A Rosztóczy's research while affiliated with University of Szeged and other places
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Publications (128)
BACKGROUND While capsule endoscopy (CE) is the gold standard diagnostic method of detecting small bowel (SB) diseases and disorders, a novel magnetically controlled capsule endoscopy (MCCE) system provides non-invasive evaluation of the gastric mucosal surface, which can be performed without sedation or discomfort. During standard small bowel capsu...
Összefoglaló közleményünket az endoszkópos szakmacsoport neves hazai szakemberei által kiválasztott,
a nemzetközi szakirodalomban az elmúlt évben megjelent legfontosabb közleményekből állítottuk
össze. Közleményünk segítséget nyújthat a hazai endoszkópos és gasztroenterológus kollégáknak
a szakmai újdonságok követésében és a legfontosabb nemzetközi...
Matrix metalloproteinase (MMP)-7, unlike many MMPs, is typically expressed in epithelial cells. It has been linked to epithelial responses to infection, injury, and tissue remodeling including the progression of a number of cancers. We have now examined how MMP-7 expression changes in the progression to esophageal adenocarcinoma (EAC), and have stu...
Background and Objectives
We wanted to assess our surgical results focusing on the patients' quality of life. We present our experience with laparoscopic surgery for epiphrenic esophageal diverticulum. Short- and long-term results of surgical therapy were analyzed.
Methods
Eight patients were examined with a symptom-causing epiphrenic diverticulum...
Esophagitis, whether caused by acid reflux, allergic responses, graft-versus-host disease, drugs, or infections, is a common condition of the gastrointestinal tract affecting nearly 20% of the US population. The instigating agent typically triggers an inflammatory response. The resulting inflammation is a risk factor for the development of esophage...
Barrett's esophagus (BE) is considered to be the most severe complication of gastro-esophageal reflux disease (GERD), in which the prolonged, repetitive episodes of combined acidic and biliary reflux result in the replacement of the squamous esophageal lining by columnar epithelium. Therefore, acid extruding mechanisms of esophageal epithelial cell...
Background:
Colorectal cancer (CRC) is one of the leading malignancies worldwide, therefore cheap noninvasive screening methods are of great importance. Matrix-metalloproteinase-9 (MMP-9) has a role in the progression of CRC, and its level is elevated in tumour biopsies. Faecal MMP-9 levels are increased in active ulcerative colitis patients, but...
Introduction:
Barrett's esophagus (BE) is the only known precursor of adenocarcinoma occuring in the lower third of the esophagus. According to statistics, severity and elapsed time of gastroesophageal reflux disease (GERD) are major pathogenetic factors in the development of Barrett's esophagus.
Patients and methods:
In a retrospective study be...
Irritable bowel syndrome (IBS) is a long-lasting, relapsing disorder characterized by abdominal pain/discomfort and altered bowel habits. Intestinal motility impairment and visceral hypersensitivity are the key factors among its multifactorial pathogenesis, both of which require effective treatment. Voltage-gated calcium channels mediate smooth mus...
Introduction: Epidemiologic studies indicate a decrease in prevalence of HP infection in Western Europe. In contrast, little is known about Central Europe, where substantial part of the population still lives outside of cities. Our preliminary results indicated a similar tendency in Hungary, although population based data were not available till no...
Background: Elevated gut permeability is linked to visceral hypersensitivity in patients with IBS. Using transgenic mice that express constitutively-active myosin light chain kinase (CA-MLCK) specifically within the intestinal epithelium in this way having gut hyperpermeability, we aimed to evaluate the pattern of visceral sensitivity and to determ...
Introduction: Most population based epidemiologic studies indicate approximately 20% prevalence of gastro-oesophageal reflux (GOR) related typical symptoms appearing at least monthly. Since most of these works were carried out in the western countries, a little is known about Central Europe, where substantial part of the population still lives outs...
Acute pancreatitis recently became the most common cause for hospitalization among gastrointestinal diseases. There is no specific therapy against the disease due to insufficient understanding of pathogenesis. Animal and in vitro models indicated that reduced pancreatic ducal bicarbonate secretion and consequent intraductal acidosis is an early eve...
Objectives:
Luminal serine-proteases lead to increased colonic paracellular permeability and visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome (IBS-D). Other proteases, namely cysteine-proteases (CPs), increase airway permeability by digesting epithelial tight junction proteins. In this study, we focused on c...
Introduction: Previously we have shown that fecal cystein-protease activity is significantly elevated in IBS-C patients compared to control subjects. In animal experiments, colorectal infusion of fecal supernatants from IBS-C patients increase gut paracellular permeability and provokes a visceral hypersensitivity to distension. This increase is lin...
Background:
Ulcerative colitis (UC) is characterized by frequent relapses, with the presence of colorectal inflammation and mucosal lesions. Matrix-metalloprotease 9 (MMP-9) is elevated in colonic biopsies, urine, and blood plasma of UC patients. MMP-9 has been suggested as a predictor of UC in the urine of children; however, 20% of the controls t...
