... Others include protein, phosphatase and tensin homolog (PTEN), and KIT, affecting cell metabolism, survival, and proliferation, ARID1 and 2 (AT-rich interaction domain 1 and 2) affecting cell identity, TP53 (tumor suppressor gene affecting resistance to apoptosis), TERT affecting replicative lifespan, and cell cycle control gene CDKN2A. There are several other mutations affecting melanoma progression in cutaneous melanoma exposed to sun [1,2,4,6,10,11,18,30,36,37,74,76,77,82,126,127] from which desmoplastic melanoma differ not in mutational load but in genes affected [36,132]. Acral melanomas, having no direct association with sun exposure, although having mutations in BRAF, NRAS, NF1, and KIT, show a lighter and different mutational burden in comparison to low-CSD or high-CSD melanomas [6,10,31,32,79,[133][134][135][136]. ...