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Differential Increases in Excess Mortality in the German Federal States During the COVID-19 Pandemic

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Abstract and Figures

Background: The present study investigates the influence of COVID-19 on mortality in the sixteen German federal states. To examine this issue, we estimate the burden of the COVID-19 pandemic separately for each federal state by calculating state-specific excess mortalities for the three pandemic years and explore a number of key state-specific quantities to determine the extent to which these covary with the excess mortality. Among the explored quantities are aspects related to the pandemic (strength of measures, COVID-19 infections and vaccination rates) and aspects unrelated to the pandemic (mean age, gross domestic products, poverty rates, proportions of people in need of care). Methods: To estimate excess mortality, we compare in each federal state the observed number of all-cause deaths with the number of the statistically expected all-cause deaths. To estimate the expected number of deaths, we use German life tables and longevity trends, and state-specific population tables and state-factors. The results yield for each federal state separate estimates for the expected number of all-cause deaths if there had been no pandemic. Results: Excess Mortality varied substantially across federal states in each of the pandemic years. In nearly all states, excess mortality was small in the first pandemic year, increased in the second and even more in the third pandemic years. The increase varied substantially across the federal states as well. Regarding the covariations with the explored state-specific quantities, two correlation patterns are noticeable. In the first two years of the pandemic, but not in the third, there was a strong correlation between excess mortality and the number of reported COVID deaths, suggesting that the differences in excess mortality observed earlier in the pandemic are due to differences in the levels of exposure to COVID-19. However, this cannot explain the increase of excess mortality in the second and third pandemic years because the number of COVID-19 deaths decreased instead of increased in almost all federal states. Regarding the increase in excess mortality, an increasingly strong positive correlation with the vaccination rate of a federal state is observed, which reaches a value of r = 0.85 in the third pandemic year, indicating that excess mortality increased the stronger the higher the vaccination rate in a federal state was. An analysis of stillbirths showed exactly the same pattern. No other systematic correlation pattern was observed. Conclusions: Excess mortality during the pandemic varied substantially between federal states, a finding that requires explanation. While the positive correlation of excess mortality with COVID-19 infections and deaths in the the phase of the pandemic without vaccinations suggests an explanation through different levels of exposure to COVID-19, COVID-19 cannot explain the increase in excess mortality after vaccinations began. For the second and third pandemic year a significant positive correlation between the increase of excess mortality and COVID-19 vaccinations is observed, a fact that strongly calls for further investigations on possible negative effects of COVID-19 vaccinations.
Relationship between stillbirths and vaccination rates. (A) shows the relationship between the vaccination rate in a federal state and the number of stillbirths per 1,000 total births is shown in the first (2020), second (2021), and third (2022) year during the pandemic. (B) shows the increase in stillbirths from the first to the second (from 2020 to 2021) and the third (from 2020 to 2022) year during the pandemic in pro mille points in the individual federal states as a function of the vaccination rate in a federal state. In 2020, a negative correlation between the number of stillbirths and the vaccination rate in the subsequent year 2021 is observed (r = −0.66, p = 0.007). That is, in the federal states in which the stillbirth rate was lowest in 2020 before the vaccinations started, most people were vaccinated the following year 2021. The negative correlation decreases in the year 2021 where the vaccinations started (r = −0.29, p = 0.290) and turns around and becomes positive in 2022 (r = 0.33, p = 0.234). As shown in Figure 6B, this is further supported by an analysis of the increase in the number of stillbirths from the first to the second (from 2020 to 2021) and the third (from 2020 to 2022) year during the pandemic. Already for the increase in the second year, a moderately strong positive correlation is observed (r = 0.37, p = 0.178), and in the third pandemic year, a strong positive correlation is observed (r = 0.72, p = 0.002), indicating that the increase in stillbirths was the higher the higher the vaccination rate. Note that the reported values refer to the federal states without the smallest federal state of Bremen, because Bremen was a strong outlier in in 2020 and 2022 (in both years stillbirth rate more than three standard deviations above the mean occur); including Bremen did not change the observed result pattern.
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Differential Increases in Excess Mortality
in the German Federal States
During the COVID-19 Pandemic
Christof Kuhbandnerand Matthias Reitzner
Abstract
Background: The present study investigates the influence of COVID-19 on mortality in the
sixteen German federal states. To examine this issue, we estimate the burden of the COVID-
19 pandemic separately for each federal state by calculating state-specific excess mortalities
for the three pandemic years 04/2020-03/2021, 04/2021-03/2022, and 04/2022-03/2023, and
explore a number of key state-specific quantities to determine the extent to which these covary
with the excess mortality. Among the explored quantities are aspects related to the pandemic
(strength of measures, COVID-19 infections and vaccination rates) and aspects unrelated to
the pandemic (mean age, gross domestic products, poverty rates, proportions of people in need
of care).
Methods: To estimate excess mortality, we compare in each federal state the observed
number of all-cause deaths with the number of the statistically expected all-cause deaths.
To estimate the expected number of deaths, we use German life tables and longevity trends,
and state-specific population tables and state-factors. The results yield for each federal state
separate estimates for the expected number of all-cause deaths if there had been no pandemic.
Results: Excess Mortality varied substantially across federal states in each of the pandemic
years. In nearly all states, excess mortality was small in the first pandemic year, increased in the
second and even more in the third pandemic years. The increase varied substantially across the
federal states as well. Regarding the covariations with the explored state-specific quantities, two
correlation patterns are noticeable. In the first two years of the pandemic, but not in the third,
there was a strong correlation between excess mortality and the number of reported COVID
deaths, suggesting that the differences in excess mortality observed earlier in the pandemic are
due to differences in the levels of exposure to COVID-19. However, this cannot explain the
increase of excess mortality in the second and third pandemic years because the number of
COVID-19 deaths decreased instead of increased in almost all federal states. Regarding the
increase in excess mortality, an increasingly strong positive correlation with the vaccination
rate of a federal state is observed, which reaches a value of r= 0.85 in the third pandemic
year, indicating that excess mortality increased the stronger the higher the vaccination rate
in a federal state was. An analysis of stillbirths showed exactly the same pattern. No other
systematic correlation pattern was observed.
Conclusions: Excess mortality during the pandemic varied substantially between federal
states, a finding that requires explanation. While the positive correlation of excess mortality
with COVID-19 infections and deaths in the the phase of the pandemic without vaccinations
suggests an explanation through different levels of exposure to COVID-19, COVID-19 cannot
explain the increase in excess mortality after vaccinations began. For the second and third
pandemic year a significant positive correlation between the increase of excess mortality and
COVID-19 vaccinations is observed, a fact that strongly calls for further investigations on pos-
sible negative effects of COVID-19 vaccinations.
Keywords: expected number of deaths, COVID-19, excess mortality in German federal states
Christof.Kuhbandner@psychologie.uni-regensburg.de
matthias.reitzner@uni-osnabrueck.de
1
1 Introduction
The development of mortality since the beginning of the COVID-19 pandemic has been intensively
examined in previous research. In several countries, a surprising pattern is observed. While
mortality increased only marginally beyond the mortality level observed in prepandemic years in
2020, mortality started to increase in the year 2021, reaching extraordinarily high levels in 2022
(e.g., Australian Bureau of Statistics [1]; Kuhbandner and Reitzner [20]; Kye [21]; Scherb and
Hayashi [27]). An impressive example is Germany, as shown in a recent paper where the excess
mortality observed in Germany was estimated based on the state-of-the-art method of actuarial
science, using population tables, life tables, and longevity trends (Kuhbandner and Reitzner [20];
for similar results, see oßler et al. [26]; Scherb and Hayashi [27]). This is illustrated in Figure
1 which shows the number of excess deaths, estimated with this method, observed in 2020, 2021,
and 2022 (for details see the method and result sections below).
Figure 1: Number of excess deaths in Germany in the years 2020, 2021, and 2022
Given the surprising finding that a significant excess mortality only begins to appear in 2021,
which then doubles in the following year 2022, the question arises which factors might be related
with this sudden and strong increase in mortality long after the start of the pandemic. One way to
approach this question is to examine to what extent the excess mortality observed in the different
federal states of Germany varies with different state-specific quantities.
In fact, such a research strategy has already been used in a previous study where it has been
examined whether the excess mortality observed in the different German federal states in the
second half of 2021 varies with the COVID-19 vaccination rate in a federal state (Thum [32]).
According to the results of this study, a significant negative correlation was observed, that is, the
higher the vaccination rate in a federal state, the lower the excess mortality, a finding that was
interpreted in several media as evidence of the effectiveness of the vaccinations.
However, drawing such a conclusion from this study is problematic due to several reasons.
First, the method used in the study to estimate excess mortality does not meet current scientific
standards. The number of expected deaths is simply determined by the mean age-standardized
death rate across the years 2016-2019. While such an estimation method at least takes into
account effects of changes in the size and age profile of the population, effects of historical trends
in the development of mortality are ignored. However, as shown in a recent study, since mortality
probabilities are still decreasing in Germany from year to year, ignoring mortality trends leads to
biased estimates of excess mortality (Reitzner [24]).
Second, the correlation between excess mortality in the second half of 2021 and the vaccination
rate was only computed for the vaccination rate at a relatively arbitrary point in time (proportion
of the population with at least one first vaccination on September 30, 2021). Thus, it remains to
be shown whether the observed correlation at this specific time point also generalizes to other time
points and to the rate of second and third vaccinations.
2
Third, the observed negative correlation between the vaccination rate and excess mortality may
actually not reflect a causal effect of the vaccinations. Since there are numerous other variables
beyond the vaccination rate in which the different federal states differ, the observed negative
correlation between the vaccination rate and excess mortality may actually be driven by third
variables. That is, there may be time-stable factors that are independent of vaccination, which
lead to excess mortality being generally lower in some federal states, and coincidentally, in the
federal states with a generally lower excess mortality rate, more vaccinations were carried out.