Defective epithelial barrier has been implicated in the pathogenesis of irritable bowel syndrome (IBS) and inflammatory bowel diseases. The aim of this study was to investigate gut permeability in patients with inactive ulcerative colitis (UC) and in patients with IBS.
IBS patients of the diarrhea-predominant (IBS-D) and of the constipation-predomi...
The aim of our study was to conduct a retrospective investigation of the efficacy of laparoscopic Nissen fundoplication in patients with Barrett's esophagus.
A total of 78 patients with Barrett's esophagus underwent surgery. Patients were divided into three groups on the basis of the preoperative endoscopic biopsies: a non-intestinal group (n = 63)...
To evaluate the oesophageal function in patients with different types of oesophageal metaplasia and in cases with dysplasia on the basis of the Montreal definition of gastro-oesophageal reflux disease.
270 consecutive patients [M/F 151/119, mean age 54.2 years (19-84)] with endoscopic and histological evidence of oesophageal metaplasia were prospec...
Although the pathogenesis of cervical inlet patch (CIP) is not fully understood, most authors consider it as a congenital abnormality, whereas others surmise it to be related to gastroesophageal reflux disease (GERD). We aimed to evaluate esophageal function and the prevalence of GERD and Barrett's esophagus in patients with CIP. GERD is defined by...
Activation of proteinase-activated receptor-4 (PAR-4) from the colonic lumen has an antinociceptive effect to colorectal distension (CRD) in mice in basal conditions. We aimed to determine the functional localization of the responsible receptors and to test their role in two different hyperalgesia models.
Mice received PAR-4 activating peptide (PAR...
Specialized intestinal metaplasia (SIM) is considered as a premalignant condition of the esophagus, but other types of esophageal metaplasia are commonly neglected. A standardized histopathological analysis was focused not only on SIM but also on the presence of metaplastic processes typical of additional glands. A morphological study using standar...
The resistance of Helicobacter pylori to antimicrobial agents, and particularly to metronidazole and clarithromycin (CLA), is an important factor affecting the outcome of standard treatments for H. pylori eradication. Primer resistance to CLA were found 8.9% in our study in Szeged between 2003 and 2004. Aim: To study the occurrence of CLA-R of in H...
Fecal serine-protease activity is elevated in diarrhea type irritable bowel syndrome (IBS-D), and this luminal factor enhances colonic permeability and colorectal sensitivity in mice when infused intracolonically (ic.). Rectal hypersensitivity has been described in all IBS subgroups, including constipation predominant IBS (IBS-C). Other proteases,...
It is known that the increase of the COX-2 expression is an early step in the sequence of malignant transformations including Barrett's metaplasia and esophageal adenocarcinoma. Furthermore retrospective studies have shown a decreased incidence of esophageal adenocarcinoma in patients on aspirin treatment. Aim: to determine changes of COX-2 express...
Background: Our previous studies have demonstrated that the nitrergic subpopulation of myenteric neurons is especially susceptible to neurodegenerative changes in a streptozotocine-induced rat model of diabetes. The loss of modulatory role of endothelium in capillaries supplying the myenteric plexus has been proposed as a potential mechanism underl...
Introduction: Active ulcerative colitis (UC) is characterized by tight junction alterations and increased gut permeability. Matrix-metalloprotease 9 (MMP-9) is capable of occludin degradation and disruption of the epithelial barrier, while increased PAR-2 promoter methylation was shown in patients with severe forms of the disease. Our aims were: 1....
Elevated colonic luminal serine-protease (Ser-P) activity of diarrhea-predominant IBS (IBS-D) patients evokes a proteinase-activated receptor (PAR)-2-mediated colonic hypersensitivity in mice. Despite similarly elevated Ser-P levels in feces, patients with IBD exhibit visceral hypo- or normosensitivity to rectal distension, as opposed to IBS-D. To...
The prevalence of gallstones in patients with Barrett's esophagus (BE) and their gallbladder motility relative to that of healthy volunteers and GERD patients without BE were investigated. Of the 707 patients reviewed, 203 (125 males and 78 females) had BE. The prevalence of gallstones was significantly higher in the patients with BE than in those...
To evaluate the prevalence of proximal reflux and esophago-bronchial reflex (EBR) in patients with asthma, and to compare the symptom spectrum, esophageal acid sensitivity, pH monitoring, and the endoscopic and manometric parameters of EBR-positive and -negative patients with asthma.
Forty-three consecutive patients with recent diagnoses of asthma...
The streptozotocin-induced diabetic rat model was used to investigate the relation between the deranged gut motility and the segment-specific quantitative changes in the nitrergic myenteric neurons. Additionally, we studied the effectiveness of early insulin replacement to prevent the diabetes-induced changes. Rats were divided into three groups: c...
Diarrhoea-predominant irritable bowel syndrome (IBS-D) is characterised by elevated colonic lumenal serine protease activity. The aims of this study were (1) to investigate the origin of this elevated serine protease activity, (2) to evaluate if it may be sufficient to trigger alterations in colonic paracellular permeability (CPP) and sensitivity,...
