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Minimizing visceral organ ischemia time for open repair of thoracoabdominal aortic disease: Description of a new method

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Journal of Cardiac Surgery
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Minimizing ischemic injury during surgical repair of thoracoabdominal aortic aneurysms (TAAAs) is vital for preventing complications such as paraplegia and acute renal failure. In this report, we describe a new technique for TAAA open repair that aims to minimize visceral organ ischemia times. Unlike typical Crawford extent II TAAA open repair, which begins with aortic clamping and proceeds from the proximal to the distal anastomoses, our method reverses the anastomosis order and minimizes aortic clamping. Between January 2016 and December 2020, we used this approach in 29 patients undergoing TAAA repair. We present one of these cases, a 29‐year‐old patient with progressive aneurysmal dilatation of a DeBakey type III chronic aortic dissection that extended beyond the aortic bifurcation. Our technique reduced aortic cross‐clamping, left heart bypass, and internal organ and spinal cord ischemia times and appears to be safe and effective.
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Received: 2 August 2022
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Accepted: 24 September 2022
DOI: 10.1111/jocs.17105
OPERATIVE TECHNIQUE
Minimizing visceral organ ischemia time for open repair
of thoracoabdominal aortic disease: Description of a
new method
Andrey V. Marchenko MD |Pavel A. Myalyuk PhD |Alexey A. Petrishchev MD
Federal Center for Cardiovascular Surgery
named after SG Sukhanov, Perm, Russian
Federation
Correspondence
Andrey V. Marchenko, MD, Federal Center for
Cardiovascular Surgery, 35 Marshala Jukova
St., Perm 614013, Russian Federation.
Email: mammaria@mail.ru
Abstract
Minimizing ischemic injury during surgical repair of thoracoabdominal aortic aneurysms
(TAAAs) is vital for preventing complications such as paraplegia and acute renal failure. In
this report, we describe a new technique for TAAA open repair that aims to minimize
visceral organ ischemia times. Unlike typical Crawford extent II TAAA open repair, which
begins with aortic clamping and proceeds from the proximal to the distal anastomoses,
our method reverses the anastomosis order and minimizes aortic clamping.
Between January 2016 and December 2020, we used this approach in 29 patients
undergoing TAAA repair. We present one of these cases, a 29yearold patient with
progressive aneurysmal dilatation of a DeBakey type III chronic aortic dissection that
extended beyond the aortic bifurcation. Our technique reduced aortic cross
clamping, left heart bypass, and internal organ and spinal cord ischemia times and
appears to be safe and effective.
KEYWORDS
open aneurysm repair, surgical technique, thoracoabdominal aneurysm
1|INTRODUCTION
Minimizing ischemic injury during thoracoabdominal aortic aneurysm
(TAAA) repair is essential.
14
Here,wedescribeanewmethodofopen
TAAA repair developed and implemented at our center (Federal Center
for Cardiovascular Surgery, Perm, Russian Federation) that minimizes
visceral organ ischemia. Unlike typical Crawford extent II TAAA open
repair, which begins with aortic clamping and proceeds from the proximal
to the distal anastomoses, our method reverses the anastomosis order
and minimizes aortic clamping. We perform the distal anastomoses first,
without aortic crossclamping; we do not crossclamp the aorta until we
perform the proximal anastomosis to complete the repair (Table 1).
Between January 2016 and December 2020, we used this approach in
29 patients undergoing TAAA repair. We present our technique as
applied in one of these cases (Supporting Information: Video 1).
This report was approved by Institutional Review Board of Federal
Center for Cardiovascular Surgery (Protocol No. 12, dated February 7,
2016). The patient gave informed consent for publication of this report.
2|CASE REPORT
A29yearold patient with Marfan syndrome was admitted to our
center with progressive aneurysmal dilatation of a DeBakey type III
chronic aortic dissection that extended beyond the aortic bifurcation.
We have identified on computed tomography a proximal fenestration of
the descending thoracic aorta 5 mm distal to the left subclavian artery,
and a maximum aortic size of 73 mm at the isthmus, 54 mm at the level
of diaphragm, 46 mm at the level of infrarenal aorta (Figure 1).
Before initiating repair, we established cerebrospinal fluid
drainage to mitigate spinal cord ischemia. Thoracophrenolumbotomy
was used to establish surgical access along the fourth intercostal
space, and the entire thoracoabdominal aorta, including the visceral
and iliac arteries, was mobilized. A physicianmodified neograft
was prepared from multibranch and singular grafts (Figure 2).
Without using left heart bypass (LHB) or aortic crossclamping,
we then performed endtoside anastomoses of the bifurcated
portion of the neograft to the left and right common iliac arteries
J Card Surg. 2022;37:56665669.wileyonlinelibrary.com/journal/jocs5666
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© 2022 Wiley Periodicals LLC.
Article
Full-text available
Aim: The present study aimed to analyze early and late outcomes after open repair of chronic type B aortic dissection. Methods: We retrospectively reviewed our cases of open descending thoracic aortic aneurysm (DTAA) with chronic dissection from 1991-2013. Long-term survival and aortic reinterventions were analyzed and patient comorbidities were evaluated in order to determine the risk of adverse outcomes. Furthermore, the technique for “distal first approach” is described. Results: Between 1991 and 2013, 240 (40%) descending thoracic aortic repairs with associated chronic dissection were performed. Mean age is 59 years and 178 (74%) are men. The majority of patients (218, 91%) underwent repair using the adjunct of distal aortic perfusion with cerebral spinal fluid drainage. Early mortality was 8.3% (20/240). Permanent neurologic deficit occurred in 1.3% (3/240). Stroke occurred in 2.9% (7/240), and dialysis on discharge in 6% (12/240). 5-, 10-, 15-, and 20-year survival was 72%, 60%, 45%, and 39%, respectively. Freedom from reoperation on the operated segment was 97%, 94%, 94% and 94% at 5, 10, 15 and 20 years. Conclusions: Open repairs of chronic descending thoracic dissections can be performed with respectable morbidity and mortality. Risk of neurologic deficit remains low with use of adjuncts, and risk of reintervention on the involved aortic segment is also low. These results allow comparison with endovascular repair for chronic aortic dissection.