In fact, this possibility is mentioned in the study of Thum [32] itself, and an attempt is made
to rule it out by examining whether there is also a negative correlation between the vaccination
rate in 2021 and excess mortality in 2020. Since the vaccination rate in 2021 cannot account for
the excess mortality observed in 2020, finding a negative correlation between the vaccination rate
in 2021 and excess mortality in 2020 as well would mean that the negative correlation between
vaccination rate and excess mortality observed in 2021 actually reflects the effects of time-stable
third variables rather than a causal effect of the vaccinations. While such a research approach is in
fact a simple and straightforward method to investigate the existence of possible third variables,
the implementation of this method in the study by Thum [32] is questionable. Instead of simply
reporting the observed correlation between the vaccination rate in 2021 and the excess mortality
in 2020, the author only writes that the same federal state as in 2021 is indeed also at the top of
excess mortality in 2020, but that the other federal states would hardly differ from each other in
2020. Thus, it remains unknown whether the vaccination rate correlates not only negatively with
excess mortality in the year 2021 but also in the year 2020.
The aim of the present study was to estimate excess mortality in the individual German federal
states using scientifically sound methods, and to explore the relationship between excess mortality
and several other key state-specific quantities beyond the vaccination rate of a federal state. Excess
mortality was estimated based on the state-of-the-art method of actuarial science, using popula-
tion tables, life tables, and longevity trends (Kuhbandner and Reitzner [20]). The state-specific
quantities that were explored were numbers of COVID-19 deaths and infections, vaccination rates,
strength of measures taken against COVID-19, gross domestic products as a measure of the wealth
of a federal state, poverty rates, mean age, and proportions of people in need of care.
2 Methods
2.1 Mortality Probabilities and Population tables
The standard method to compute the expected number of deaths in insurance mathematics consists
of taking the population table containing the number lx,t of living x-year old male, resp. the number
ly,t of living y-year old female at the beginning of year t, and multiply it in a suitable way (see (2))
by the male mortality probabilities qx,t, respectively female mortality probabilities qy,t for year t
which are contained in a life table. The most recent population tables and life tables are published
annually by the German Federal Statistical Office.
To estimate the excess mortality in a pandemic situation, one calculates the number of expected
deaths if there had been no pandemic. Hence, we use the mortality probabilities qx,2019, qy,2019 of
the last prepandemic 2017/19 life table [8] of the Federal Statistical Office of Germany as the base
life table. Because there is a well visible mortality and longevity trend, we use longevity factors
Fm(x), Ff(y) which are taken from the DAV 2004R [15] to obtain the mortality probabilities
qx,t, qy,t for the pandemic years t= 2020,2021 and 2022. This is consistent with our previous
investigation [20] concerning the excess mortality for Germany. We refer to [20] for a discussion
concerning the use of different life tables, and to [24] for a discussion of the need and the (slightly
conservative) choice of longevity factors and the 2017/19 life table. These considerations lead to
3
German mortality probabilities
qx,t =qx,2019e(t2019) 1
2Fm(x)and qy,t =qy,2019 e(t2019) 1
2Ff(y)(1)
for t= 2020,2021 and 2022.
Before multiplying the population size with the mortality probabilities, one has to take into
account the birthday problem. Someone dying at age xcould have been of age x1 or xat the
beginning of the year, depending on his birthday and the precise date of death. As explained in
detail in [20] this leads to
EDx,t =lx1,t
2
qx1,t +qx,t
2+lx,t
2
qx,t +qx+1,t
2.(2)
Analogous formulas lead to EDy,t, and by summation we obtain the total number of expected
deaths,
EDt=
100
X
x=0
EDx,t +
100
X
y=0
EDy,t.
The expected number has to be compared to the observed number of deaths ˆ
dtin year t.
In our recent paper [20], this method has been used to compute the expected number of deaths
EDtfor the years t= 2020,2021 and 2022 for Germany. Since the publication of this paper, the
population table for 2023 was published by the German Federal Statistical Office and the number
of deaths for 2022 and partially for 2023 have been updated. This allows to compute the expected
number of deaths EDtfor t= 2023 and to state the final results for 2022. Because the number of
deaths for 2023 are still preliminary and partially not available, we refrain from including estimates
for ˆ
d2023. According to [20, Table 3] with the mentioned updates this yielded the following
Table 1.
Table 1: Expected and observed number of deaths 2020–2023
2020 2021 2022 2023
expected EDt981,557 989,707 998,241 1,004,882
observed ˆ
dt985,572 1,023,687 1,066,341
However, looking at calendar years has two major disadvantages. First, since the corona
pandemic only had an impact on mortality from around April 2020 onwards, segmentation into
calendar years underestimates the influence of the corona pandemic on deaths in 2020 compared
to subsequent years, where over the entire year Corona has had effects. Second, during the pan-
demic, the strongest wave of deaths in Germany was typically observed around the turn of the
year. Segmentation in the form of calendar years has the disadvantage that these strong waves
of mortality are artificially cut apart and assigned to different year segments, which can lead to
distortions.
Fortunately, as shown in our previous paper [9] (see Tables 1 and 2), the expected number of
deaths can be distributed onto months using the ‘typical’ behaviour in the years 2010 2019. This
opens a possibility to introduce pandemic years, the first P1from 04/20 to 03/21, the second P2
from 04/21 to 03/22, and the third P3from 04/22 to 03/23. According to [20, Table 13] again
suitably updated we obtained the excess mortalities in these pandemic years in Table 2.
4
Table 2: Expected and observed number of deaths in the pandemic years
04/20–03/21 04/21–03/22 04/22–03/23
expected EDPi981,656 992,127 1,000,102
observed ˆ
dPi1,004,061 1,019,100 1,077,884
2.2 Excess Mortality in the German Federal States
In this paper we will apply these methods to the 16 German states and compare the occurring excess
mortalities, resp. mortality deficits. To this end we start with the German population table lx,t and
the state population tables containing lst
x,t for 16 states st,= 1, . . . 16, with x= 0,...,100, for
the years t= 2009,...,2023. These tables have been provided by the German Federal Statistical
Office, and the Statistical Offices of all German states, except for Rhineland-Palatinate, where the
Statistical Office of Rhineland-Palatinate claimed that these numbers for the age groups x90
are too imprecise to be offered. Due to the relation
lx,t =
16
X
=1
lst
x,t
we could reconstruct the missing numbers of the population tables for Rhineland-Palatinate.
For the years t= 2009,...,2023 the German Federal Statistical Office publishes the observed
monthly number of deaths ˆ
dst
x,t for each of the 16 states st,= 1,...,16 for the age groups
[0,64],[65,74],[75,84] and the age group 85.
At a first step one could use the mortality probabilities of the life table 2017/19 of the German
Federal Statistical Office for all German states. It turns out that the obtained results do not fit to
historical data from the years 2009 2019. For nearly all German states, the mortality probabilities
deviate systematically from the mortality probabilities for the whole of Germany. Accordingly,
when using the German-wide mortality probabilities of the life table 2017/19, the excess mortality
in the different federal states would be systematically overestimated or underestimated. This
problem is illustrated in Figure 2 below using the two federal states of Baden-W¨urttemberg and
Saxony-Anhalt that deviate most strongly from the Germany-wide mortality probabilities of the
life table 2017/19.
Hence to adapt the German mortality probabilities qx,t, qy,t , we introduce state factors βst,
= 1,...,16, to obtain state mortality probabilities
qst
x,t =βstqx,t and qy,t =βstqy,t .(3)
The state factors βstwill be chosen to best fit historical data from 2009 to 2019 in the next section.
2.2.1 State Factors Adjusting Mortality Probabilities
In the same way as described above, we compute the expected number EDst
x,t of xyear old male
deaths in state stby
EDst
x,t =lst
x1,t
2
qst
x1,t +qst
x,t
2+lst
x,t
2
qst
x,t +qst
x+1,t
2(4)
=βst lst
x1,t
2
qx1,t +qx,t
2+lst
x,t
2
qx,t +qx+1,t
2!
because of (3), where the mortality probabilities are defined in (1) and the state factors βstare
to be defined. (For x= 0 we set qst
1,t =qst
0,t , and lst
1,t =lst
0,t+1 if available, and lst
1,t =lst
0,t else.)
5
Analogous formulas lead to EDst
y,t . Finally summation gives the total expected number of deaths
EDst
t=
100
X
x=0
EDst
x,t +
100
X
y=0
EDst
y,t =βstst
t
in year t. If the year tis a leap year, we add an additional day by multiplying the result by 366
365 .
Observe that the numbers st
tare given by the life table 2017/19 of the German Federal
Statistical Office and by the population tables lst
x,t, lst
y,t . We define the state factors βstas the
solution of the linear regression
minimize
16
X
=1
2019
X
t=2012
wt,ℓ ˆ
dst
tβstst
t2(5)
where ˆ
dst
tare the observed total number of deaths in state stin years t. We have chosen 2012 as
the starting year because end of 2011 the German Federal Statistical Office evaluated and changed
the method of calculating the mortality probabilities and the population tables. The weights wt,ℓ
should equal the reciprocal of the variance of the number of deaths ˆ
dst
t. The number of deaths
is according to (4) a sum of binomially distributed independent random variables Dbin(n, p)
with parameters n=1
2lst
x,t and p=1
2(qst
x,t +qst
x+1,t). Because the mortality probabilities are close
to zero, VD=np(1 p)np =ED, hence we put
wt,ℓ =1
ˆ
dst
t
1
VDst
t
.(6)
Taking partial derivatives in (5) leads to the linear equations
2
2019
X
t=2012
1
ˆ
dst
t
(ˆ
dst
tβstst
t)∆st
t= 0 (7)
yielding βstfor = 1,...,16.
Finally we slightly modify this approach: the method does not take care of the already cal-
culated expected total number of deaths EDtfor the whole of Germany in the pandemic years
stated in Table 2. Clearly, Pst
t=EDt, i.e. the sum of the not adjusted expected deaths in all
states equals the expected number of deaths in Germany, and distributing the expected number
of deaths 2020–2023 according to the method proposed in [20, Table 1 and 2] onto the pandemic
years Pt,t= 1,2,3, one has Pst
Pi=EDPi. But the obtained minimizers are not additive in the
sense that also Pβstst
Piwould still equal EDPi. To take care of this, we fix i {1,2,3}, and
optimize 5 under the constraint in βstthat
16
X
=1
EDst
Pi=
16
X
=1
βstst
Pi=EDPi.
