Humans have interacted with the landscape and ecosystem of New Mexico's Rio del Oso Valley for thousands of years. Throughout the Holocene, various cultures have dramatically affected and altered the Rio del Oso. An interdisciplinary research approach, incorporating geomorphology, paleobotany, archaeology, and history, provides a broad range of methodologies and data sets of past landscape dynamics. Integrating such data sets in three-dimensional Geographical Information Systems (GIS) models of past vegetation and landscape conditions may enable a view of anthropogenic ecosystem change. Analyses of past land use through landscape models, geoarchaeology, and other methods can provide a greater understanding for current and future ecosystem management.