Article
Objective: Since the pioneering era of E. Stanley Crawford, our multimodal strategy for thoracoabdominal aortic aneurysm repair has evolved. We describe our approximately 3-decade single-practice experience regarding 3309 thoracoabdominal aortic aneurysm repairs and identify predictors of early death and other adverse postoperative outcomes. Methods: We analyzed retrospective (1986-2006) and prospective data (2006-2014) obtained from patients (2043 male; median age, 67 [59-73] years) who underwent 914 Crawford extent I, 1066 extent II, 660 extent III, and 669 extent IV thoracoabdominal aortic aneurysm repairs, of which 723 (21.8%) were urgent or emergency. Repairs were performed to treat degenerative aneurysm (64.2%) or aortic dissection (35.8%). The outcomes examined included operative death (ie, 30-day or in-hospital death) and permanent stroke, paraplegia, paraparesis, and renal failure necessitating dialysis, as well as adverse event, a composite of these outcomes. Results: There were 249 operative deaths (7.5%). Permanent paraplegia and paraparesis occurred after 97 (2.9%) and 81 (2.4%) repairs, respectively. Of 189 patients (5.7%) with permanent renal failure, 107 died in the hospital. Permanent stroke was relatively uncommon (n = 74; 2.2%). The rate of the composite adverse event (n = 478; 14.4%) was highest after extent II repair (n = 203; 19.0%) and lowest after extent IV repair (n = 67; 10.2%; P < .0001). Estimated postoperative survival was 83.5% ± 0.7% at 1 year, 63.6% ± 0.9% at 5 years, 36.8% ± 1.0% at 10 years, and 18.3% ± 0.9% at 15 years. Conclusions: Repairing thoracoabdominal aortic aneurysms poses substantial risks, particularly when the entire thoracoabdominal aorta (extent II) is replaced. Nonetheless, our data suggest that thoracoabdominal aortic aneurysm repair, when performed at an experienced center, can produce respectable outcomes.
Article
Open surgical repair of thoracoabdominal aortic aneurysms (TAAAs) enables the effective replacement of the diseased aortic segment and reliably prevents aneurysm rupture. However, these operations also carry substantial risk of perioperative morbidity and mortality, principally caused by the associated ischemic insult involving the spinal cord, kidneys, and other abdominal viscera. Here, we describe the early outcomes of a contemporary series of open TAAA repairs. We reviewed the outcomes of 823 open TAAA repairs performed between January 2005 and May 2012. Of these, 209 (25.4%) were Crawford extent I repairs, 264 (32.1%) were extent II, 157 (19.1%) were extent III, and 193 (23.5%) were extent IV. Aortic dissection was present in 350 (42.5%) cases, and aneurysm rupture was present in 37 (4.5%). Adjuncts used during the procedures included cerebrospinal fluid drainage in 639 (77.6%) cases, left heart bypass in 430 (52.2%), and cold renal perfusion in 674 (81.9%). The composite endpoint, adverse outcome-defined as operative death, renal failure that necessitated dialysis at discharge, stroke, or permanent paraplegia or paraparesis-occurred after 131 (15.9%) procedures. There were 69 (8.4%) operative deaths. Permanent paraplegia or paraparesis occurred after 42 (5.1%) cases, stroke occurred after 27 (3.3%), and renal failure necessitating permanent dialysis occurred after 45 (5.5%). Although open surgical repair of the thoracoabdominal aorta can be life-saving to patients at risk for fatal aneurysm rupture, these operations remain challenging and are associated with substantial risk of early death and major complications. Additional improvements are needed to further reduce the risks associated with TAAA repair, particularly as increasing numbers of patients with advanced age and multiple or severe comorbidities present for treatment.
Article
As endovascular approaches to thoracoabdominal aortic repairs continue to evolve, careful assessment of the safety and efficacy of these alternative approaches will require comparison with standard open surgical repair. The purpose of this report is to update our experience with conventional open repair of thoracoabdominal aortic aneurysms. Since 1986, 2286 patients have undergone open repair of thoracoabdominal aortic aneurysms on our service. Of these, 1662 patients (72.7%) had degenerative aneurysms without dissection, 78 (3.4%) had acute aortic dissection, and 546 (23.9%) had chronic dissection. There were 139 ruptured aneurysms (6.1%). Extensive repairs (ie, Crawford extents I and II) were performed in 1468 patients (64.2%). Segmental intercostal or lumbar arteries were reattached in 1401 patients (61.3%), left heart bypass was used in 909 (39.8%), and cerebrospinal fluid drainage was used in 615 (26.9%). The 30-day survival rate was 95.0% (2171 patients). Renal failure requiring hemodialysis occurred in 129 patients (5.6%), and paraplegia or paraparesis developed in 87 patients (3.8%). Patients who underwent replacement of the entire thoracoabdominal aorta (extent II) had the highest rates of death (6.0%), spinal cord deficit (6.3%), and renal failure (8.3%). Current management strategies enable patients to undergo conventional open thoracoabdominal aortic aneurysm repair with excellent early survival and acceptable morbidity.