From a mathematical point of view we introduce a Lagrange multiplier and minimize
16
X
=1
2019
X
t=2012
1
ˆ
dst
tˆ
dst
tβstst
t2λ 16
X
=1
βstst
PiEDPi!.
This results in the state factors βst
Pigiven in Table 3, which depend in principle on the pandemic
year, but in fact turn out to be nearly independent of Pi: the maximal difference between βst
Pifor
i= 1,2,3 is 0.00018. Hence from now on for the ease of notation we write βstinstead of βst
Pi.
6
Table 3: State factors βstfor the German states
state βst
Baden-W¨urttemberg 0.922
Bavaria 0.961
Berlin 0.986
Brandenburg 1.036
Bremen 1.024
Hamburg 0.968
Hesse 0.970
Mecklenburg-Vorpommern 1.074
Lower Saxony 1.025
North Rhine-Westphalia 1.030
Rhineland-Palatinate 1.008
Saarland 1.081
Saxony 0.995
Saxony-Anhalt 1.112
Schleswig-Holstein 1.021
Thuringia 1.062
We demonstrate the effect of this state factors for the two extreme cases Baden-W¨urttemberg
and Saxony-Anhalt. Figure 2 shows for the prepandemic years 2012-2019 the unadjusted estimated
excess deaths ˆ
dst
t−△st
tbased on the German-wide mortality probabilities of the life table 2017/19,
and the estimated excess deaths ˆ
dst
tEDst
twhen the estimates are adjusted for the federal-state
specific deviations in mortality probability using the state factors.
Figure 2: Illustration of the problem of using Germany-wide mortality probabilities of the life table
2017/19 for the estimations of the state-specific excess mortalities using the data form the federal
states of Baden-W¨urttemberg and Saxony-Anhalt that deviate most strongly from the Germany-
wide mortality probabilities. The blue dots show the number of estimated excess deaths based on
the German-wide mortality probabilities of the life table 2017/19, the red dots show the number
of estimated excess deaths when the estimates are adjusted for the state-specific deviations in
mortality probability using the state factors.
The state factors derived in this way finally allow us to compute the expected number of deaths
EDst
Pifor each state, and by comparison to the observed number of deaths, the absolute excess
mortality dst
PiEDst
Piand the relative excess mortality (dst
PiEDst
Pi)/EDst
Piin each federal state for
7
the first (04/2020–03/2021), second (04/2021–03/2022), and third (04(2022–03/2023) pandemic
year.
It is illuminating to calculate the correlations between the state factors and the other state-
specific quantities examined in this study (for a description, see below). The state factors are
strongly correlated with mean age (r= 0.76, p < 0.001), proportions of people in peed of care
(r= 0.80, p < 0.001), and the Gross Domestic Product (GDP) which represents a measure of
the wealth of a federal state (r=0.67, p = 0.005). That is, compared to the German-wide
mortality probability reported in the Life Tables, federal states with a higher average age, a
higher proportion of people in need of care, and lower wealth as measured by the GDP show
higher mortality probabilities. The three quantities that correlated with the state factors were
also highly correlated with each other as well (mean age/proportion of people in need of care:
r= 0.85, p < 0.001; mean age/GDP: r=0.88, p < 0.001; proportion of people in need of
care/GDP: r=0.76, p < 0.001). The state factors were uncorrelated with all COVID-19 related
quantities (excess mortality: all p > 0.159; COVID-19 deaths: all p > 0.481; COVID-19 infections:
all p > 0.458; COVID-19 measures: all p > 0.566; COVID-19 vaccination rates: all p > 0.877).
2.3 Correlational Analysis
In order to investigate which state-specific quantities covary with the excess mortality observed in
a federal state, several key quantities were collected, which are described below. All of the data
used in the present study can be downloaded from https://osf.io/xg8eu/.
2.3.1 Number of COVID-19 deaths
The monthly number of COVID-19 deaths for each German federal state is reported by the Robert
Koch Institute. For data security reasons, numbers below four are only states as <4”. In such
cases, the value was set to two. For a few federal states no values were reported during a few
summer month in 2020. In such cases, the value was set to zero based on the assumption that
no COVID-19 deaths occurred in these months. To achieve comparability of the values despite
the different population sizes of the different federal states, the number of COVID-19 deaths
reported for a federal state was standardized based on the expected number of deaths estimated
for a federal state. That is, we determined for each federal state the percentage of the number
of reported COVID-19 deaths relative to the number of expected all-cause deaths. These values
reflect the extent to which COVID deaths have occurred in a federal state in relation to the usually
expected number of deaths from all other causes of death.
2.3.2 Number of COVID-19 infections
The cumulative number of COVID-19 infections for each Germany federal state was daily reported
by the Robert Koch Institute. To examine the relationship with excess mortality, the cumulative
number of COVID-19 infections reported at the end of each of the three pandemic years were
retrieved. To achieve comparability of the values despite the different population sizes of the
different federal states, the cumulative number of reported COVID-19 infections was divided by
the yearly total population of a federal state.
2.3.3 Strength of Measures Taken Against COVID-19
In Germany, the containment measures were determined at the level of the individual federal
states, so that the intensity of the measures taken varies between individual federal states. Which
measures have been imposed over time was recorded on a daily basis by the Federal Ministry for
Economic Affairs and Climate on a so-called Corona data platform [17]. The measures imposed in
a federal state are summarized in a Corona Severity Index (CSI) that provides information about
8
the dynamics and severity of the imposed measures. The calculation of the CSI is methodically
based on the Oxford Stringency Index, that is, the imposed measures are evaluated according to
several categories and summed up based on a point system that ranges from zero (no measures at
all) to 100 (maximal strength). To determine the strength of imposed measures in a federal state
in a pandemic year, the mean across the monthly Corona Severity Index was calculated.
2.3.4 Vaccination Rates
The percentage of people vaccinated (first vaccinations, second vaccinations, third vaccinations) in
each of the German federal states was daily reported by the Robert Koch Institute. To examine the
relationship with excess mortality, the vaccination rates reported at the end of each month during
the three pandemic years were retrieved. In the third pandemic year, the variation in vaccination
rates across the federal states over the months of the pandemic year was extremely stable (rate
of second vaccinations: all r > 0.99; rate of third vaccinations, all r0.96), and the variation in
vaccination rates for second and third vaccinations was highly similar as well (April 2022: r= 0.82;
since June 2022: all rs > 0.88). In the second pandemic year, the variation in vaccination rates
across the federal states over the months of the pandemic year reached extremely stable values as
well (rate of second vaccinations: since August 2021: all r > 0.99; rate of third vaccinations: since
January 2022: all r > 0.98, and the variation in vaccination rates for second and third vaccinations
reached highly similar levels as well (April 2022: r= 0.82; since June 2022: all r > 0.88). Due to
this highly similar pattern in vaccination rates across time and types of vaccination, we decided
to use the percentage of triple vaccinated people at the end of a pandemic year as an indicator for
the vaccination rate in a federal state, and to report the correlations between excess mortality and
the monthly rates of double and triple vaccinated people in the appendix.
2.3.5 Gross Domestic Product
The Gross Domestic Product represents a measure of the wealth of a federal state which is in
Germany provided in a joint statistics portal of the statistical offices of the federal states [28]. To
control for differences in population sizes, the GDP per capita was used which shows a federal
state’s GDP divided by its total population. The variations in the GDPs per capita across the
federal states in the years 2020, 2021, and 2022 were extremely similar (all r > 0.99). Due to
this extremely similar pattern across time, we decided to use the mean GDP per capita across the
years 2020 to 2022.
2.3.6 Poverty Rate
To measure poverty in Germany, the German Federal Statistical Office determines the rate of
people that are below the poverty risk threshold (i.e., the at-risk-of-poverty rate) for each of the
federal states [29]. According to this measurement, people who have less than 60% of the median
income of the population are considered to be at risk of poverty. The variations in the at-risk-of-
poverty rates across the federal states in the years 2020, 2021, and 2022 were extremely similar
(all r > 0.96). Due to this extremely similar pattern across time, we decided to use the mean
at-risk-of-poverty rate across the years 2020 to 2022.
2.3.7 Mean Age
The mean age of the population of a federal state for the three pandemic years was calculated based
on the age-dependent population size data provided by the German Federal Statistical Office for
each year. The variations in mean age across the federal states in the years 2020, 2021, and 2022
were extremely similar (all r > 0.99). Due to this extremely similar pattern across time, we decided
to use the mean age across the years 2020 to 2022.
9
2.3.8 Proportions of People in Need of Care
The proportions of people in need of care in a federal state is provided by the German Federal
Statistical Office [11]. The most current data corresponds to the status as of December 31, 2021,
and we have used this data.
3 Results
3.1 Excess Mortality in German States
Using the state factors derived in Section 2.2.1, we compute the expected number of deaths for
each of the German states st,= 1,...,16, for the three pandemic years Pi,i= 1,2,3 and
compare them in Table 4 to the observed values ˆ
dst
Pi.
Table 4: Expected and observed number of deaths in 16 German states
04/20–03/21 04/21–03/22 04/22–03/23
state exp. obs. exp. obs. exp. obs.
Baden-W¨urttemberg 115,231 116,463 116,699 119,701 118,010 126,401
Bavaria 140,645 145,234 142,187 147,897 143,453 153,615
Berlin 37,078 38,671 37,302 37,541 37,676 39,660
Brandenburg 34,500 36,223 35,120 36,555 35,597 37,739
Bremen 8,061 8,082 8,112 8,290 8,106 8,999
Hamburg 18,337 18,607 18,482 18,881 18,583 20,016
Hesse 69,356 72,041 70,061 71,297 70,626 76,237
Mecklenburg-Vorpommern 22,787 22,519 23,272 24,418 23,556 25,206
Lower Saxony 98,431 97,408 99,760 100,318 100,797 110,388
North Rhine-Westphalia 215,195 216,122 217,136 221,380 218,411 237,229
Rhineland-Palatinate 49,619 49,568 50,157 50,967 50,543 54,225
Saarland 13,835 13,890 13,949 14,414 13,999 15,519
Saxony 57,330 65,674 57,365 60,999 57,528 60,981
Saxony-Anhalt 34,029 35,745 34,291 36,136 34,352 37,235
Schleswig-Holstein 36,647 35,610 37,405 37,025 37,998 41,298
Thuringia 30,576 32,204 30,829 33,281 30,865 33,136
total 981,656 1,004,061 992,127 1,019,100 1,000,102 1,077,884
The sum of all states in the last row clearly equals the numbers for Germany stated already in
Table 2. Note that the observed number of deaths in 2023 and thus also in the last three months
of P3is still preliminary.
