A Capron's research while affiliated with Unité Inserm U1077 and other places

... In a similar study, recombinant schistosome P28GST improved colitis symptoms in rats, which has been related to a Th2 shift of the immune response (79). S. heamatobium is closely related to S. mansoni, and the P28GST protein expressed by S. mansoni has been described to protect against inflammation (80,81). Thus, proteins with known immunomodulatory properties derived from S. mansoni or its close relatives have the potential of being used in the clinic to treat inflammatory disorders. ...

... The experimental conditions described in the first papers on cytokine determination [17,18] where later often modified, as required in different experimental models. Mice have usually been immunised once or several times and secondary lymphoid organs taken for the in vitro tests seven or more days after the last immunisation [19][20][21][22][23][24][25][26][27][28][29]. In some experiments, these secondary organs were draining the site of inoculation, while in others spleens were used regardless of the route of immunisation. ...

... Sh28GST with Freund's complete ad- juvant elicited specific IgG and IgA responses in all immunized animals, which strongly supports satisfactory antibody coverage in future vac- cinated human populations. Glutathione S-transferase is preserved in S. mansoni, S. haematobium, S. japonicum, and S. bovis and this conserva- tion can be explored in the context of vaccine development, which can simultaneously eliminate different Schistosoma species ( Boulanger et al., 1999Boulanger et al., , 1995Fonseca et al., 2015). ...

... However, it is important to note that the use of solvents can cause denaturation of protein-based drugs hence giving rise to variability in encapsulation efficiencies and also loading capacities (Yang et al. 2000). The use of high shearing forces in this methodology can also contribute to the degradation of a sensitive antigen (Baras et al. 2000). Another major drawback of the emulsion technique is its production of inhomogeneous particles, which leads to their lack of reproducibility thus limiting their clinical use as monodispersity in terms of size of a sample is a critical factor as it gives better control of drug release profiles and bioavailability of the loaded drug (Valo et al. 2009). ...

... les mêmes résultats ont été observé chez des patients piqués accidentellement par le venin de Centruroides vittatus (More et al., 2004). L'infiltration des éosinophiles dans l'arbre pulmonaire est souvent observée dans (Capron et al., 2002). L'infiltration des polynucléaires neutrophiles au niveau de l'arbre pulmonaire est signe de syndrome de détresse respiratoire aigue (SDRA) (Park et al., 2001 ;Goodman et al, 2003). ...

... It is well established that chemical messenger cross talk occurs between certain parasites and their specific hosts, including those found in humans (4)(5)(6)(7)(8). The use of common signaling molecules in this relationship has been documented (5,(9)(10)(11). ...

... The characteristics of GST are summarized in Figure 1 (143)(144)(145)(146)(147)(148)(149)(150)(151); detailed pre-clinical and clinical studies of the candidate are provided in Supplementary Table S4. ...

... From these results, it appears that a large proportion (more than 55%) of the proteins identified can be defined as potentially protective antigens. These proteins display qualitative and ⁄ or quantitative differences among clones that could be linked to differences in transcriptional, post-transcriptional or post-translational regulation processes or to single-nucleotide polymorphisms (Pierce et al., 1994;Simoes et al., 2007), which can change physicochemical properties and the positions of the proteins in the gels. Fig. 1 Relation of the infectivity rate to genetic dissimilarity between immunizing clones and the reference clone. ...

... The heavy chain fragment of the tetanus toxin is marked by its antigenic and immunogenic properties [9], which is related to effective, specific, and safe antitoxin vaccines [10]. This fragment stands out by its ability to induce the production of antibodies when used as a fusion partner for foreign antigens [11][12][13]. Tetanus toxin fragment adjuvant potency is related to the presence of promiscuous T-lymphocyte epitopes in the protein [14]. The tetanus toxoid protein contains several T-lymphocyte epitopes (p2, p21, p23, p30, and p32), which have been extensively studied. ...

... Schistosomes have been shown to produce levels of adrenocorticotropic hormones, which, when processed by human polymorphonuclear leukocytes into alpha-melanotropin, results in the subsequent inactivation of these cells, and could potentially decrease Th1 cell activation (143,144). Additionally, schistosomes have the capacity to generate substances bearing similarities to morphine and codeine, which had the effect of decreasing leukocyte activation (144,145). ...