alrefaei's research works | Umm Al-Qura University, Mecca and other places

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New thiazol-pyridazine derivatives as antimicrobial and antiviral candidates: Synthesis, and application

Article

Mar 2024

Harnessing Oleanolic Acid and Its Derivatives as Modulators of Metabolic Nuclear Receptors

Article

Full-text available

Sep 2023

Nuclear receptors (NRs) constitute a superfamily of ligand-activated transcription factors with a paramount role in ubiquitous physiological functions such as metabolism, growth, and reproduction. Owing to their physiological role and druggability, NRs are deemed attractive and valid targets for medicinal chemists. Pentacyclic triterpenes (PTs) rep...

Harnessing Oleanolic Acid as A Modulator of Metabolic Nuclear Receptors

Preprint

Full-text available

Sep 2023

Efficient Removal of Deltamethrin from Aqueous Solutions Using a Novel Lanthanum Metal–Organic Framework: Adsorption Models and Optimization via Box–Behnken Design

Article

Full-text available

Aug 2023

Eliminating pesticides is essential for lowering the dangers to our environment. To do this effectively, it is crucial to find adsorbents with remarkable adsorption capacities, easy retrieval, and separation. Metal-organic frameworks (MOFs) have been extensively recognized for their exceptional ability to absorb pollutants. Therefore, we used novel...

Fig. 1 Cytotoxicity effect of Prunus armenica on human pancreatic...

IC 50 values of PANC-1 and A549 cell lines incubated with Prunus...

Efficacy of Prunus armenica, Bee venom, and their combinations on p53 and Bcl-2 gene expression in human pancreatic and lung cancer cells

Article

Full-text available

Jul 2023

Malignancies are one of the world’s most serious health problems. Pancreatic and lung cancers are two of the most lethal types of cancer, with 5-year survival rates ranging from 10 to 20%. Despite decades of investigation, the molecular processes and selectivity of Prunus armenica and Bee venom as anticancer drugs are still largely un-understood. T...

Synthesis, modeling, and biological studies of new thiazole-pyrazole analogues as anticancer agents

Article

Jun 2023

A series of various substituted thiazole-pyrazole hybrids 5, 7, 8, and 9 were synthesized, and their chemical structures were confirmed by spectral data (infrared, 1H & 13C NMR and Mass). The frontier molecular orbital structural and energetic properties of the targeting thiazole-pyrazole hybrids were explored using the DFT/B3LYP methodology. The d...

Figure 1. Available methods for plant disease detection: (A,B) direct...

Figure 2. Advantages and challenges/disadvantages of using drones for...

Use of drones and other devices for plant disease detection.

Drones in Plant Disease Assessment, Efficient Monitoring, and Detection: A Way Forward to Smart Agriculture

Article

Full-text available

May 2023

Plant diseases are one of the major threats to global food production. Efficient monitoring and detection of plant pathogens are instrumental in restricting and effectively managing the spread of the disease and reducing the cost of pesticides. Traditional, molecular, and serological methods that are widely used for plant disease detection are ofte...