A Seeger's research while affiliated with University of Tuebingen and other places

Publications (104)

Article
Objective: This study aimed to analyze the possibility of artifact reduction using a new iterative metal artifact reduction algorithm (iMAR) in the diagnosis of perfusion deficits due to vasospasms and to evaluate its clinical relevance. Methods: Sixty-one volume perfusion computed tomographies of 24 patients after coiling or aneurysm clipping w...
Article
Full-text available
Background and purpose: Patients with Moyamoya Disease (MMD) need hemodynamic evaluation of vascular territories at risk of stroke. Today's investigative standards include H215O PET/CT with pharmacological challenges with acetazolamide (ACZ). Recent developments suggest that CO2-triggered blood‑oxygen-level-dependent (BOLD) functional MRI might pr...
Article
Background Diffusion-weighted imaging (DWI) has become an important tool for lesion characterization. Advanced techniques of DWI may be used to improve image quality. Purpose To evaluate multi-shot segmented DWI (rs-EPI, RESOLVE) and reduced field-of view DWI (rFOV-EPI, “zoomed” EPI) in patients with ocular melanoma and to compare image quality an...
Article
Objective The objective of this article is to evaluate advanced techniques of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurements of the optic nerve in patients with optic neuritis. Methods In this prospective and institutional review board-approved trial, we examined 15 patients with acute visual loss and clinic...
Article
Objective Ischemic mitral regurgitation is a predictor of heart failure resulting in increased mortality in patients with chronic myocardial infarction. It is uncertain whether the presence of papillary muscle (PM) infarction contributes to the development of mitral regurgitation in patients with chronic myocardial infarction (MI). The aim of the p...
Article
Aim: To compare image quality and evaluate its clinical importance in common temporal bone pathologies of a pTX-SPACE (parallel transmit [pTX] three-dimensional turbo spin-echo with variable flip angle [SPACE]) magnetic resonance imaging (MRI) sequence improved for spatial resolution to a standard-SPACE sequence exhibiting the same scan time at 3...
Article
Full-text available
Flow diverters (FDs) are designed for the endovascular treatment of complex intracranial aneurysm configurations. From February 2009 to March 2013 28 patients (22 females, 6 males) were treated with FD; mean age was 57 years. Data, including aneurysm features, clinical presentation, history of previous bleeding, treatment, and follow-up results, ar...
Article
Rationale and objectives: The purpose of this study was to compare a standard T2 SPACE sequence (standard-SPACE) used in temporal bone imaging at 3 T with a new parallel-transmit-accelerated 2D-selective radio frequency excitation technique for SPACE which was either time-improved or resolution-improved. Materials and methods: Thirty-two consecu...
Data
Full-text available
Supplementary Table 1: The table shows patients' characteristics of all 28 patients including age, sex, clinical symptoms, aneurysm size and location, special findings, treatment effect, and clinical outcome in the follow-up period.
Article
Fortunately, polytrauma is a rare condition in children. However, accidents are the leading cause of death in children and adolescents. Due to different anatomic proportions as well as smaller vital reserves, there are specific characteristics in childhood, requiring knowledge of typical injury patterns. Because of the low incidence, immediate mana...
Article
Newborns and small infants have shallow breathing. To suggest criteria for when respiratory gating is necessary during cardiac MRI in newborns and infants. One-hundred ten data sets of newborns and infants with (n = 92, mean age: 1.9 ± 1.7 [SD] years) and without (n = 18, mean age: 1.6 ± 1.8 [SD] years) navigator gating were analysed retrospectivel...
Article
To prospectively compare the image quality and diagnostic performance of orbital MR images obtained by using a dual-source parallel transmission (pTX) 3D sequence (Sampling Perfection with Application optimized Contrasts using different flip angle Evolution, SPACE) with the image quality of conventional high-resolution standard protocol for clinica...
Article
Magnetic resonance (MR) imaging (MRI) provides information that can be used to estimate the symptom onset in patients with wake-up stroke (WUS). Time-resolved MR angiography (MRA) is the fastest available MR sequence technique for vessel assessment, and the different phases acquired can provide information about cerebral perfusion. The aim of this...