The excess mortality is the difference between the observed values and the expected values
ˆ
dst
PiEDst
Pi.
We also state in Table 5 the relative excess mortality
ˆ
dst
PiEDst
Pi
EDst
Pi
.
10
Table 5: Relative excess mortality in 16 German states
state 04/20–03/21 04/21–03/22 04/22–03/23
Baden-W¨urttemberg 1.07% 2.57% 7.11%
Bavaria 3.26% 4.02% 7.08%
Berlin 4.29% 0.64% 5.27%
Brandenburg 4.99% 4.09% 6.02%
Bremen 0.26% 2.19% 11.02%
Hamburg 1.48% 2.16% 7.71%
Hesse 3.87% 1.76% 7.94%
Mecklenburg-Vorpommern -1.17% 4.92% 7.00%
Lower Saxony -1.04% 0.56% 9.51%
North Rhine-Westphalia 0.43% 1.95% 8.62%
Rhineland-Palatinate -0.10% 1.62% 7.28%
Saarland 0.40% 3.34% 10.86%
Saxony 14.56% 6.34% 6.00%
Saxony-Anhalt 5.04% 5.38% 8.39%
Schleswig-Holstein -2.83% -1.02% 8.68%
Thuringia 5.32% 7.95% 7.36%
3.2 Correlation Matrix
Table 6 shows the correlations between excess mortality and the reported number of COVID-19
deaths and COVID-19 infections, the strength of the measures, the vaccination rates, the GDP,
the poverty rate, the mean age, and the proportion of people in need of care.
Table 6: Correlation matrix
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
1. Excess Mortality: Year 1
2. Excess Mortality: Year 2 .63**
3. Excess Mortality: Year 3 -.52* -.25
4. COVID-19 Deaths: Year 1 .96** .63** -.56*
5. COVID-19 Deaths: Year 2 .78** .89** -.37 .84**
6. COVID-19 Deaths: Year 3 -.18 -.09 .32 -.06 .02
7. COVID-19 Infec%ons: Year 1 .90** .58* -.41 .94** .77** -.03
8. COVID-19 Infec%ons: Year 2 .70** .82** -.43 .69** .78** -.12 .67**
9. COVID-19 Infec%ons: Year 3 -.72** -.63** .71** -.74** -.70** .36 -.72** -.64**
10. Strength of Measures: Year 1 .17 .05 .10 .27 .15 .09 .24 .20 .06
11. Strength of Measures: Year 2 .10 .25 -.16 .03 .07 -.17 -.06 .19 -.32 -.16
12. Strength of Measures: Year 3 -.09 -.07 -.11 -.06 -.16 .15 -.17 -.10 .01 -.14 .32
13. Vaccina%on Rate: Year 2 -.80** -.78** .67** -.81** -.80** .16 -.70** -.80** .74** -.17 -.24 .04
14. Vaccina%on Rate: Year 3 -.82** -.81** .65** -.81** -.85** .30 -.68** -.79** .74** -.13 -.15 .10 .96**
15. Gross Domes%c Product -.19 -.39 .11 -.09 -.24 .56* .01 -.17 .16 .00 .12 .09 .23 .41
16. Poverty Rate -.11 -.04 .52* -.26 -.19 -.03 -.08 -.32 .08 -.40 .21 -.17 .26 .28 .11
17. Mean Age .28 .65** -.03 .19 .46 -.36 .04 .37 -.21 .06 .15 .08 -.37 -.52* -.88** -.10
18. People in Need of Care .32 .63** .12 .21 .44 -.17 .16 .26 -.18 -.12 .07 .06 -.36 -.43 -.76** .26 .85**
Note. ** p < .01; * p < .05; N = 16
In this section, we only point out the observed main correlative patterns, which will be discussed
in detail in the following discussion section. Two correlation patterns stand out very clearly. The
first correlative pattern concerns the association between excess mortality and COVID-19-related
factors. In the first and second pandemic year, the excess mortality observed in an federal state
is highly correlated with the reported number of COVID-19 deaths (first pandemic year: r=
0.96, p < 0.001; second pandemic year: r= 0.89, p < 0.001) and the reported number of COVID-19
infections (first pandemic year: r= 0.90, p < 0.001; second pandemic year: r= 0.82, p < 0.001).
This pattern changes in the third pandemic year where the correlation between excess mortality
and the reported number COVID-19 deaths is no longer significant (r= 0.32, p = 0.23), while
11
the correlation between excess mortality and the reported number COVID-19 infections remains
significant (r= 0.71, p = 0.002).
The second correlation pattern that stands out concerns the association between vaccination
rates and excess mortality as well as the number of COVID-19 deaths and COVID-19 infections.
The vaccination rate in a federal state in the second pandemic year is highly negatively correlated
with the excess mortality and the reported number of COVID-19 deaths and COVID-19 infections,
both in the first pandemic year (excess mortality: r=0.80, p < 0.001; COVID-19 deaths:
r=0.81, p < 0.001; COVID-19 infections: r=0.70, p = 0.002) and the second pandemic year
(excess mortality: r=0.78, p < 0.001; COVID-19 deaths: r=0.80, p < 0.001; COVID-19
infections: r=0.80, p < 0.001). In the third pandemic year, this pattern changes fundamentally.
The vaccination rate in a federal state in the third pandemic year is now positively correlated with
the excess mortality and the reported number of COVID-19 deaths and COVID-19 infections
(excess mortality: r= 0.65, p = 0.006; COVID-19 deaths: r= 0.30, p = 0.254; COVID-19
infections: r= 0.74, p = 0.001).
With regard to all other correlations, no pattern can be recognized; only a few smaller and
time-limited correlations can be observed. Excess mortality in the second pandemic year correlates
moderately with mean age (r= 0.65, p = 0.006) and the proportion of people in need of care
(r= 0.63, p = 0.009), two variables that are highly correlated by themselves (r= 0.85, p = 0.001).
In the third pandemic year, excess mortality correlates moderately with the poverty rate (r=
0.52, p = 0.041), and the reported number of COVID-19 deaths correlates moderately with the
GDP (r= 0.56, p = 0.024). Due to the high number of correlations examined and the moderate
size and unsystematic occurrence of these correlations, it can be assumed that these are probably
correlations that become significant by chance and do not reflect true effects.
4 Discussion
The aim of the present study was to estimate excess mortality in the individual German federal
states using scientifically sound methods, and to explore the relationship between excess mortality
and several key state-specific quantities. The estimations of excess mortality based on the state-of-
the-art method of actuarial science (Kuhbandner and Reitzner [9]) revealed that excess mortality
substantially varied across the federal states in Germany, ranging from -2.83% to 14.56% in the
first pandemic year (04/20 03/21), -1.02% to 7.95% in the second pandemic year (04/21 03/22),
and 5.27% to 11.02% in the third pandemic year (04/22 03/23).
4.1 COVID-19 related correlations
Regarding possible explanations of the variation of excess mortality across federal states, the
correlation analysis showed that in the first two pandemic years excess mortality observed in a
federal state was strongly correlated with the reported numbers of COVID-19 deaths and infections:
the higher the relative number of reported COVID-19 deaths and infections, the higher the relative
excess mortality (for an illustration, see Figure 3A). Such a correlational pattern clearly suggests
that the variation of excess mortality across federal states may stem from the fact that different
federal states were affected to different extent by COVID-19.
As can clearly be seen in Figure 3A, the reported number of COVID-19 deaths largely exceeds
the observed amount of excess mortality in both the first and the second pandemic year. If the
reported number of COVID deaths matched the observed excess mortality, the data points for the
federal states should move along the dashed line. However, in the first and second pandemic year,
the data points are instead consistently well above the dashed line, which means that, relative to
the number of expected deaths, the reported number of COVID deaths was substantially higher
than the number of excess deaths.
12
Figure 3: COVID-19 related correlation results. (A) shows the relationship between the
relative excess mortality and the relative number of COVID-19 deaths (in relation to the number
of expected deaths) for each federal state in the first (blue dots), second (orange dots), and third
(red dots) pandemic years. The dashed line indicates what would be the case if the reported
number of COVID-19 deaths exactly matched the number of observed excess deaths. (B) shows
the total number of expected deaths (blue bars), the total number of reported COVID-19 deaths
(orange bars), and the total number of reported Non-COVID deaths (red bars), and (C) shows
the total number of excess deaths (red bars) and the total number of reported COVID-19 deaths
(orange bars) across all federal states in the three pandemic years.
This observation is illustrated in Figure 3B in more detail where the total numbers of expected
deaths, reported COVID-19 deaths, and reported Non-COVID deaths across all federal states is
shown. In the first pandemic year, 981,656 deaths were expected but 1,004,061 deaths observed,
meaning there were 22,405 more deaths observed than expected. However, at the same time,
78,185 COVID-19 deaths were reported. That is, the number of reported COVID-19 deaths was
3.5 times higher than the number of observed excess deaths, and the number of reported Non-
COVID-deaths was 0.94 times lower than the number of expected deaths. In the second pandemic
year, 992,127 deaths were expected but 1,019,100 deaths observed, meaning there were 26,973
more deaths observed than expected. However, at the same time, 53,883 COVID-19 deaths were
reported. That is, the number of reported COVID-19 deaths was 2.0 times higher than the number
of observed excess deaths, and the number of reported Non-COVID-deaths was 0.97 times lower
than the number of expected deaths.
This surprising pattern may have occurred due to two possible reasons. First, it could be
that the measures taken against COVID-19 have reduced the number of Non-COVID deaths, and
that the reported COVID-19 deaths are all true excess deaths. However, this possibility is highly
13
unlikely given the observed correlations between the decline in Non-COVID deaths observed in a
federal state and the strength of the measures taken. In the first pandemic year, a zero correlation
is observed (r= 0.06, p = 0.823), and in the second pandemic year, even a tendentially negative
correlation is observed (r=0.38, p = 0.152), that is, the stronger the measures taken, the smaller
the decline in the number of observed Non-COVID deaths.
