Aaron P Petty's research while affiliated with Washington State University and other places
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Publications (3)
Expression of Migration inducting gene-7 (Mig-7) is limited to tumor cells and to date not found in normal tissues. Multiple tumor microenvironment factors, such as epidermal and hepatocyte growth factors, in concert with alphavbeta5 integrin ligation, induce Mig-7 mRNA expression. Gain or loss of Mig-7 protein studies shows that Mig-7 promotes inv...
Gain or loss of Migration inducting gene-7 (Mig-7) protein expression functional studies suggest it causes aggressive tumor cell invasion and tumor cell vessel-like structure formation. In addition, Mig-7 expression is apparently carcinoma and trophoblast cell-specific. Mig-7 is an example of an atypical gene that is unique in its induction, transl...
Molecular requirements for carcinoma cell interactions with the microenvironment are critical for disease progression but are poorly understood. Integrin alpha v beta 5, which senses the extracellular matrix, is important for carcinoma cell dissemination in vivo. alpha v beta 5 signaling induces Mig-7, a novel human gene product that is apparently...
Citations
... Our previous work showed that P. polyphylla ethanol extract suppresses VM and tumor growth in OS. 21 We also found that it could decrease the expression of migration-inducing gene 7 (MIG-7), a key molecular in various tumor VM formation including OS. 22,23 Another study showed that MIG-7 is the upstream regulator of PI3K/AKT pathway, 24 which is a hyper-activated pathway in regulating VM formation by increasing MMPs and the consequent cleavage of Laminin-5g2 (Ln-5g2). 25 Besides, actin-based cell protrusions are involved in VM and some VM-disrupting drugs exert their effects through damaging cytoskeletal integrity. ...
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... Trophoblast and tumor cells will also emulate epithelial cells to achieve angiogenesis. Migration-inducing gene 7 (MIG-7) enables trophoblasts and tumor cells to invade, as it is present in most epithelial-emulating tumor cells and invasive extravillous trophoblasts (EVTs) [19]. Matrix glycoprotein-binding galectin 3 is overexpressed in EVTs and helps aggressive melanomas to develop an endothelial phenotype [20]. ...
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... However, this may be a problem of the translation algorithm that is formulated based on the current concept of gene. Indeed, today's algorithm cannot translate some human mitochondrial RNAs [78] and cannot explain why some RNAs with multiple stop codons, such as the Mig-7 mRNA [79][80][81], can still be expressed to a protein. The current algorithm cannot translate the mRNAs containing the CAG and GGGGCC repeats either [82][83][84]. ...