Article
Fortunately polytrauma is a rare condition in children. However, accidents are the leading cause of death in children and adolescents. Due to different anatomic proportions as well as smaller vital reserves there are specific characteristics in childhood, requiring knowledge of typical injury patterns. Because of the low incidence immediate managem...
Article
Purpose: A new method for diffusion-weighted imaging (DWI) using independent parallel transmission technique resulting in zoomed DWI was applied in four patients suffering from acute spinal cord ischemia. Methods: Four patients with clinical symptoms of acute spinal cord ischemia were examined on a 3 T MR-system equipped with a two-channel trans...
Chapter
For a meaningful application of whole-body MRI in the clinical setting, it is necessary to have flexible imaging protocols. The use of protocols that can be modified to address an individual patient’s clinical situation enables us to image the entire body with the highest quality and in the shortest time possible.
Article
The evaluation of carotid-cavernous fistulas (CCFs) and the intracranial vasculature has been predominantly carried out using conventional digital subtraction angiography (DSA). Recent developments in time-resolved magnetic resonance angiography (MRA) provide the opportunity to assess both multiple arterial and venous phases with high temporal and...
Article
Three-vessel coronary artery disease (CAD) comes along with globally reduced myocardial perfusion potentially restricting the demarcation of regional hypoperfusion in stress perfusion cardiac magnetic resonance imaging (MRI). To evaluate whether stress perfusion cardiac MRI is capable of detecting myocardial hypoperfusion in patients with 3-vessel...
Conference Paper
PURPOSE The MitraClip System (Abbott Vascular) is a novel percutaneous interventional method for mitral valve repair. It is predominantly applied on patients that are not eligible for surgical valve repair. The purpose of this study was to examine reverse remodelling by evaluating pre- and postinterventional cardiac function and atrial dilatation....
Article
Magnetic resonance (MR) perfusion techniques and MR spectroscopy (MRS) provide specific physiological information that may allow distinction between recurrent glioma and progression from stable disease. Forty patients underwent conventional MR imaging, dynamic contrast-enhanced T1-weighted perfusion imaging, dynamic susceptibility contrast-enhanced...
Article
Full-text available
Rationale and Objectives: Long-term physical training is associated with morphological and functional adaptations of the cardiovascular system. Aim of this prospective study was to assess physiologic adaptations and structural cardiac remodelling and to analyze the presence and distribution of myocardial Late Gadolinium Enhancement (LGE) by cardiac...
Article
Purpose: Sudden cardiac death [SCD] in competitive athletes is caused by a diverse set of cardiovascular diseases such as hypertrophic and dilated cardiomyopathy [HCM/DCM], myocarditis, coronary anomalies or even coronary artery disease. In order to identify potential risk factors responsible for SCD, elite athletes underwent cardiac magnetic reso...
Article
Aim of our study was to evaluate, whether myocardial ischemia or myocardial infarction (MI) depicted by myocardial stress perfusion MR imaging (SP CMR) can predict the clinical outcome in patients with coronary artery disease (CAD). 220 patients were included. Myocardial perfusion was assessed at stress and at rest, using a 2D saturation recovery g...
Conference Paper
Ziele: Die kardiale MR-Bildgebung mittels Stressperfusion und late Enhancement ist ein etabliertes Verfahren zum Nachweis von Ischämie bzw. Myokardinfarkt bei koronarer Herzerkrankung (KHK). Es wurde der Zusammenhang zwischen Ischämie- bzw. Infarktnachweis und Auftreten erneuter kardialer Ereignisse (AE) untersucht. Ziel unserer Studie ist, ob der...
Article
Detailed knowledge of the venous mesenteric system is important for gastrointestinal surgery, particularly for transplantation planning and surgery and for the comprehension of perioperative complications that may influence patient outcome. Data about the mesenteric venous anatomy in the literature varies substantially. The purpose of this study wa...