It is therefore more likely that the second possibility is the case: Obviously, COVID-19 has
replaced other commonly occurring causes of death. One possible mechanism may be that the
spread of to the SARS-CoV-2 virus has inhibited the viral reproduction of other common viruses,
a phenomenon called viral interference, which has been assumed to occur for the SARS-CoV-2 virus
(Deleveaux et al. [7]). Consistent with such a hypothesis, a global decline in influenza was observed
during the first two pandemic years (Bonacina [3]), which resulted in the elimination of an usually
occurring cause of death. Another possible mechanism may be an inflationary use of the diagnosis
“COVID-19 death”. Since the diagnosis “COVID-19 death” is mainly based on the presence of a
current positive SARS-CoV-2 PCR test, such a diagnosis does not clearly specify whether a death
reported as “COVID-19 deaths” was indeed caused by a SARS-CoV-2 infection or whether the
deceased person died from some other cause of death with a coincidentally occurring SARS-CoV-2
infection. Accordingly, it may be that a larger proportion of deaths reported as ”COVID-19 death”
actually died from other causes of death, a hypothesis which is indeed supported by autopsy studies
(e.g., von Stillfried [33]).
Regardless of which of the two possibilities is primarily responsible for the observed pattern, in
both cases this would mean that the reported number of COVID-19 deaths significantly overestim-
ates the burden of COVID-19 on mortality, and that the true excess mortality caused by COVID-19
would be on the same scale as previous strong flu waves, such as the flu season 2017/2018 where
it is estimated that 25,100 people in Germany died due to influenza (Robert Koch-Institute [25]).
Taken together, the picture that is suggested by the COVID-19-related findings for the first and
second pandemic years is that the excess mortality observed was very likely driven by COVID-19.
However, the observed excess mortality is in both years in the range of the excess mortality usually
observed during strong flu waves, which would mean that COVID-19 was not an extraordinary
pandemic, at least in Germany.
This picture changes fundamentally in the third year of the pandemic. As can be seen in Figure
3A, suddenly the correlation between excess mortality and the reported number of COVID-19
deaths largely disappears, and suddenly the number of excess deaths largely exceeds the reported
number of COVID-19 deaths. As can be seen in Figure 3B, in the third pandemic year, 1,000,102
deaths were expected but 1,077,884 deaths observed, meaning there were 77,782 more deaths
observed than expected. However, at the same time, only 38,062 COVID-19 deaths were reported.
That is, the number of reported COVID-19 deaths was only less than half the number of excess
deaths, and the number of reported Non-COVID-deaths was 1.04 times higher than the number
of expected deaths.
The same pattern was observed in every single federal state. In all but one of the federal states
(Saxony), excess mortality increased from the first to the third year of the pandemic, while in all
but one (Lower Saxony) COVID-19 deaths decreased. However, the same pattern emerged in both
exceptional federal states. In Saxony, COVID-19 deaths decreased more than excess mortality,
and in Lower Saxony, excess mortality increased more than COVID deaths.
Taken together, the picture that is suggested by the COVID-19-related findings for the third
pandemic year is that there was an exceptionally high excess mortality far above the usual level
during strong flu waves, which can hardly be explained by COVID-19 but must be due to other
factors.
Finally, a closer look at the pattern observed in the first and second pandemic years suggests
that it is already becoming apparent in the second pandemic year that an additional factor is
beginning to contribute to excess mortality. A striking observation is that excess mortality and
the reported number of COVID-19 deaths develop in opposite directions from the first to the second
14
year of the pandemic. Although the number of reported COVID deaths decreases by 24,302, the
number of excess deaths increases by 4,568. This contrasting developmental pattern makes it
unlikely that the excess mortality observed in the second pandemic year can be fully explained
by COVID-19. Rather, this finding suggests that a second non-COVID-related factor appears to
increasingly determine excess mortality.
4.2 Vaccination-related Correlations
The second striking correlation pattern are the high correlations between vaccination rate, excess
mortality and the reported number of COVID-19 deaths and infections of a federal state (for an
illustration, see Figure 4).
Figure 4: Vaccination-related correlations. The relationship between vaccination rate in a
federal state and (A) excess mortality, (B) the reported number of COVID-19 deaths relative to
the number of expected deaths, and (C) the reported number of SARS-CoV-2 infections relative
to the population size is shown in the first, second, and third pandemic year.
In a previous study (Thum [32]), it was reported that the excess mortality observed in a federal
state in the second half of 2021 was negatively correlated with the COVID-19 vaccination rate in
a federal state. The present findings replicate and extend this finding by showing that in the
second pandemic year in which large parts of the population were double and triple vaccinated,
both excess mortality and the number of reported COVID-19 deaths and infections were negatively
correlated with the vaccination rate of a federal state.
At first glance, one is tempted to interpret this finding as evidence of the effectiveness of the
15
vaccinations, as various media did with regard to the findings of the previous study by Thum.
However, the fact that the vaccination rate in the second pandemic year is also correlated to
exactly the same extent with the excess mortality and the reported number of COVID-19 deaths
and infections in the first pandemic year where hardly anyone was vaccinated the rate of fully
vaccinated persons in Germany was 0.5% at the end of January 2021, 2.5% at the end of February
2021 and 4.9% at the end of March 2021 speak against such an interpretation. Rather, this
indicates that the negative correlation between vaccination rate and excess mortality and the
reported number of COVID-19 deaths and infections observed in the second pandemic year is due
to the effect of a third variable.
The negative correlation between the vaccinations administered in the second pandemic year
and the reported numbers of COVID-19 deaths and infections in the first pandemic year indicate
an interesting fact: Apparently, the less a federal state was affected by COVID-19 in the first
pandemic year, the more people were vaccinated in the second pandemic year. At the same time,
there is a strong correlation between the reported numbers of COVID-19 deaths and infections
in the first and second pandemic year, indicating that the extent of being affected by COVID-19
was highly stable across federal states from the first to the second pandemic year. Taken together,
this pattern clearly suggests that the negative correlation between vaccination rate and excess
mortality and the reported numbers of COVID-19 deaths and infections does not reflect a causal
effect of the vaccinations. Instead, this correlation seems to stem from the fact that vaccination
rates were highest in the federal states that were least affected by COVID-19.
The fact that the size of the negative correlation between vaccination rate and excess mortality
and the reported number of COVID-19 deaths did not increase in size from the first to the second
pandemic year rather suggests that the vaccinations had no beneficial effect. If the vaccinations
were effective, the federal states with the highest vaccination rates would have benefited the most,
which means that the correlations between vaccinations and mortality observed in the first year of
the pandemic should have been even more negative in the second year of the pandemic, which is
not the case.
This is further supported by an analysis of the increase in excess mortality from the first to
the second year of the pandemic. Figure 5 shows the increase in excess mortality from the first to
the second and third pandemic years in percentage points.
Figure 5: Increase in Excess Mortality and Vaccinations. The increase in excess mortality
from the first to the second and third pandemic years in percentage points in the individual federal
states is shown as a function of the vaccination rate in a federal state.
The most obvious expectation of an effective vaccination would be that the increase in excess
mortality would be lowest in the federal states in which the most vaccinations were administered.
However, the opposite is the case. Already in the second pandemic year, a moderately strong
positive correlation is observed (r= 0.45, p = 0.081), and in the third pandemic year, a strong
correlation is observed (r= 0.85, p < 0.001), indicating that the increase in excess mortality is
16
the higher the higher the vaccination rate. Importantly, as can be seen in Figure 5, a continuous
increase in excess mortality with increased vaccination rates can be observed even in the middle
range of the observed vaccination rates, which rules out that the observed correlations could be
driven by the extreme values.
The impression that the negative relationship between the vaccinations and excess mortality
increases from the second to the third pandemic year is further supported when we look at the
correlations between vaccination rate and excess mortality and COVID-19 deaths and infections
in the third year of the pandemic. As can be seen in the Figure 4 above, the correlation pattern
fundamentally changes from the second to the third pandemic year. Now, positive correlations are
observed between vaccination rate and excess mortality and the reported number of COVID-19
deaths and infections: The higher the vaccination rate, the higher the observed excess mortality
and the reported number of COVID-19 deaths and infections. This is exactly the opposite of what
one would expect from an effective vaccination: as the vaccination rate increases, the number of
infections increase as well as the number of infection-related deaths and the overall number of
deaths.
The observation that excess mortality and the reported number of COVID-19 deaths and in-
fections in the third year of the pandemic are the higher the more people have been vaccinated
in a federal state is an irrefutable empirical fact. Such a pattern would be expected if the vaccin-
ations had caused negative effects instead of positive effects. However, since this is a correlative
relationship, this observation does not necessarily mean that the observed differences in mortality
between federal states can be causally attributed to the different vaccination rates. Due to this
fact, it is important to explore various possibilities how such a correlative pattern as observed in
the third year of the pandemic could arise, even though the vaccinations did not have any negative
effects or still positive effects. This will be done next.
The negative correlations observed in the second year of the pandemic can be attributed to
the third variable that vaccinations were highest in the federal states that were least affected
by COVID-19 in the first pandemic year. Thus, the question arises whether this can possibly
also explain the positive correlations observed in the third year of the pandemic. Already the
fact that the correlations between vaccinations and excess mortality and the reported number of
COVID-19 deaths and infections change from the second to the third pandemic year from negative
to positive makes this seem unlikely. If the fact that vaccinations were highest in the federal
states that were least affected by COVID-19 in the first pandemic year were to represent a third
variable explanation for the positive correlations observed in the third pandemic year, another
factor beyond the vaccinations must have suddenly appeared.
Finding such a possible factor is difficult. One factor could perhaps be that the more people
have already been affected by COVID-19, the smaller the number of people susceptible to COVID-
19, which would mean that the initially more severely affected federal states are increasingly less
affected. First, it is important to note that vaccinations are being administered with the aim of
reducing the number of people susceptible to COVID-19. This means that an effective vaccination
would actually reduce the number of susceptible people and thus cancel out the effect of such a
third variable. If such a third variable were to explain the observed positive correlations between
vaccinations and mortality, it would mean that the positive correlations are not due to a negative
effect of the vaccinations, but at the same to time this would mean that the vaccinations did not
produce positive effects.
