Human performance optimization (HPO) represents a paradigm shift in training and maintenance that emphasizes enhancing human physiological and cognitive performance while also transitioning medical care from reactive to preventative. Fundamentally, the HPO model domains are interlaced together. This means all domains are working together no matter the status of the human weapon system (HWS) within the Healthcare Continuum. However, the success of any HPO initiative heavily relies on the acceptance by the HWS community, known as the buy-in. This chapter contends that the interlaced, domain-based approach encourages synergy between various domains. Examples of such integrative HPO programs, like the Force and Family (POTFF) and True North, highlight the potential benefits of this reimagined approach. Crucially, the domain-based HPO framework aligns more with preventative medicine, emphasizing proactive interventions to avoid injuries and illnesses, as opposed to the traditional reactive medical models. The HPO aims to sustainably maximize human potential through this holistic, domain-focused approach, fostering an improved quality of life and a shift toward proactive healthcare.