Conference Paper
PURPOSE Long-term physical training is associated with morphological and functional adaptations of the cardiovascular system. The specific effect of handball training on cardiac morphology and function has not been investigated in female athletes by cardiac magnetic resonance imaging (MRI). METHOD AND MATERIALS Thirteen female professional handbal...
Article
To evaluate the feasibility and diagnostic impact of time-resolved MR angiography (TR-MRA) combined with parallel imaging and low contrast dose for the assessment of peripheral high-flow vascular malformations (VM) at 1.5 Tesla (T). Twelve consecutive patients (7 female, 5 male, mean age 24.7 ± 11.1 years) with known or suspected high-flow VM under...
Article
To assess the feasibility of a comprehensive MRI protocol using intrabiliary contrast medium (gadolinium-EOB-DTPA) for evaluation of living liver donors. In this prospective study, 30 donor candidates for living-related liver transplantation (17 men; 13 women, mean age 37 ± 10.9 years) underwent MRI including MR-angiography (MRA) as well as a conve...
Conference Paper
Full-text available
This work presents an automatic and robust approach to detect the heart region in MRI perfusion images. Intensity variance is used to identify high variability regions, which are in turn filtered with features based on their shape and position. The approach is validated using 44 clinical data sets against a ground truth generated by experts.
Article
The objective of our study was to assess the feasibility and diagnostic performance of time-resolved MR angiography (MRA) in the pretreatment evaluation of peripheral vascular malformations at 1.5 T. Twenty-two consecutive patients (15 women and seven men; mean age, 22.1 ± 12.1 years) who were known or suspected to have vascular malformations were...
Article
To investigate the feasibility of image fusion of MR-coronary angiography (MRCA) and delayed gadolinium enhancement imaging (LGE) and to assign areas of myocardial infarction to the corresponding supplying coronary arteries. An interactive segmentation of the coronary arteries was performed in MRCA data sets (n=25). The LGE slices were matched onto...
Conference Paper
PURPOSE High-level athletic training is associated with increased ventricular chamber sizes and myocardial mass [MM]. This physiologic form of hypertrophy, or athlete’s heart, is regarded as a benign adaptation to systematic athletic training with no adverse cardiovascular consequences. Therefore, purpose of this study was to determine ventricular...
Article
Restrictive right ventricular (RV) physiology is a phenomenon considered potentially beneficial when detected in children and adolescents with repaired tetralogy of Fallot (ToF). It is typically characterised by antegrade flow in the pulmonary artery in late diastole at the time of atrial contraction. However, little is known about the impact of re...
Conference Paper
Full-text available
The condition of the heart muscle tissue can be inferred by analyzing the time-intensity curves obtained with myocardial perfusion MRI. Specifically, identifying tissue that is under-supplied with blood is important when choosing a suitable therapy for patients with coronary heart disease. Before an analysis can be carried out, the images must be r...
Article
Ziele: Eine genaue Klassifizierung von peripheren Gefasmalformationen ist unabdingbare Voraussetzung im Rahmen der interdisziplinaren Therapieplanung. Ziel der Studie war die Evaluation des diagnostischen Stellenwertes einer neuen, zeitlich und ortlich hochaufgelosten MR Angiographie (MRA) Sequenz bei Patienten mit peripheren Gefasmalformationen. M...
Article
The aims of this study were to evaluate the effectiveness of low-dose, contrast-enhanced (CE), time-resolved, three-dimensional magnetic resonance angiography (MRA) in the assessment of the abdominal aorta and its major branches at 3 T and to compare the results with those of high-spatial resolution CE MRA. Twenty-two consecutive patients (eight me...
Article
The long-term prospects for patients with peripheral-arterial-occlusive disease (PAOD) must be considered in the context of coexistent generalized atherosclerosis. We sought to determine the added clinical information of noninvasive magnetic resonance imaging (MRI) for detecting asymptomatic atherosclerotic disease in patients already at high risk....
Article
Patients with congenital heart disease frequently have complex cardiac and vascular malformations requiring detailed non-invasive diagnostic evaluation including functional parameters. To evaluate the morphological and functional information provided by a novel 3-D cine steady-state free-precession (SSFP) sequence. Twenty consecutive children (mean...