However, the possibility that such a third variable might explain the positive correlation
between vaccinations and excess mortality is anyway unlikely due to at least two reasons. First, if
this third-variable explanation were true, then the transition from negative to positive correlations
should be gradual. However, the observed pattern corresponds to a sudden change: correlations of
exactly the same size are observed in the first and second pandemic year, and then the correlations
suddenly jump in the exact opposite direction in the third pandemic year. Second, when statistic-
ally controlling for the possible third variable of the extent of being affected by excess mortality in
17
the first two pandemic years (sum of excess mortality across the first and second pandemic year),
the positive correlation between vaccination rate and excess mortality does not change (partial
r= 0.60, p = 0.018).
Another theoretical possibility is that the vaccinations might have been effective and prevented
deaths and infections despite the positive correlations between vaccination rate and excess mor-
tality and the reported number of COVID-19 deaths and infections. That is, although mortality
and the incidence of COVID-19 were highest in the federal states with the highest vaccination
rates, without the vaccinations, the excess mortality and incidence of COVID-19 might still have
been substantially higher in these federal states. This is unlikely, because if that were the case,
an additional factor beyond the vaccinations must have suddenly emerged from the second to the
third pandemic year that hit precisely those federal states that until then had only been slightly
affected by COVID-19. Furthermore, this possibility is also unlikely given the fact that the ob-
served mortality and infection rates in the most heavily vaccinated federal states were already so
high that not much room is left for such an explanation. That is, if the vaccinations were to be
effective despite the observed high mortality and infection rates, unrealistically high mortality and
infection rates would have to be assumed.
The observed correlation pattern reflects a spatial effect: the highest excess mortality was
observed in the most vaccinated regions. As shown in our recent study (Kuhbandner and Reitzner
[20]), a similar relationship between vaccinations and excess mortality is observed on the temporal
level. In the second pandemic year, during the months with a high number of vaccinations, also a
high number of excess deaths was observed, a relationship which is especially pronounced for the
third vaccinations. After the third vaccinations were completed, excess mortality began to rise
continuously in the third year of the pandemic, reaching a maximum of 28% in December 2022.
The fact that particularly high excess mortality occurs both in regions and in time windows in
which many vaccinations took place strengthen the empirical evidence that the vaccinations may
have had a negative effect instead of a positive effect.
To summarize, from a statistical perspective, the observed pattern is as follows: In the first
year of the pandemic, there is a very strong correlation between excess mortality and the reported
number of COVID-19 deaths, suggesting a causal connection between excess mortality and COVID-
19. However, the reported number of COVID deaths greatly overestimates the excess mortality
that has occurred, which is in line with strong flu waves in previous years. In the second year of
the pandemic, a new excess mortality factor suddenly appears, which is reflected in the fact that
the reported number of COVID-19 deaths decreases, but excess mortality increases. The fact that
the increase in excess mortality in the second year of the pandemic is correlated both temporally
and spatially with the number of vaccinations administered suggests that this new excess mortality
factor could be the vaccinations. This hypothesis is further strengthened empirically by the fact
that a highly positive correlation between vaccination rate and excess mortality is observed in the
third pandemic year, suggesting a long-lasting negative effect of the vaccinations.
4.2.1 Possible Third-Variable Explanations
The results of the correlation analysis show a very clear and simple picture: There are only two
variables that are systematically related to excess mortality: COVID-19 and the vaccination rate.
The fact that the vaccination rate in the second year of the pandemic is already highly negatively
correlated with excess mortality as well as with the reported number of COVID-19 deaths and
infections in the first year of the pandemic clearly shows that the less a federal state was affected
by COVID in the first pandemic year, the more vaccinations were administered. The fact that
this negative correlation suddenly reverses in the third year of the pandemic clearly shows that a
new factor must have suddenly emerged that drove up excess mortality and the number of COVID
deaths and infections in the federal states that were initially least affected by COVID-19.
The fact that the vaccination rate is the only variable that is positively correlated with excess
18
mortality as well as with the number of COVID-19 deaths and infections in the third pandemic
year makes it seem very likely that this new factor was the COVID-19 vaccination. Further
empirical evidence for such an interpretation is the analysis in which difference values with regard
to the increase from the first to the second and third pandemic years are considered, whereby
all time-stable state-specific third variables are controlled. The correlation between vaccinations
and excess mortality remains intact when the state-specific burden of COVID-19 in the first two
pandemic years is statistically controlled, this proves that the initial burden of COVID-19 is not a
third variable that could explain the relationships between excess mortality and vaccinations. The
fact that no systematic correlations are observed with regard to the other explored state-specific
quantities excludes these as possible third variables as well.
Of course, although the correlation analysis provides a clear picture, it is still possible that
there is still a hidden third variable responsible for the increase in excess mortality that is only
randomly correlated with vaccinations. However, this third variable would have to meet a number
of specifications: It would have to appear suddenly in the course of the second year of the pandemic
and happen to have the greatest impact on precisely those federal states that have so far been
least affected by COVID-19. In addition, this third variable would have to have had its strongest
effect at precisely the times when vaccination was most widespread. Finding such a variable seems
difficult.
4.2.2 Previous Vaccine Effectiveness Studies
While the fact that there are strong positive correlations between vaccinations and mortality that
cannot easily be ruled out by third variables provide correlative evidence that the effect of the
COVID-19 vaccinations on mortality is negative rather than positive, it is important to emphasize
that such a conclusion is drawn from a statistical perspective and not from the perspective of the
existing medical literature about the effectiveness of the COVID-19 vaccinations. In fact, from
the perspective of the existing medical studies on vaccine effectiveness, the observed correlation
pattern is highly surprising. For instance, according to a large meta-analysis covering the period
up to the end of December 2022, across all SARS-CoV-2 strains, vaccine effectiveness directly after
vaccination was 91% for mortality, with a slight decline to 86% in the long run (Wu et al. [34]).
However, the observed empirical correlations between vaccinations and excess mortality make it
seem almost impossible that the vaccine effectiveness estimated in the medical studies could reflect
the true effect of the vaccinations. Since in the federal states with the highest vaccination rates
over 97 percent of the population over 60 years of age were at least fully vaccinated, it is almost
impossible that the highest excess mortality is still observed in these federal states if the vaccine
effectiveness was really that high. The only way there could occur a highly positive correlation
between vaccinations and excess mortality despite a high effectiveness of the vaccinations would be
if side effects outweigh the positive effects of the vaccinations. However, this is unlikely because the
vaccination rate is not only positively correlated with excess mortality but also with the reported
numbers of COVID-19 deaths and infections.
A possible explanation for the divergence between the reported correlation results and the res-
ults of previous vaccine effectiveness studies is that most studies on COVID-19 vaccine effectiveness
are so-called observational studies where subjects are not randomly assigned to a vaccination group
and an unvaccinated control group, but where the fate of people is followed who have decided for or
against vaccination for whatever reasons. Due to the lack of randomization, observational studies
provide less reliable results. If fewer cases of infections or deaths are found among vaccinated
people than among unvaccinated people, this difference does not necessarily have to be due to the
vaccination. It would be conceivable, for example, that people who have decided to be vaccinated
would be more health-conscious overall and therefore perform better. The fact that such distort-
ing effects exist in published observational studies has been shown, for example, by re-analyses of
observational studies on the effect of flu vaccinations (Jefferson [18]). In particular, as reported
19
in a recent study, this problem is compounded by the fact that contemporary observation stud-
ies published in medical journals typically fail to satisfy important quality criteria (Grosman and
Scott [16]).
Interestingly, contrary to the results reported in the observation studies, in the large initial
randomized controlled studies on the effectiveness of the COVID-19 vaccines, no positive effect
of the vaccinations on mortality was observed. In the Pfizer-BioNTech vaccine effectivity study,
for example, during the blinded two-month period, overall one more death was reported in the
placebo group than in the vaccinated group (Thomas et al. [31]). According to the data reported
in the 6-Month Interim Report of Adverse Event, in the group of vaccinated subjects 21 people
died (two of which were unblinded subjects from the original control group that were vaccinated
after the unblinding) whereas in the unvaccinated group only 17 people died (Michels et al. [23]).
This pattern of findings suggests as well rather a negative than a positive effect of vaccinations
on overall mortality, although it cannot be assessed whether the observed differences reflect a true
or just a random effect because of the very small number of reported cases. However, a similar
picture emerges when looking at serious adverse events which occurred more often. As shown in
a re-analysis of the original trial data (Fraiman et al. [14]), statistically significant increases in
serious adverse events were observed in the vaccination group. In particular, the excess risk of
serious adverse events in the vaccination group was for times larger than the risk of COVID-19
hospitalization in the placebo group.
4.3 Strength of measures
It is noteworthy that not a single significant correlation is observed with regard to the strength
of the measures taken in the three pandemic years, neither with excess mortality nor with the
reported number of COVID-19 deaths or the number of SARS-CoV-2 infections. One would have
expected at least some influence on the number of SARS-CoV-2 infections, and in the optimal case
a reduction of the number of COVID-19 deaths and the excess mortality. The fact that not a single
significant correlation was observed in any of the three pandemic years between the measures taken
against COVID-19 and the number of COVID-19 deaths and infections makes it seem unlikely that
the measures taken had any effect but only have produced statistical noise. Such a result is at
first glance unexpected, given that the results of some extensive observational studies apparently
show that at least some of the measures have had positive effects (e.g., Talic et al. [30]). However,
in order to draw valid conclusions from observational studies, numerous possible sources of error
must be excluded (e.g., confounding bias, population bias, spatial and/or temporal dependence
bias, bias due to measurement errors). Critically, this is not done in many studies, as shown, for
instance, in a recent systematic review on the effects of environmental and socioeconomic variables
on the spread of COVID-19 (Barcel´o and Saez [2]). In all of the reviewed observational studies,
to a greater or lesser extent, methodological limitations were detected that prevented the drawing
of valid conclusions. Indeed, methodological problems have even been demonstrated to exist in
studies published in the highest-ranking peer-reviewed journals (Kuhbandner et al. [19]). The
empirical finding that there are no correlations between the strength of the measures taken in a
federal state and the reported number of COVID-19 deaths and infections definitely shows that
there is no simple direct effect, but that additional assumptions must be made in order to determine
potential effects of the measures.