The aims of the study were to assess pathogenetic role of gastro-oesophageal reflux and the oesophago-cardiac reflex in subjects with chest pain. To evaluate the prevalence of gastro-oesophageal reflux disease and the oesophago-cardiac reflex in patients with different coronary artery diseases and in coronary spasm.
Fifty-one patients with chest pa...
The pathogenesis of irritable bowel syndrome (IBS) remains only partially understood, and no specific or universally effective patient management procedure has been developed to date. Our study was designed to evaluate if colonic luminal serine-proteases may be a relevant pathophysiologic marker of IBS.
Fecal samples of 38 IBS patients, 15 patients...
Neonatal maternal deprivation (NMD) increases gut paracellular permeability (GPP) through mast cells and nerve growth factor (NGF), and modifies corticotrophin-releasing factor (CRF) and corticosterone levels. CRF, corticosterone and mast cells are involved in stress-induced mucosal barrier impairment. Consequently, this study aimed to specify whet...
Citations
... There are a wide variety of surgical procedures for esophageal diverticulum. The basic technique is resection of the diverticulum, with the addition of myomectomy or diverticuloplasty [6]. At this point, there is still much debate as to which technique should be chosen [7]. ...
... A previously well-characterized CCK2R antibody [19,20] revealed some level of CCK2R expression by tumor cells in 15 out of the 18 MM patients compared with 2 out of the 10 BCC patients used as controls ( Figure 1B). In the majority (56%) of the MM patients, the percentage of melanoma cells that exhibited CCK2R expression ranged from 15% to 20%, while in the expression in the remaining cases varied between undetectable (17%) and homogenous strong positivity (27%). ...
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... Proteinase-activated receptors have been implicated in the development of visceral hypersensitivity in IBS patients. In a recent study, fecal serineprotease activity was assessed in 38 IBS patients, 15 patients with ulcerative colitis, and 15 healthy controls (93) . Fecal serine protease activity was threefold higher in IBS-D patients than in controls or patients with nondiarrheal IBS; fecal serine protease levels also were elevated in the ulcerative colitis patients. ...
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... The significance of Pancreatic Acinar Metaplasia (PAM) is still not established well. The prevailing opinion in many clinical studies which is still adopted by many pathologists suggested that PAM is an incidental finding, [1,2] which we doubt, depending on several published studies [3,4,5,6] and according to our observations in the case that we are presenting here, which provide a preponderance of evidence supports the significance of PAM at the lower esophagus. ...
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... The advancement of 3D models is growing exponentially, bridging the gap between traditional 2D monolayer cultures and complex animal models [213]. Three-dimensional assays have been employed to study the esophageal response to inflammation [214], pancreatic ADM [215], IBD [216], and colorectal cancer carcinogenesis [217]. In addition, the development of immunocompetent 3D mucosal models that recapitulate the colonic mucosa offers a unique opportunity to study different immunological scenarios mimicking human physiology and pathology ( Figure 4B). ...
... The transport of glutamine, a non-essential neutral amino acid, is conducted by SLC families 1, 6, 7 and 38, and the intracellular requirements of this amino acid are necessary for the synthesis of the antioxidant glutathione [40]. With respect to chemotherapeutic treatment of EAC patients, a number of SLC family members, including SLC22A2, are responsible for the uptake of 5-fluorouracil (5-FU), cisplatin, carboplatin, and paclitaxel, and in turn impact cancer cell death, pathological progression, therapeutic efficacy, and patient prognosis [45][46][47][48][49][50][51][52][53][54][55]. ABC transporters are primary active transporters that utilize energy from ATP hydrolysis to move a wide range of substrates generally to the outside of a cell [22]. ...
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... Fecal MMP-9 might be used as a non-invasive-biomarker Prognostic [150] as a biomarker in evaluating the condition of IBD patients. Additionally, we mentioned extra non-invasive biomarkers which can be useful in IBD and CRC management. ...
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... These changes were not detected in PAR2¡/¡ mice. 147 Additionally, IBS-D patients who carry either the HLA-DQ2 or DQ8 genotype have increased gut permeability compared to IBS-D who do not carry one of those HLA genotypes. 148 Taken together, these data suggest zonulin signaling through PAR2 may be involved in the pathogenesis of IBS-D. ...
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... disorder for individuals with Barrett's esophagus, a gastrointestinal complication of GERD. [58,59] We identified multiple associations between diet and FRDs. Tofu consumption was associated with significantly decreased odds of endometriosis. ...
... The inhibition of cyclooxygenase-2 (COX-2) -found to be elevated in epithelial cells of BE during the progression from low-grade to high-grade dysplasia (precursor to EAC) (33) -has been proposed as a possible chemoprotective mechanism (34). However, selective COX-2 inhibitors had no effect on the incidence of EAC (34)(35)(36). Interestingly, nonselective NSAID (nsNSAID) -especially aspirin (irreversible COX-1/2 inhibitor)are strongly associated with decreased risk of EAC in patients with BE (37). Furthermore, this protective effect was also evident with the concomitant use of PPIs, demonstrating a longitudinal-response relationship -the longer the use, the lower the risk (34,38). ...