Article
Stress perfusion magnetic resonance imaging (MSPMRI) is an established technique for the assessment of myocardial perfusion. Shortcomings at 1.5 T are low signal to noise ratio (SNR) and contrast to noise ratio (CNR). One approach to overcome these shortcomings is to increase field strength and contrast concentration. The aim of our study was to in...
Article
To longitudinally assess the value of cardiac functional and viability imaging as a supplement to MR angiography in patients with atherosclerotic disease. Cardiac MRI was performed in 195 consecutive patients with symptomatic peripheral arterial disease. Of these, 186 patients were followed for 22 +/- 5 months for the presence of cardiac events (ca...
Article
The purpose of this study was to determine the role of adenosine stress cardiac magnetic resonance (CMR) for risk stratification in patients with coronary artery stenoses of intermediate angiographic severity. Coronary angiography only provides a morphological description of coronary lesions. As the patient's prognosis is closely related to the fun...
Article
Ziele: Die Bestimmung der Ejektionsfraktion (EF) sowie Vitalitatsdiagnostik im MRT (delayed enhancement, DE) sind als prognostische Marker nach Myokardinfarkt etabliert. Ziel der Studie war die longitudinale Untersuchung des Stellenwertes von EF und DE in einem vaskularen Risikokollektiv mit oder ohne Infarktanamnese. Methode: Ein kardiales MRT wur...
Article
A 60-year-old woman presented to the emergency department with acute onset of severe chest pain. The pain started that morning, after witnessing the sudden cardiac death of a coworker. The electrocardiogram did not reveal evidence of ischemic ST segment deviations. Creatinine kinase was within the normal range but cardiac troponin T was elevated (2...
Article
Full-text available
Previous experiences of whole body MR angiography are predominantly available in linear 0.5 M gadolinium-containing contrast agents. The aim of this study was to compare image quality on a four-point scale (range 1-4) and diagnostic accuracy of a 1.0 M macrocyclic contrast agent (gadobutrol, n = 80 patients) with a 0.5 M linear contrast agent (gado...
Article
Full-text available
For contrast-enhanced imaging techniques relying on strong T1 weighting, 3 T provides increased contrast compared with 1.5 T. The aim of our study was the intraindividual comparison of delayed enhancement MR imaging at 1.5 T and at 3 T. Twenty patients with myocardial infarction were examined at 1.5 T and 3 T. Fifteen minutes after injection of con...
Article
Cardiac MRI is known to be diagnostically valuable in cardiac amyloidosis. Several features are frequently found, including myocardial hypertrophy, diastolic dysfunction, a faster gadolinium blood wash out, pleural and pericardial effusions, and diffuse myocardial delayed enhancement. Cardiac MR facilitates the detection of cardiac amyloidosis and...
Article
Full-text available
The study was approved by the local ethics committee, and informed consent was provided by all participants prior to the examination. The aim of the study was to assess the feasibility of whole-body three-dimensional (3D) contrast material-enhanced magnetic resonance (MR) angiography with parallel imaging in the phase- and section-encoding directio...
Article
Full-text available
Current magnetic resonance imaging (MRI) technology allows the determination of patient-individual coronary tree structure, detection of infarctions, and assessment of myocardial perfusion. Joint inspection of these three aspects yields valuable information for therapy planning, e.g., through classification of myocardium into healthy tissue, region...
Conference Paper
PURPOSE Myocardial perfusion magnetic resonance imaging (MPMRI) is used for the evaluation of coronary artery stenoses in patients with coronary artery disease. One option to compensate for shortcomings of MPMRI at conventional 1.5T systems including limited signal intensity and image contrast is to increase field strength. Aim of our study was the...
Article
This prospective study was designed to determine the diagnostic value of adenosine stress cardiac magnetic resonance imaging (CMRI) in patients referred to elective coronary angiography. Myocardial perfusion measurements at rest and adenosine stress were performed in 141 patients (105 men, 36 women, mean age 63.4 years) at 1.5 T with a Turbo Flash...