4.4 Stillbirths
In our previous study on excess mortality in Germany (Kuhbandner and Reitzner [20]), additionally
the number of stillbirths was analyzed. The results showed a similar pattern than that observed
for excess mortality: the number of stillbirths in Germany showed a relatively stable course during
the previous years until the start of the vaccination campaign, after which a sudden increase was
20
observed. To determine whether a similarity between excess mortality and stillbirths also exists
at the level of the correlations with the vaccination rate of a federal state, we examined whether
the number of stillbirths also varies as a function of the vaccination rate of a federal state.
The Federal Statistical Office has now published the final data for 2022 at the federal state
level ([12], [13]). Note that the following analyses at the stillbirth level do not refer to pandemic
years as before, but to calendar years, because the stillbirth data at the federal state level is only
published at the annual level. As shown in Figure 6A, indeed also at the level of the correlations
with the vaccination rate of a federal state (rate of second vaccinations at the end of the year in
the age group 18-59; no more precise age breakdown available), the same pattern is observed at
the level of stillbirths as at the level of excess mortality.
Figure 6: Relationship between stillbirths and vaccination rates. (A) shows the relationship
between the vaccination rate in a federal state and the number of stillbirths per 1,000 total births
is shown in the first (2020), second (2021), and third (2022) year during the pandemic. (B) shows
the increase in stillbirths from the first to the second (from 2020 to 2021) and the third (from 2020
to 2022) year during the pandemic in pro mille points in the individual federal states as a function
of the vaccination rate in a federal state.
In 2020, a negative correlation between the number of stillbirths and the vaccination rate in
the subsequent year 2021 is observed (r=0.66, p = 0.007). That is, in the federal states in
which the stillbirth rate was lowest in 2020 before the vaccinations started, most people were
vaccinated the following year 2021. The negative correlation decreases in the year 2021 where
the vaccinations started (r=0.29, p = 0.290) and turns around and becomes positive in 2022
(r= 0.33, p = 0.234).
As shown in Figure 6B, this is further supported by an analysis of the increase in the number of
stillbirths from the first to the second (from 2020 to 2021) and the third (from 2020 to 2022) year
during the pandemic. Already for the increase in the second year, a moderately strong positive
correlation is observed (r= 0.37, p = 0.178), and in the third pandemic year, a strong positive
correlation is observed (r= 0.72, p = 0.002), indicating that the increase in stillbirths was the
higher the higher the vaccination rate. Note that the reported values refer to the federal states
without the smallest federal state of Bremen, because Bremen was a strong outlier in in 2020 and
2022 (in both years stillbirth rate more than three standard deviations above the mean occur);
including Bremen did not change the observed result pattern.
21
5 Conclusion
The present study used the state-of-the-art method of actuarial science to estimate excess mortality
in the federal states of Germany in the three pandemic years (04/2020 to 03/2023). The estim-
ated excess mortality showed substantially variance across the federal states. The exploration of
several key state-specific quantities revealed that only two quantities showed a strong correlational
relationship with the observed excess mortality: COVID-19 deaths and the COVID-19 vaccination
rate. While the excess mortality in the first and second pandemic year was strongly correlated
with the reported number of deaths and infections, in the second and third pandemic years, an
increasingly stronger relationship between excess mortality and the vaccination rate was observed.
Contrary to what would be expected with an effective vaccination, positive instead of negative
correlations were observed: the more vaccinations were administered in a federal state, the greater
the increase in excess mortality. This correlational finding is in line with previous correlational
findings in the temporal domain, showing that excess mortality was highest during the months
with a high number of vaccinations. The fact that particularly high excess mortality occurs both
in regions and in time windows in which many vaccinations took place provide strong correla-
tional evidence that the vaccinations may have had a negative effect instead of a positive effect.
These findings support recent concerns about the COVID-vaccinations (Mead et al. [22]), and
substantiate the suspicion that the negative side effects of the vaccination may possibly outweigh
the positive effects.
Acknowledgement
Part of this work was done during a stay of MR at the Trimester Program Synergies between
modern probability, geometric analysis and stochastic geometry at the Hausdorff Research Institute
for Mathematics (HIM) in Bonn (Germany).
References
[1] Australian Bureau of Statistics: Measuring Australia’s excess mortality during the
COVID-19 pandemic until the first quarter 2023. ABS, accessed 7 December 2023.
https://www.abs.gov.au/articles/measuring-australias-excess-mortality-during-covid-19-
pandemic-until-first-quarter-2023
[2] Barcel´o, M.A., Saez, M. Methodological limitations in studies assessing the effects of environ-
mental and socioeconomic variables on the spread of COVID-19: a systematic review. Environ
Sci Eur 33, 108 (2021). https://doi.org/10.1186/s12302-021-00550-7
[3] Bonacina F., Bo¨elle P., Colizza V., Lopez O., Thomas M., Poletto C.: Global patterns and
drivers of influenza decline during the COVID-19 pandemic. Int. J. Infectious Diseases 128,
132–139 (2023). https://doi.org/10.1016/j.ijid.2022.12.042
[4] De Nicola G., Kauermann G., ohle G.: On assessing excess mortality in Germany
during the COVID-19 pandemic (Zur Berechnung der ¨
Ubersterblichkeit in Deutschland
ahrend der COVID-19-Pandemie). AStA Wirtsch Sozialstat Arch 16, 5–20, (2022).
https://doi.org/10.1007/s11943-021-00297-w
[5] De Nicola G., Kauermann G.: An update on excess mortality in the second year of the
COVID-19 pandemic in Germany (Ein Update zur ¨
Ubersterblichkeit im zweiten Jahr der
COVID-19 Pandemie in Deutschland). AStA Wirtsch Sozialstat Arch 16, 21–24 (2022).
https://doi.org/10.1007/s11943-022-00303-9
22
[6] De Nicola G., Kauermann G.: Estimating excess mortality in high-
income countries during the COVID-19 pandemic. preprint (2023),
www.researchgate.net/publication/371164019 Estimating excess mortality in high-
income countries during the COVID-19 pandemic
[7] Deleveaux S., Clarke-Kregor A., Fonseca-Fuentes X., Mekhaiel E.: Exploring the Possible
Phenomenon of Viral Interference Between the Novel Coronavirus and Common Respiratory
Viruses. J Patient Cent Res Rev. 10(2), 91–97 (2023). https://dx.doi.org/10.17294/2330-
0698.1995
[8] Federal Statistical Office of Germany: Life tables. www-
genesis.destatis.de/genesis//online?operation=table&code=12621-0001 (Accessed on June 9,
2023)
[9] Federal Statistical Office of Germany: Population statistics. www-
genesis.destatis.de/genesis//online?operation=table&code=12411-0006 (Accessed on January
19, 2023)
[10] Federal Statistical Office of Germany: Death statistics.
www.destatis.de/DE/Themen/Gesellschaft-Umwelt/Bevoelkerung/Sterbefaelle-
Lebenserwartung/Tabellen/sonderauswertung-sterbefaelle.html (Accessed on February
16, 2023)
[11] Federal Statistical Office of Germany: Long-term Care
(Pflegestatistik). https://www.destatis.de/DE/Themen/Gesellschaft-
Umwelt/Gesundheit/Pflege/Publikationen/Downloads-Pflege/laender-pflegebeduerftige-
5224002219005.xlsx
[12] Federal Statistical Office of Germany: Number of live births.
https://www-genesis.destatis.de/genesis//online?operation=table&code=12612-
0100&bypass=true&levelindex=0&levelid=1706808828618 (Accessed on January 31, 2024).
[13] Federal Statistical Office of Germany: Number of stillbirths.
https://www-genesis.destatis.de/genesis//online?operation=table&code=12612-
0106&bypass=true&levelindex=0&levelid=1706808828618 (Accessed on January 31, 2024).
[14] Fraiman J, Erviti J, Jones M, Greenland S, Whelan P, Kaplan RM, Doshi P: Serious adverse
events of special interest following mRNA COVID-19 vaccination in randomized trials in
adults. Vaccine 40, 5798–5805 (2022) https://doi.org/10.1016/j.vaccine.2022.08.036
[15] German Association of Actuaries (DAV): Life table DAV 2004R. ht-
tps://aktuar.de/Dateien extern/DAV/LV/UT LV 7.pdf
[16] Grosman, S., Scott, I.A.: Quality of observational studies of clinical interven-
tions: a meta-epidemiological review. BMC Med Res Methodol 22, 313 (2022)
https://doi.org/10.1186/s12874-022-01797-1
[17] Health Care Datenplattform: Corona Severity Index (Maßnahmenindex Bundesl¨ander).
https://www.healthcare-datenplattform.de/dataset?tags=corona-massnahmen
[18] Jefferson T.: Influenza vaccination: policy versus evidence. BMJ 333: 912 (2006). ht-
tps://doi.org/10.1136/bmj.38995.531701.80
[19] Kuhbandner C, Homburg S, Walach H, Hockertz, S. Was Germany’s Lockdown in Spring 2020
Necessary? How Bad Data Quality Can Turn a Simulation Into a Delusion that Shapes the
Future. Futures 135: 102879 (2022) https://doi.org/10.1016/j.futures.2021.102879
23
[20] Kuhbandner C., Reitzner M.: Estimation of Excess Mortality in Germany During 2020-2022.
