A G Montag's research while affiliated with University of Chicago and other places

... Insulin-degrading enzyme (IDE) is a ubiquitously expressed zinc metalloendopeptidase [1]. It was initially identified as an insulin-clearing enzyme (the role for which it was named) [2]. ...

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Possible Role of Insulin-Degrading Enzyme in the Physiopathology of Retinitis Pigmentosa

... Other differential diagnostic considerations may be lymphoma, chronic osteomyelitis, osteoblastoma, and osteoid osteoma. Complications that occur predominantly in the pelvic region are osteoarthritis, fractures (proximal femur) and Paget sarcoma (usually osteosarcoma in iliac bone and proximal femur)789. ...

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Bone and soft tissue tumors of hip and pelvis

... ej., TNFα, INFγ, etc.). Empleando técnicas de biología molecular, surgió TPB, la versión humanizada de OKT3, que mantie-ne la especificidad por el CD3, pero con cambios de aminoácidos (Ala en las posiciones 234 y 235) 27 . ...

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Teplizumab: toma de posición de la Sociedad Argentina de Diabetes

... Après avoir été démontré compétiteur, CTLA-4 a été démontré inhibiteur de la réponse immunitaire (Lenschow et al., 1992(Lenschow et al., , 1993Walunas et al., 1994). Ces propos servent ainsi la pertinence d'étude et de considération des molécules CD80 et CD86, au vu de leur implication dans la régulation de la réponse immunitaire. ...

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Étude de l'implication de l'activateur tissulaire du plasminogène dans la réponse immunitaire

... E-cadherin overexpression is a positive prognostic factor in the clinical course of endometrioid endometrial cancer [117]. High E-cadherin expression is associated with reduced mortality, disease progression, and rate of disease recurrence [118]. ...

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The significance of markers in the diagnosis of endometrial cancer

... Current-day treatment of ABC advocated by many is curettage with or without bone graft. To augment this procedure, high-speed burr has been described by one study done by Gibbs et al., [20] where 40 patients showed nearly 90% control rate after a median 7.2-year follow-up, following curettage, without the use of phenol, liquid nitrogen, or any other adjuvant. Burr works by mechanical disruption of the lesion to the level of the bone circumscribing the lesion. ...

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Management of Proximal Femur Aneurysmal Bone Cyst with 10-year Follow-up – A Case Report

... There is also a model of spontaneous EAN in non-obese diabetic (NOD) mice that are deficient in the co-stimulatory B7-2 molecule (154). In this model there is inflammation and demyelination of peripheral nerves, with a chronic course. ...

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Sex differences in Guillain Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and experimental autoimmune neuritis

... Based on this approach, a new wave of immunotherapieshas surfaced. One of the pioneering ones includes the generation of a chimeric CTLA-4-Ig protein, which is responsible for blocking co-stimulation through CD28 (Lenschow et al. 1992). Potent activation of TCR signalling cascade is highly dependent on the interaction of CD28 on T cells and its ligands, CD80 or CD86 on APCs. ...

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Immunomodulation in Autoimmune Disorders

... Both are ligands for programmed death-1 (PD-1), which is expressed on activated T and B cells [4][5][6]. PD-L1 has been described to be inducibly expressed in a variety of organs [3,[7][8][9][10][11][12][13]]. An overwhelming number of studies supported the role of PD-L1 as a negative regulator of T cell responses and suggest that PD-L1 promotes peripheral tolerance [14]. ...

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PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

... A recent study by Brouwers et al. demonstrated a novel molecular mechanism of one of the most extensively studied proprotein convertases (PCs), furin, in regulating glucose levels in β-cells [29]. PCs are proteolytic enzymes that are ubiquitously involved in many biological processes and play crucial roles in regulating metabolic diseases [30,31]. In their study, they showed that the absence of furin-mediated mTORC1 activation led to β-cell dysfunction (Figure 2 bottom panel) [29]. ...

Reference:

mTOR: Its Critical Role in Metabolic Diseases, Cancer, and the Aging Process