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Continence 7S1 (2023) ICS 2023 Toronto Abstracts
100 | www.ics.org/2023/abstract/100
EFFICACY OF INTRADETRUSOR PLATELET-
RICH PLASMA INJECTION IN TREATMENT OF
INTERSTITIAL CYSTITIS
Medvedev V1, Lepetunov S1, Manuilov V1, Kogan M2, Medvedev A1
1. Kuban State Medical University, Krasnodar, 2. Rostov State Medical
University, Rostov-on-Don.
HYPOTHESIS / AIMS OF STUDY
The therapy of moderate and severe symptoms of interstitial cystitis (IC)
recommended in the EU guidelines is not as eective. Intravesical admin-
istration of platelet-rich plasma (PRP) can improve the results of treatment
of interstitial cystitis.
STUDY DESIGN, MATERIALS AND METHODS
A single-center controlled randomized prospective trial that includes 85
women from 20 to 79 years old and with disease duration of 4.8±2.1 years.
They were divided into 2 groups: 1 – 35 patients were treated with total
of 5 procedures of cystoscopy with hydrodistension, each once in 2 weeks,
2 - 50 patients were treated with total of 5 intradetrusor PRP- injection into
20-22 points, each procedure was made once in 2 weeks (mean platelet con-
centration was 982х103/l). We assessed pain (VAS-scale), urgency and fre-
quency (PUF-scale, IUS-scale), bladder diary, Global Response Assessment
(GRA), bladder diary and bladder capacity before treatment, after 1 and 12
months. Statistical analysis was made with Statistica 11.0 Software
RESULTS
All measurements are presented in table 1:
Table 1. Evaluation of symptoms, bladder capacity and other signs before
and after treatment
S y m p t o m s a n d s i g n s B e f o r e t r e a t m e n t
After treatment
I group/II group I
group (n=35) II group (n=50)
1m 12m 1m 12m.
VAS-scale, score 7,3*/7,6**
3,7* 6,0* 3,3** 3,5**
Frequency, number 20*/21**
13,9* 16,0* 14,0** 12,2**
Daytime urination, number 16,8*/18**
10,5* 13,2* 11* 10*
N i g h t u r i n a t i o n , n u m b e r 3 , 2 * / 3 * *
3,4* 2,8* 3* 2,2**
Urgency, score 2,5*/2,6**
1,6* 2,0* 1,9** 1,6**
Bladder capacity, ml 201,7*/178,2**
302,3* 313,7* 332,0** 347,5**
PUF scale, total score 27,4*/24,6** 17,6*
22,9* 15,9** 13,7**
PUF scale, symptoms, score 18,1*/15,8** 11,1*
14,5* 11,9** 9,5**
PUF scale bothersomeness, score 9,3*/8,8**
6,5* 8,4* 6,3** 4,3**
GRA, score 0/0
3,5* 1,8* 4,3** 3,8**
Hunners lession, % 100/100
– 74,6 – 28,0
Notes:
* р<0,05 (Wilcoxon rank test)
** р<0,05 (Wilcoxon rank test)
INTERPRETATION OF RESULTS
PRP therapy has shown positive results of reducing the clinical picture in
comparison with standard therapy. The introduction of platelet-rich plasma
has a benecial eect on the bladder mucosa, reducing the risk of Hunner's
ulcers.
CONCLUDING MESSAGE
Standard therapy of IC leads to a signicant decrease in the manifestations
of the disease after 1 months. The same results have been demonstrated in
PRP-group. However, there was worsening of symptoms in the 1st group
after 12 months (but they don’t reach the initial values). On the other hand,
there were a stable pain symptoms by 12th month in the 2d group and
improvement of other signs and symptoms (p<0,05) compared to initial
values and 1 month after PRP – injection.
Funding government funding (aspirnantura) Clinical Trial Yes Public
Registry No RCT Yes Subjects Human Ethics Committee Ethics Committee
Rostov State Medical University Helsinki Yes Informed Consent Yes
Continence 7S1 (2023) 100818
doi: 10.1016/j.cont.2023.100818