Cureus 15(5): e39371 (2023) https://dx.doi.org/doi:10.7759/cureus.39371
[21] Kye B.: Excess Mortality During the COVID-19 Pandemic in South Korea. Comparative
Population Studies 48 (2023) https://doi.org/10.12765/CPoS-2023-26
[22] Mead M.N., Seneff S., Wolfinger R., Rose J., Denhaerynck K., Kirsch S., McCullough P.A.:
COVID-19 mRNA Vaccines: Lessons Learned from the Registrational Trials and Global Vac-
cination Campaign. Cureus 16(1): e52876 (2024). https://doi.org/10.7759/cureus.52876
[23] Michels C., Perrier D., Kunadhasan J., et al.: Forensic Analysis of the 38 Subject Deaths
in the 6-Month Interim Report of the Pfizer/BioNTech BNT162b2 mRNA Vaccine Clinical
Trial. International Journal of Vaccine Theory, Practice, and Research 3(1), 973–1009 (2023).
https://doi.org/10.56098/ijvtpr.v3i1.85
[24] Reitzner M.: Longevity trend in Germany. Eur. Actuar. J., to appear (2024)
https://doi.org/10.1007/s13385-023-00369-x
[25] Robert Koch-Institut: Bericht zur Epidemiologie der Influenza in Deutschland, Saison
2017/18, Berlin 2018.
[26] oßler M., Schulte C., Hertle D., Repschl¨ager U., Wende D.: Analyse der ¨
Ubersterblich-
keit ahrend der COVID-19-Pandemie in Deutschland, 2020–2022. Barmer Reporte ht-
tps://www.bifg.de/publikationen/epaper/10.30433/ePGSF.2023.005
[27] Scherb H., Hayashi K.: Annual All-Cause Mortality Rate in Germany and Japan (2005 to
2022) With Focus on The Covid-19 Pandemic: Hypotheses And Trend Analyses. Med. Clin.
Sci. 5(2), 1–7 (2023) https://dx.doi.org/10.33425/2690-5191.1077
[28] Statistische ¨
Amter des Bundes und der ander: Gross Domestic Product (Bruttoin-
landsprodukt, Bruttowertsch¨opfung). https://www.statistikportal.de/de/vgrdl/ergebnisse-
laenderebene/bruttoinlandsprodukt-bruttowertschoepfung
[29] Statistische ¨
Amter des Bundes und der ander: At-risk-of-poverty Rate (Armutsgef¨ahrdung-
squote). https://www.statistikportal.de/de/sbe/ergebnisse/einkommen-armutsgefaehrdung-
und-soziale-lebensbedingungen/armutsgefaehrdung-und-4
[30] Talic S., Shah S., Wild H., Gasevic D., Maharaj A., Ademi Z. et al.: Effectiveness of
public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission,
and covid-19 mortality: systematic review and meta-analysis. BMJ 375: e068302 (2021)
https://doi.org/10.1136/bmj-2021-068302
[31] Thomas S., Moreira E.D., Kitchin N., et al.: Safety and Efficacy of the BNT162b2 mRNA
Covid-19 Vaccine through 6 Months. New England Journal of Medicine 385 (19), 1761–1773
(2021). https://doi.org/10.1056/NEJMoa2110345
[32] Thum M.: ¨
Ubersterblichkeit im zweiten Halbjahr 2021 in den deutschen Bundesl¨andern.
ifo Dresden berichtet 29 (2), 03–05. (2022) https://www.ifo.de/DocDL/ifoDD 22-02 03-
05 Thum.pdf
[33] von Stillfried S., ulow R. D., ohrig R., Boor P., for the German Registry of COVID-19
Autopsies (DeRegCOVID): First report from the German COVID-19 autopsy registry. The
Lancet Regional Health - Europe 15, 100330 (2022). doi.org/10.1016/j.lanepe.2022.100330
24
[34] Wu N., Joyal-Desmarais K., Ribeiro P., Vieira A. M., Stojanovic J., Sanuade C., et al.: Long-
term effectiveness of COVID-19 vaccines against infections, hospitalisations, and mortality
in adults: findings from a rapid living systematic evidence synthesis and meta-analysis up
to December, 2022 Lancet Respir. Med. 11, 439–452 (2023). https://doi.org/10.1016/S2213-
2600(23)00015-2
Statements and Declarations
Competing Interests: All authors have declared that no financial support was received from
any organization for the submitted work. All authors have declared that they have no financial
relationships at present or within the previous three years with any organizations that might have
an interest in the submitted work.
Christof Kuhbandner Matthias Reitzner
Universit¨at Regensburg Universit¨at Osnabr¨uck
Institut ur Experimentelle Psychologie Institut ur Mathematik
93040 Regensburg 49069 Osnabr¨uck
Germany Germany
25
6 Supplement: Correlations between excess mortality in the pan-
demic years and the monthly vaccination rates.
The supplementary Figure 7 shows the correlations between the excess mortality observed in a
federal state in the second and third pandemic year and the monthly rates of double and triple
vaccinated people.
Figure 7: The correlations between the excess mortality in the second (A) and third (B) pandemic
year and the monthly rates of double and triple vaccinated people are shown.
As can be seen, in the third pandemic year, the level of correlation is identical regardless on
which month or type of vaccination (second vaccinations, third vaccinations) the vaccination rate
of a federal state is based. In the second pandemic year, the same picture emerges as soon as the
vaccination rates have reached relevant levels.
26
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Background This meta-epidemiological study aimed to assess methodological quality of a sample of contemporary non-randomised clinical studies of clinical interventions. Methods This was a cross-sectional study of observational studies published between January 1, 2012 and December 31, 2018. Studies were identified in PubMed using search terms ‘association’, ‘observational,’ ‘non-randomised’ ‘comparative effectiveness’ within titles or abstracts. Each study was appraised against 35 quality criteria by two authors independently, with each criterion rated fully, partially or not satisfied. These quality criteria were grouped into 6 categories: justification for observational design (n = 2); minimisation of bias in study design and data collection (n = 11); use of appropriate methods to create comparable groups (n = 6); appropriate adjustment of observed effects (n = 5); validation of observed effects (n = 9); and authors interpretations (n = 2). Results Of 50 unique studies, 49 (98%) were published in two US general medical journals. No study fully satisfied all applicable criteria; the mean (+/−SD) proportion of applicable criteria fully satisfied across all studies was 72% (+/− 10%). The categories of quality criteria demonstrating the lowest proportions of fully satisfied criteria were measures used to adjust observed effects (criteria 20, 23, 24) and validate observed effects (criteria 25, 27, 33). Criteria associated with ≤50% of full satisfaction across studies, where applicable, comprised: imputation methods to account for missing data (50%); justification for not performing an RCT (42%); interaction analyses in identifying independent prognostic factors potentially influencing intervention effects (42%); use of statistical correction to minimise type 1 error in multiple outcome analyses (33%); clinically significant effect sizes (30%); residual bias analyses for unmeasured or unknown confounders (14%); and falsification tests for residual confounding (8%). The proportions of fully satisfied criteria did not change over time. Conclusions Recently published observational studies fail to fully satisfy more than one in four quality criteria. Criteria that were not or only partially satisfied were identified which serve as remediable targets for researchers and journal editors.
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At the peak of the 2021 wave of the SARS-CoV-2 alpha variant in North America, there was concern for a superimposed wave of viral respiratory infections. There was, however, an apparent shift in the usual epidemiology of these pathogens, especially during the traditional influenza season from approximately October 2020 to March 2021. This article seeks to briefly describe the epidemiology of notable respiratory pathogens during the first wave of the COVID-19 pandemic and to focus on one possible factor for the trends observed. There are many contributory elements to the observed viral trends, but in particular, we present a synopsis of the data supporting the phenomenon of viral interference in relation to the clinically relevant early variants of SARS-CoV-2 (ancestral lineage, alpha, delta, omicron). Viral interference has been implicated in previous pandemics and is currently not well characterized in the setting of the COVID-19 pandemic. It is important to understand this dynamic and its effect on the predominant variants of COVID-19 thus far so that we may appropriately consider its possible influence in patient pathology going forward.
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Background: Synthesising evidence on the long-term vaccine effectiveness of COVID-19 vaccines (BNT162b2 [Pfizer-BioNTech], mRNA-1273 [Moderna], ChAdOx1 nCoV-19 [AZD1222; Oxford-AstraZeneca], and Ad26.COV2.S [Janssen]) against infections, hospitalisations, and mortality is crucial to making evidence-based pandemic policy decisions. Methods: In this rapid living systematic evidence synthesis and meta-analysis, we searched EMBASE and the US National Institutes of Health's iSearch COVID-19 Portfolio, supplemented by manual searches of COVID-19-specific sources, until Dec 1, 2022, for studies that reported vaccine effectiveness immediately and at least 112 days after a primary vaccine series or at least 84 days after a booster dose. Single reviewers assessed titles, abstracts, and full-text articles, and extracted data, with a second reviewer verifying included studies. The primary outcomes were vaccine effectiveness against SARS-CoV-2 infections, hospitalisations, and mortality, which were assessed using three-level meta-analytic models. This study is registered with the National Collaborating Centre for Methods and Tools, review 473. Findings: We screened 16 696 records at the title and abstract level, appraised 832 (5·0%) full texts, and initially included 73 (0·4%) studies. Of these, we excluded five (7%) studies because of critical risk of bias, leaving 68 (93%) studies that were extracted for analysis. For infections caused by any SARS-CoV-2 strain, vaccine effectiveness for the primary series reduced from 83% (95% CI 80-86) at baseline (14-42 days) to 62% (53-69) by 112-139 days. Vaccine effectiveness at baseline was 92% (88-94) for hospitalisations and 91% (85-95) for mortality, and reduced to 79% (65-87) at 224-251 days for hospitalisations and 86% (73-93) at 168-195 days for mortality. Estimated vaccine effectiveness was lower for the omicron variant for infections, hospitalisations, and mortality at baseline compared with that of other variants, but subsequent reductions occurred at a similar rate across variants. For booster doses, which covered mostly omicron studies, vaccine effectiveness at baseline was 70% (56-80) against infections and 89% (82-93) against hospitalisations, and reduced to 43% (14-62) against infections and 71% (51-83) against hospitalisations at 112 days or later. Not enough studies were available to report on booster vaccine effectiveness against mortality. Interpretation: Our analyses indicate that vaccine effectiveness generally decreases over time against SARS-CoV-2 infections, hospitalisations, and mortality. The baseline vaccine effectiveness levels for the omicron variant were notably lower than for other variants. Therefore, other preventive measures (eg, face-mask wearing and physical distancing) might be necessary to manage the pandemic in the long term. Funding: Canadian Institutes of Health Research and the Public Health Agency of Canada.