A.J. Brown's research while affiliated with The University of Sydney and other places
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Publications (9)
To investigate the effects of practical amounts of n-3 highly-unsaturated fatty acids (HUFA) on a number of parameters involved in haemostasis, 12 healthy men were fed three diets in a 3 x 3 cross-over design. The diets, fed as the evening meal for 6-week periods, were: Control diet (essentially fish-free), Fish diet (200 g/d of lean Australian fis...
The fatty acid composition of erythrocyte membranes was investigated in 21 healthy men after 6 wk of varying intakes of eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3). In one experiment, 12 subjects were fed three diets in a 3 x 3 crossover design: an essentially fish-free control diet, a fish diet (0.15 g EPA/d, 0.41...
To determine if apolipoprotein (apo) E polymorphism influences postprandial lipemia and hence can help explain the wide range of lipemic responses to a standardized fat meal observed previously, blood samples were collected from 25 healthy men whose postprandial responses to a standardized fat meal had been measured. Venous blood samples had been o...
To examine the incorporation of n-3 polyunsaturated fatty acids (PUFAs) into erythrocyte membranes during and after moderate n-3 PUFA intake, 12 healthy men were fed three diets for 6-wk periods in a 3 x 3 crossover design, supplying different amounts of eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3): a control diet, a...
To test the hypothesis that conditioning with a practical dose of fish oil will reduce postprandial lipemia, 25 healthy men were matched according to levels of fasting plasma triacylglyceride and allocated to 6 weeks of either fish oil or olive oil supplements (5 g/day). After a 12-hour overnight fast at the termination of the study period, the sub...
Twelve healthy men were fed in turn three diets for 6 wk each in a 3 x 3 randomized block design: a control diet (essentially fish free), a fish diet (200 g lean Australian fish flesh/d), and the same fish-based meal but supplemented with 5 g fish oil/d. Dietary eicosapentaenoic acid [EPA, 20: 5n-3 (omega-3)] was strongly associated with erythrocyt...
Presented are the lipid content and fatty acid composition of 20 species of edible AustralianAcacia seeds. Aborigines reportedly have used at least 18 of these as foods. Seed lipid content ranged from 3% to 22%, with an average
of 11% on a dry weight basis. Linoleic (12–71%), oleic (12–56%) and plamitic (7–35%) acids were the major fatty acids. Sma...
Citations
... The fatty acid composition of fish muscle depends on food and feeding habit. For example, algae and phytoplankton-eating fishes (herbivores) are rich in both LA and ALA (Henderson and Tocher 1987;Brown et al. 1989). In contrast, zooplankton and prey fish-eating fishes are rich in n-3 LC PUFAs but poor in LA and AA (Brown et al. 1989). ...
... Found in a range of different terrains across the continent, seeds were often eaten raw, steamed, or roasted. When roasted, they were often ground using specific tools into a coarse meal, then either stirred into a paste using water and consumed as is or baked on hot coals into a simple damper (Adewusi et al., 2003;Brand et al., 1998;Brown et al., 1987;Harwood, 1994;Latz, 2018;Maslinet et al., 1998;Mc Donald et al., 2002). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/278719580131330-1443463334143_Q64/Vic-Cherikoff.jpg)
... One caveat is that the platelet count of healthy humans on fish oil supplementation is mildly but significantly decreased. [37][38][39] This could suggest that increased ω-3 PUFAs lead to increased clearance, e.g., by increased sequestration due to increased membrane fluidity. Therefore, the functional increase could come at the expense of mildly reduced platelet survival. ...
... Japanese cedar and cypress trees shed their pollen between February and April. Because PUFAs take 4-8 weeks after ingestion to be incorporated into the biomembrane [43,44], the intake of DGLA commenced approximately 8 weeks before the peak of pollen dispersal in March, starting on 8 January 2022. DGLA intake was continued until 23 April 2022, when pollen dispersal had mostly ceased, for a total of 15 weeks. ...
... A recent study provided evidence that fish oil supplementation increases EPA levels more than DHA, potentially due to differing rates of incorporation rates into membrane phospholipids. While EPA supplementation increases levels in plasma and erythrocytes, it does not affect plasma triacylglycerols [42]. These differences in incorporation rates are also observed in adipose tissue [43]. ...
... However, not all the studies have found an association between the 4 allele and increased postprandial serum triglyceride concentrations. For instance studies by Brown and Roberts (1991) and Bergeron and Havel (1996) demonstrated a delayed response while Boerwinkel, Brown, Sharret, Heiss & Patsch (1994) Most studies that reported a significant effect of the 4 allele on postprandial triglyceride concentrations used participants that were mostly at advanced age or that were having one or more metabolic disorders (Reznik, Pousse, Herrou, Morello & Mahoudeau et al., 1996;Dart et al., 1997). The effect of 4 allele on postprandial triglyceride levels among young adults with no evident metabolic disorder has not been extensively assessed. ...
... There is also well-described evidence that long-term supplementation with fish oil lowers fasting and postprandial TG in metabolically healthy, normolipidemic subjects. Brown and Roberts (46) reported that, in comparison to olive oil, 6 wk of fish oil intake led to a significantly lower postprandial TG concentration in response to a standardized high-fat meal. Park and Harris (47) confirmed this observation by showing that supplementation with marine n-3 FAs for 4 wk reduced postprandial TG concentration by 16%. ...
... [19][20] Also, participant ages ranged widely, with mean ages between 20 and 73 years (Tables 3 6,8,9,20,28,29,33,47-52 and 4). 19,26,27,[53][54][55][56][57][58][59][60] Of the 24 RCTs, 13 used a parallel design and 11 studies used a crossover design. Of RCTs with a parallel design, the number of participants ranged from 10 to 72 per group, and the ratio of male participants to female participants was approximately 50%:50%. ...
... The total daily amount of mercury intake is known to be strongly related to the amount of fish consumption [12, 13]. The fish consumption, which was measured directly or by using food frequency questionnaires, was related to EPA concentrations in RBC141516. In the present study, RBC Hg concentrations were related to fish consumption among women but not among men. ...