Article
Full-text available
The quality of magnetic resonance (MR) angiography could be substantially improved over the past several years based on the introduction and application of parallel imaging, new sequence techniques, such as, e.g., centric k-space trajectories, dedicated contrast agents, and clinical high-field scanners. All of these techniques have played an import...
Article
The aim of the study was to assess the feasibility and additional diagnostic information of cardiac MRI as a supplement to state-of-the-art MR angiography (MRA) in the case of vascular risk patients. Therefore, the prevalence of delayed myocardial enhancement (DE) was determined in patients suffering from peripheral artery disease (PAD) and a clini...
Article
The purpose of this study was to prospectively evaluate the diagnostic performance of contrast material-enhanced magnetic resonance (MR) angiography performed at 3 T for assessment of renal artery stenosis (RAS) by using parallel acquisition techniques with high acceleration factors and with digital subtraction angiography (DSA) as the reference st...
Article
To compare left ventricular (LV) volume and mass assessment using two-dimensional (2D) cine steady-state free precession (SSFP) and k-t space broad-use linear acquisition speed-up technique (k-t BLAST) accelerated 3D magnetic resonance imaging (MRI). On a commercially available 1.5T MR scanner, 2D cine SSFP, six- and eight-fold accelerated 3D k-t B...
Article
Ziele: Die Koronararteriendarstellung (MRCA) ist ein seit mehreren Jahren bekanntes Verfahren in der Magnetresonanztomographie. Limitierender Faktor fur die Bilddatenaquisition ist das variierende Atemverhalten der Patienten. Wahrend bei Kindern sich dieses Problem weniger gravierend manifestiert, kann beim Erwachsenen durch einen groseren Untersuc...
Conference Paper
PURPOSE High resolution magnetic resonance angiography (MRA) is preferably enabled by parallel image acquisition. The consecutive signal loss could be compensated for by increased field strength. Aim of our study was the intraindividual comparison of thoracoabdominal MRA at 1.5T and 3T. METHOD AND MATERIALS MRA was performed in 20 patients at 1.5T...
Article
The purpose of this prospective study was to determine the feasibility and accuracy of high-spatial-resolution MR imaging at 3 Tesla (T) in the preoperative evaluation of potential living related kidney donors. Eighteen potential donors (8 men, 10 women; mean age, 50.1 +/- 14.2 years) for renal transplantation were evaluated with 3 T MR imaging. A...
Article
The aim of the present study was to determine the correlation of myocardial perfusion MR imaging (MPMRI) and coronary angiography for the detection of flow-limiting stenosis in symptomatic patients with known coronary artery disease and a history of intervention. MPMRI was performed in 51 symptomatic patients (44 male, 64.7 +/- 9.5 years) with know...
Article
In patients with Kawasaki disease (KD) serial evaluation of the distribution and size of coronary artery aneurysms (CAA) is necessary for risk stratification and therapeutic management. To apply whole-heart coronary MR angiography (CMRA) and black-blood coronary vessel wall imaging in children with KD. Six children (mean age 4.6 years, range 2.5-7....

Citations

... Images with SEMAR showed decreased noise, increased contrast-to-noise ratio, image quality, increased diagnostic confidence and improved visualization of anatomical structures and arteries adjacent to metal in comparison to images without SEMAR [64][65][66][67]. iMAR also improves image quality and diagnostic confidence and allows more reliable detection of aneurysm reperfusion and aneurysm residual than images without iMAR [68][69][70][71]. However, iMAR may artificially reduce contrast in adjacent arteries [68]. ...
... In recent years, MRI-based techniques gained importance in assessment of the cerebral perfusion without the need for application of contrast agent [1,[5][6][7][8][9]. Namely, arterial spin labeling (ASL) became increasingly important in the last few years [10][11][12][13]. ...
... ZOOMit-DWI was performed with the following diffusion gradient b factors: 0, 500, 1000, 1500 and 2000 s/mm 2 . ZOOMit-DWI uses the availability of fully independent parallel radiofrequency transmission coils, allowing excitation of selective "inner volumes" (12). When the field of view is reduced, the readout tends to be faster which decreases the susceptibility artifacts. ...
... Several studies demonstrated that rsEPI provides superior image quality of dMRI measurements in the ON, compared with those acquired using a conventional singleshot EPI. [98][99][100][101][102][103] The drawback of this method is its prolonged acquisition time, which limits applicability to studies of clinical populations. Simultaneous multi-slice rsEPI 104 has been proposed to mitigate this limitation, and recent work demonstrated that it reduces image distortion of dMRI measurements of the ON and, therefore, reduces the impact of image blurring caused by distortion correction procedures on tractometry results. ...
... Several studies have revealed whether there is a correlation between IMR and PMI (19,20), showing that IMR is irrelevant to PMI. Similarly, Tanimoto et al. (21) concluded that IMR is caused by LV remodeling and that there is no evidence of a link to PMI. ...
... IVI with 2D selective excitations has been applied to image prostate, 42-46 orbits, [47][48][49] kidneys, 50 and other organs. [51][52][53] Recently, Malik and Hajnal 54 proposed a 3D pTx pulse design method to improve background suppression for a TSE sequence with long echo trains and low refocusing angles. Proper background suppression is key for a successful IVI particularly for selecting small volumes for excitation. ...
... Here both zoomed SPACE sequences were capable of replacing the standard-SPACE sequence at 3 T; however intracochlear and accurate imaging of the anatomy of the internal auditory canal (IAC) nerve benefits from the zoomed pTX-SPACE sequence. 13 The aim of the present study was to evaluate the performance of a pTX-SPACE sequence improved for spatial resolution in common temporal bone diseases and to compare the image quality to a standard-SPACE sequence exhibiting the same scan time at 3 T. ...
... В то же время технические проблемы в ходе установки стента, интраоперационные осложнения, возникновение которых во многом зависит от опыта хирурга, а также повторное заполнение аневризмы в отдаленном периоде не позволяют говорить о 100 % безопасности методики. Необходимо ее совершенствование как за счет улучшения практических навыков врача, так и за счет создания более простых в эксплуатации устройств [6,7]. Довольно трудным было применение ППС 1-го поколения вследствие технической сложности правильного их размещения в просвете несущей аневризму артерии. ...
... There were a total of 1734 results from the literature search with 22 studies meeting inclusion criteria Doronina et al., 2018;Hedman et al., 2015;Henriksen et al., 1999;Kooreman et al., 2019;Kramer et al., 2013;Lakatos et al., 2018;Leischik & Spelsberg, 2014;Leischik et al., 2016;Malmgren et al., 2015;Mangold et al., 2013;Petersen et al., 2006;Prakken et al., 2010Prakken et al., , 2011Sanz-de la Garza et al., 2017;Steding-Ehrenborg et al., 2016;Stolt et al., 2000;Venckunas et al., 2016;Zeldis et al., 1978). Of the studies that met the inclusion criteria, three were case series (Kooreman et al., 2019;Leischik & Spelsberg, 2014;Mangold et al., 2013), 16 were cross sectional (Doronina et al., 2018;Hedman et al., 2015;Henriksen et al., 1999;Kramer et al., 2013;Lakatos et al., 2018;Leischik et al., 2016;Malmgren et al., 2015;Petersen et al., 2006;Prakken et al., 2010Prakken et al., , 2011Sansonio de Morais et al., 2017;Sanz-de la Garza et al., 2017;Stolt et al., 2000;Zeldis et al., 1978), and three were cohort (with historical control) studies Steding-Ehrenborg et al., 2016;Venckunas et al., 2016). ...
... The translation of pTx hardware and design methods from UHF to 3T resulted in successful application of IVI using 2D selective excitations for turbo spin echo (TSE) sequences. IVI with 2D selective excitations has been applied to image prostate, 42-46 orbits, [47][48][49] kidneys, 50 and other organs. [51][52][53] Recently, Malik and Hajnal 54 proposed a 3D pTx pulse design method to improve background suppression for a TSE sequence with long echo trains and low refocusing angles. ...